Abstract：
:Peripheral blood lymphocytes from patients with Hashimoto's thyroiditis have been cultured for 2--3 weeks in Marbrook flasks. During this period, readily detectable amounts of thyroglobulin and microsomal antibodies were synthesized by the cells and secreted into the culture medium. Gel filtration studies indicated that the autoantibodies produced in culture were of a similar molceular weight to the serum antibodies and this provided evidence that autoantibody synthesis in vitro was representative of autoantibody synthesis in vivo. Our data suggest that this culture technique may be used to make a detailed investigation of the human autoimmune disease process.
journal_name
Immunologyjournal_title
Immunologyauthors
McGregor A,McLachlan S,Clark F,Smith BR,Hall Rsubject
Has Abstractpub_date
1979-01-01 00:00:00pages
81-5issue
1eissn
0019-2805issn
1365-2567journal_volume
36pub_type
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