Abstract：
:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are directed against neoepitopes on the C9 molecule, as assessed by binding and blocking experiments and studies with several forms of denatured C9 and C9-depleted serum. Only one of these mAb binds to soluble polymerized C9. All three mAb allow the quantification of human TCC in sensitive ELISA procedures and could be used as markers for the evaluation of the functions of non-lytic TCC on dendritic cells.
journal_name
Immunologyjournal_title
Immunologyauthors
Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze Osubject
Has Abstractpub_date
1991-09-01 00:00:00pages
132-8issue
1eissn
0019-2805issn
1365-2567journal_volume
74pub_type
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