Abstract：
:Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to occur. The other, proposed more recently, has not yet gained general acceptance because the same effect can be produced by polymerase chain reaction artefact. We review both types of replacement including a critical examination of evidence for the latter. The first type involves RAG proteins and recombination signal sequences (RSS) and occurs in immature B cells. The second was also thought to be brought about by RAG proteins and RSS. However, it has been reported in hypermutating cells which are not thought to express RAG proteins but in which activation-induced cytidine deaminase (AID) has recently been shown to initiate homologous recombination. Re-examination of the published sequences reveals AID target sites in V(H)-V(H) junction regions and examples that resemble gene conversion.
journal_name
Immunologyjournal_title
Immunologyauthors
Darlow JM,Stott DIdoi
10.1111/j.1365-2567.2004.02084.xkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
155-65issue
2eissn
0019-2805issn
1365-2567pii
IMM2084journal_volume
114pub_type
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