Abstract：
:Haptoglobin (Hp), a major acute-phase plasma protein, has been found in arthritic synovial fluid (SF). However, the function and structural modifications of Hp in arthritic SF are unknown. To investigate in vivo generation of modified Hp associated with inflammatory disease, we examined a new Hp isoform in SF from patients with rheumatoid arthritis (RA). Specific Hp fragments of 28 000 and 15 000 molecular weight were identified in SF of patients with RA, and the two polypeptides were presumed to be fragments of the Hp β-chain (43 000 MW) produced by cleavage with plasmin. The 15 000 MW fragment, which is a C-terminal region of Hp, was observed at higher frequency and levels in RA than in osteoarthritis. Plasmin activity was also higher in SF of RA patients. A recombinant 15 000 MW Hp fragment up-regulated interlukin-6 expression in monocytic cells. These findings indicate that the C-terminal Hp fragment is generated by plasmin in local inflammatory environments and acts as an inflammatory mediator. They further suggest that a specific Hp fragment might be applied as a novel biomarker for the diagnosis and prognosis of inflammatory diseases such as RA.
journal_name
Immunologyjournal_title
Immunologyauthors
Park HJ,Oh MK,Kim NH,Cho ML,Kim ISdoi
10.1111/imm.12125subject
Has Abstractpub_date
2013-09-01 00:00:00pages
133-41issue
1eissn
0019-2805issn
1365-2567journal_volume
140pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01448.x
更新日期：2002-07-01 00:00:00
abstract：:In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8. Over a wide dose...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:We undertook a search for cytokine-inducible molecules present on brain endothelium and which are involved in the control of lymphocyte adhesion. We screened 39 monoclonal antibodies (mAb) against rat brain endothelium in vitro, and identified five recognizing cytokine-inducible molecules. None of the 39 antibodies bl...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:In addition to macromolecular interactions that provide co-stimulation during antigen-presenting cell (APC) and CD4+ T-cell conjugation, covalent chemical events between specialized ligands have been implicated in T-cell co-stimulation. These take the form of transient Schiff base formation between carbonyls and amine...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01290.x
更新日期：2001-09-01 00:00:00
abstract：:Self-reactive clones, estimated by anti-V beta monoclonal antibodies (mAb) in conjunction with the Mls system, are confined to a population of intermediate (int) T-cell receptor (TCR) (or CD3) cells (i.e. TCRint cells), but are not found among TCRhigh cells. The next questions to be answered are whether autologous kil...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00240.x
更新日期：1997-06-01 00:00:00
abstract：:Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 and M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal macrophages reduced the severity of experimental colitis in mice. However, it is still unclear whether peritoneal macrop...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12647
更新日期：2016-11-01 00:00:00
abstract：:The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phy...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Lymphocyte activation requires signal transduction mediated by reversible phosphorylation. Changing profiles of phosphorylated intermediates relate to the progressive series of transduction pathways in cells moving from G0 to G1, and thereafter through the cell cycle. We have previously shown that transient inhibition...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:During attempts to generate Sendai virus-specific T-cell hybridomas, a number of autoreactive T-cell hybridomas were produced. These hybrids secrete IL-2 in response to class II-positive syngeneic cells in the absence of added Sendai virus. Class II molecules on the stimulator cells are involved since monoclonal anti-...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12068
更新日期：2013-06-01 00:00:00
abstract：:In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic chemical, has been established as a diffusible universal messenger that mediates cell-cell communication throughout the body. Constitutive and inducible NO production regulate numerous essential functions of the gastrointestinal ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01984.x
更新日期：2004-12-01 00:00:00
abstract：:The role of the monocyte in human cytomegalovirus (HCMV)-induced immunosuppression was examined by assessing the ability of the virus to directly suppress various monocyte accessory cell functions. Both patient-derived and laboratory-adapted strains of HCMV were capable of impairing antigen-presenting functions of pur...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:The cytokine interleukin-12 (IL-12) is essential for resistance to Trypanosoma cruzi infection because it stimulates the synthesis of interferon-gamma (IFN-gamma), a major activator of the parasiticidal effect of macrophages. A less studied property of IL-12 is its ability to amplify the proliferation of T or natural ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01311.x
更新日期：2001-11-01 00:00:00
abstract：:Conjugates carrying a single 2-carboxy-4,6-dinitrophenyl hapten and as auxiliary group various thiazolidine substituents related to penicilloyl, were prepared and studied in guinea-pig passive cutaneous anaphylaxis (PCA). Included are monohaptenic model conjugates with discrete hydrocarbon auxiliary groups. One of the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:A suspension of nucleated femoral (BALB/c x CBA) bone marrow cells was inoculated, either into glass flasks or into flasks coated with a preformed syngeneic marrow derived monolayer, and cultured for long periods in media supplemented with hydrocortisone sodium succinate. Long term analysis of the lymphoid status of t...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The linker protein LAT is expressed mainly in T and natural killer (NK) cells. LAT-deficient mice have an arrest of intrathymic T-cell development at the CD4+ CD8+ stage and lack mature T cells in the periphery. However, no gross abnormality in development and function of the B and NK cells has been described. Here we...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01671.x
更新日期：2003-07-01 00:00:00
abstract：:Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12492
更新日期：2015-09-01 00:00:00
abstract：:In lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, alveolar macrophages (AMphi) produce much more tumour necrosis factor-alpha than peritoneal macrophages (PMphi) when stimulated with LPS (10 microgram/ml), but the induction of inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00908.x
更新日期：1999-12-01 00:00:00
abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03062.x
更新日期：2009-09-01 00:00:00
abstract：:Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02109.x
更新日期：2005-03-01 00:00:00
abstract：:In order to study the precise localization pattern of anti-TNP antibody-forming cells (AFCs) during the early primary immune response against TNP conjugated TD (thymus-dependent) and TI-2 (thymus-independent type-2) antigens, rats received an intravenous injection with either TNP-keyhole limpet haemocyanin (KLH) or wi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Treatment of b4b6 rabbit peripheral blood lymphocytes with b5b5 anti-b4 antibodies at 4 degrees resulted in the modulation (disappearance) ob b4 and b6 cell surface allotype after subsequent incubation in serum-free medium for 1 h at 37 degrees. A clear dose dependence on the sensitizing anti-b4 antibody was observed....
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:When normal human spleen cells are pulsed with concanavalin A (Con A), a portion become suppressor cells which in co-culture can inhibit immunoglobulin synthesis by other normal spleen cells stimulated by pokeweed mitogen (PWM). One mechanism whereby these Con-A activated spleen cells suppress Ig synthesis appears to ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Various strains of anaerobic coryneforms and the closely related Propionibacteria have been compared in vivo with respect to their anti-tumour activity. Their effectiveness has been correlated with their serological relationship and to some extent with their ability to stimulate the lymphoreticular system. Organisms b...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The negative role exerted by cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the regulation of T-cell activity, as induced by T-cell receptor (TCR)/CD3 and CD28 costimulation, has been widely described. In the present work we investigated the role of CTLA-4 in the control of cell activation, as induced by cost...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01493.x
更新日期：2002-10-01 00:00:00
abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing. In recent studies of experimental colitis we demonstrated exacerbated tissue destruction in OPN-null mice, associated with reduced tumour necrosis factor-alpha expression and increased mye...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02682.x
更新日期：2007-12-01 00:00:00
abstract：:N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01686.x
更新日期：2003-08-01 00:00:00
