Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein.

abstract：:Pregnancy in sheep is associated with changes in numbers of specific T-lymphocyte populations in the uterine endometrium. These changes probably contribute to evasion by the conceptus of maternal immunological rejection and indicate a possible role for T cells in placental growth, parturition and post-parturient uteri...

journal_title：Immunology

authors： Majewski AC,Tekin S,Hansen PJ

更新日期：2001-03-01 00:00:00

abstract：:Preparations of ECF-A derived from anaphylactic guinea-pig lung diffusates were subjected to a variety of enzymatic degradations. The enzymes employed had specificityonly for their appropiate subtstates. No effect was found following treatmentwith relatively high doses of trypsin, alpha-chymotrypsin, pronase, alkali...

journal_title：Immunology

authors： Bach MK,Jones DG,Kay AB

更新日期：1975-04-01 00:00:00

abstract：:Peripheral blood lymphocytes from patients with Hashimoto's thyroiditis have been cultured for 2--3 weeks in Marbrook flasks. During this period, readily detectable amounts of thyroglobulin and microsomal antibodies were synthesized by the cells and secreted into the culture medium. Gel filtration studies indicated th...

journal_title：Immunology

authors： McGregor A,McLachlan S,Clark F,Smith BR,Hall R

更新日期：1979-01-01 00:00:00

abstract：:Natural killer (NK) cells have a specialized function in peripheral organs, which is determined by the organ-specific niches. We have attempted to explore whether lung NK cells display a particular phenotype according to their function in the unique pulmonary environment in health or during respiratory infection in mi...

journal_title：Immunology

authors： Wang J,Li F,Zheng M,Sun R,Wei H,Tian Z

更新日期：2012-09-01 00:00:00

abstract：:Spleen lymphocytes from C4-deficient (C4D) and Albany strains of guinea-pigs, 1-7 days, 3-6 and 12-16 months old, genetically related to inbred strains 13 and 2 respectively, were analysed in terms of their expression of cell surface markers, allogenic and T- and B-cell mitogenic responses, and interleukin-1 (IL-1) an...

journal_title：Immunology

authors： Zhao J,Wicher V,Burger R,Schafer H,Wicher K

更新日期：1992-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells fr...

journal_title：Immunology

authors： Dorner M,Brandt S,Tinguely M,Zucol F,Bourquin JP,Zauner L,Berger C,Bernasconi M,Speck RF,Nadal D

更新日期：2009-12-01 00:00:00

abstract：:The ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to e...

journal_title：Immunology

authors： Woods GM,Qu M,Ragg SJ,Muller HK

更新日期：1996-05-01 00:00:00

abstract：:Chemokine-mediated signalling involves the activation of a Janus kinase (Jak) pathway. We have previously shown that Jak3 mediates CCR9 and CXCR4 signalling in response to CCL25 and CXCL12 in BM progenitors and thymocytes. The lack of peripheral lymph nodes and Peyer's patches observed in Jak3(-/-) mice suggested a po...

journal_title：Immunology

authors： García-Zepeda EA,Licona-Limón I,Jiménez-Sólomon MF,Soldevila G

更新日期：2007-10-01 00:00:00

abstract：:The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus ...

journal_title：Immunology

authors： Ishikawa N,Horii Y,Oinuma T,Suganuma T,Nawa Y

更新日期：1994-03-01 00:00:00

abstract：:The immunosuppressive effect of cyclosporin A (CS-A) was investigated in RIC-Sprague-Dawley rats. In vivo, CS-A totally abolished the formation of antibodies to the hapten dinitrophenyl (DNP) in rats immunized with DNP-keyhole limpet haemocyanin. In vitro, the effect of CS-A was investigated in spleen cell cultures st...

journal_title：Immunology

authors： Burckhardt JJ,Guggenheim B

更新日期：1979-04-01 00:00:00

abstract：:The investigation of the role of the macrophage in cutaneous leishmaniasis has been prompted by observations of the clinical behaviour of the infection. In contrast to the self-healing oriental sore, chronic leishmaniasis is characterized by persistent lesions and leishmania recidiva by lesions that flare up locally l...

journal_title：Immunology

authors： Farah FS,Samra SA,Nuwayri-Salti N

更新日期：1975-10-01 00:00:00

abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...

journal_title：Immunology

authors： Miyata H,Himeno K,Miake S,Nomoto K

更新日期：1981-10-01 00:00:00

abstract：:Induction of expression of adhesion molecules is a crucial step in inflammation. The role of interleukin-18 (IL-18) in induction of various adhesion molecules was investigated in freshly isolated peripheral blood mononuclear cells and human monocyte and T-cell lines. IL-18 selectively up-regulated intercellular adhesi...

journal_title：Immunology

authors： Stuyt RJ,Netea MG,Geijtenbeek TB,Kullberg BJ,Dinarello CA,van der Meer JW

更新日期：2003-11-01 00:00:00

abstract：:Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...

journal_title：Immunology

authors： Acosta-Ramírez E,Pérez-Flores R,Majeau N,Pastelin-Palacios R,Gil-Cruz C,Ramírez-Saldaña M,Manjarrez-Orduño N,Cervantes-Barragán L,Santos-Argumedo L,Flores-Romo L,Becker I,Isibasi A,Leclerc D,López-Macías C

更新日期：2008-06-01 00:00:00

abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...

journal_title：Immunology

authors： Polson RJ,Jenkins R,Lombard M,Williams AC,Roberts S,Nouri-Aria K,Williams R,Bomford A

更新日期：1990-10-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...

journal_title：Immunology

authors： Gregory CD,Devitt A

更新日期：2004-09-01 00:00:00

abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...

journal_title：Immunology

authors： Mousavi M,Rabbani H,Hammarström L

更新日期：1997-11-01 00:00:00

abstract：:Pre-exposure to bacterial lipopolysaccharide (LPS) or certain cytokines is known to enhance the ability of murine macrophages to generate a respiratory burst in response to subsequent stimulation, a phenomenon referred to as 'priming'. We report here that the cytokine interleukin-4 (IL-4) can prime murine macrophages....

journal_title：Immunology

authors： Phillips WA,Croatto M,Hamilton JA

更新日期：1990-08-01 00:00:00

abstract：:The humoral and mucosal immune responses to oral immunization with xenogeneic antibodies were studied using an animal model in which female rabbits were fed daily doses of the MOPC-315 murine IgA antibody, and were mated during the course of the feeding programme. Serum and colostrum samples were assayed for the prese...

journal_title：Immunology

authors： Collins AM,Roberton DM,Hosking CS,Flannery GR

更新日期：1991-08-01 00:00:00

abstract：:Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) catalyse the formation of hypochlorite (OCl-) from chloride ions (OCl-) and hydrogen peroxide (H2O2). OCl- proved to be highly toxic for Trichinella spiralis newborn larvae (NBL) in in vitro assays. Using purified human MPO and EPO it was found that even at neutral...

journal_title：Immunology

authors： Buys J,Wever R,Ruitenberg EJ

更新日期：1984-03-01 00:00:00

abstract：:Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates the management of this pathological condition. An animal model of AD-like pruritus would contribute to a better understanding of AD and could lead to the development of safe and effective antipruritic agents. DS non-hair (DS-Nh) mi...

journal_title：Immunology

authors： Yoshioka T,Hikita I,Asakawa M,Hirasawa T,Deguchi M,Matsutani T,Oku H,Horikawa T,Arimura A

更新日期：2006-07-01 00:00:00

abstract：:Metabolism of ss-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; similar to effects produced in Swiss Webster mice that have been pretreated with a small dose of carbon b...

journal_title：Immunology

authors： Chia D,Dorsch C,Barnett EV,Levy L

更新日期：1977-03-01 00:00:00

abstract：:The chemokine receptor CCR7 is crucial for migration of mature dendritic cells (DC) directed toward secondary lymphoid organs; however, there is little knowledge about the function of the homeostatic chemokine receptor CXCR4 in DC and its contribution to directional migration of DC during inflammation. By comparing th...

journal_title：Immunology

authors： Humrich JY,Humrich JH,Averbeck M,Thumann P,Termeer C,Kämpgen E,Schuler G,Jenne L

更新日期：2006-02-01 00:00:00

abstract：:Mice injected intravenously with a high dose (5 X 10(7) ) of BCG fail to develop delayed hypersensitivity to BCG and are described as anergic or unresponsive. Spleen cells from these mice release factors on culture which suppress DNA synthesis induced by concanavalin A in vitro. Cell separation experiments showed that...

journal_title：Immunology

authors： Colizzi V,Ferluga J,Garreau F,Malkovsky M,Asherson GL

更新日期：1984-01-01 00:00:00

abstract：:The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phy...

journal_title：Immunology

authors： Kicza K,Fischer A,Pfeil T,Bujanowski-Weber J,König W

更新日期：1989-12-01 00:00:00

abstract：:The role of Foxp3(+) regulatory T (Treg) cells in the course of the early hyper-inflammatory and subsequent hypo-inflammatory phases of sepsis is ambiguous. Whereas Nrp1 expression has been reported to discriminate natural Treg cells from induced Treg cells, the Treg cell stability depends on the methylation status of...

journal_title：Immunology

authors： Tatura R,Zeschnigk M,Hansen W,Steinmann J,Vidigal PG,Hutzler M,Pastille E,Westendorf AM,Buer J,Kehrmann J

更新日期：2015-09-01 00:00:00

abstract：:In addition to macromolecular interactions that provide co-stimulation during antigen-presenting cell (APC) and CD4+ T-cell conjugation, covalent chemical events between specialized ligands have been implicated in T-cell co-stimulation. These take the form of transient Schiff base formation between carbonyls and amine...

journal_title：Immunology

authors： Hall SR,Rhodes J

更新日期：2001-09-01 00:00:00

abstract：:Bovine Concanavalin A-induced suppressor cells were generated from lymphocytes which were non-adherent to anti-immunoglobulin coated dishes and cells possessing receptors for peanut agglutinin. Bovine lymphocytes, preincubated with 25 microgram/ml of Con A for 40-45 hr, could suppress the responses of autologous cells...

journal_title：Immunology

authors： Smith WG,Usinger WR,Splitter GA

更新日期：1981-05-01 00:00:00

abstract：:In the study described here, the effect of human tears and purified lactoferrin was investigated on the deposition of complement components on solid-phase bound immune complexes. After incubating immune complexes with fresh normal human serum, the deposition of complement components (C3, C4 and C5) was measured with a...

journal_title：Immunology

authors： Kievits F,Kijlstra A

更新日期：1985-03-01 00:00:00