Fetal calf serum stimulates 'autoreactive' T-cell hybridomas.

abstract：:Spleen cells from LAF1 mice primed with photo-oxidized antigen B exhibit helper T-cell activity when assayed in an adoptive transfer system with spleen cells from mice primed with timothy pollen extract and treated with anti-thy 1.2 serum and complement. These helper cells, when placed in culture with antigen B, secre...

journal_title：Immunology

authors： Brandt CJ,Deppe LB,Malley A

更新日期：1981-10-01 00:00:00

abstract：:Following exposure of mice to contact sensitizing chemicals, dendritic cells (DC) rapidly accumulate in the draining lymph nodes. A proportion, at least, of the DC which arrive in the nodes bear significant amounts of antigen and are derived from epidermal Langerhans' cells (LC). It is of interest that although LC are...

journal_title：Immunology

authors： Cumberbatch M,Gould SJ,Peters SW,Kimber I

更新日期：1991-11-01 00:00:00

abstract：:The major site of B-cell genesis in the sheep is the ileal Peyer's patch (PP). The B cells in the ileal PP undergo both extensive proliferation and massive death in association with an ongoing diversification of the immunoglobulin repertoire by somatic hypermutation. Most, if not all, the B-cell death in the ileal PP ...

journal_title：Immunology

authors： Motyka B,Reynolds JD

更新日期：1995-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...

journal_title：Immunology

authors： Webb LM,Foxwell BM,Feldmann M

更新日期：1999-11-01 00:00:00

abstract：:Rabbits immunized with complexes of denatured calf thymus DNA and methylated bovine serum albumin (MBSA) produced only IgM antibodies to denatured DNA, confirming the results of previous studies. In contrast, both IgM and IgG antibodies were induced by MBSA complexes of Trypanosoma brucei DNA. A similar response was o...

journal_title：Immunology

authors： Kushimo JB

更新日期：1976-05-01 00:00:00

abstract：:Chlamydiae are a major cause of infertility and preventable blindness and there is currently no effective vaccine in humans or rodents against these organisms. We have previously shown that a peptide of 12 amino acids (termed TINKP) from a conserved region of the major outer membrane protein (MOMP) of Chlamydia tracho...

journal_title：Immunology

authors： Knight SC,Iqball S,Woods C,Stagg A,Ward ME,Tuffrey M

更新日期：1995-05-01 00:00:00

abstract：:We previously identified a cis-acting element within the 3' untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequences of the three binding sites with re...

journal_title：Immunology

authors： Laughlin J,Oghlidos S,Porter JF,Matus-Nicodemos R,Sinquett FL,Marcelli V,Covey LR

更新日期：2008-07-01 00:00:00

abstract：:Regulatory T (Treg) cells act to suppress activation of the immune system and thereby maintain immunological homeostasis and tolerance to self-antigens. The frequency and suppressing activity of Treg cells in general are high in different malignancies. We wanted to identify the role and regulation of CD4(+)  CD25(+)  ...

journal_title：Immunology

authors： Bhattacharya K,Chandra S,Mandal C

更新日期：2014-05-01 00:00:00

abstract：:We have analysed the heavy and light chain variable region genes of two monoclonal antibodies, specific for the Sm antigen (RSP1; IgG kappa) and for cardiolipin (RSP4; IgM lambda), derived from a patient with active systemic lupus erythematosus (SLE). We have established that the variable region genes of the RSP1 auto...

journal_title：Immunology

authors： Demaison C,Ravirajan CT,Isenberg DA,Zouali M

更新日期：1995-11-01 00:00:00

abstract：:The immunizing ability of immune complexes preformed between EA and EA-hyperimmune serum was investigated in adult rats. After immunization with complexes at equivalence, the pattern of suppressed IgE responsiveness was similar to that induced when a small volume of immune serum accompanied routine immunization. We ha...

journal_title：Immunology

authors： Hall EP,Gault EA

更新日期：1987-08-01 00:00:00

abstract：:Stimulated T lymphocytes and certain T-cell hybridomas secrete molecules capable of inducing B-lymphocyte proliferation and differentiation. It has been shown recently that one such B-cell stimulatory factor is associated with chondroitin sulphate proteoglycan (CSPG) and was designated T-cell proteoglycan fraction, or...

journal_title：Immunology

authors： Levitt D

更新日期：1988-08-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Monoclonal antibodies (MAb) against sequential or conformational epitopes on foot-and-mouth disease virus (FMDV) passively protected neonatal syngeneic (BALB/c) mice at dilutions at which they could not neutralize virus infectivity in vitro. The B2, D9, 1C6 and 4C9 MAb, against the Group 1 (sequential) and Group 2 (co...

journal_title：Immunology

authors： McCullough KC,Crowther JR,Butcher RN,Carpenter WC,Brocchi E,Capucci L,De Simone F

更新日期：1986-07-01 00:00:00

abstract：:Crry (CR1-related gene/protein) is a rodent complement regulator that inhibits C3 convertases. CD59 is a conserved protein inhibitor active towards C8 and C9. We have previously produced rat Crry as a recombinant soluble (rs) protein in Pichia pastoris. In this study we produced functionally active rat rsCD59 and a ch...

journal_title：Immunology

authors： Quigg RJ,He C,Hack BK,Alexander JJ,Morgan BP

更新日期：2000-01-01 00:00:00

abstract：:It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...

journal_title：Immunology

authors： Yoshikai Y,Matsuzaki G,Inoue T,Nomoto K

更新日期：1990-05-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Two phenotypically distinct subpopulations of dendritic cells (SIRPalpha+ CC81Ag- DC and SIRPalpha- CC81Ag+ DC) have previously been identified in bovine afferent lymph which show functional differences when assayed in vitro. The purpose of this study was to investigate whether differences in cytokine production betwe...

journal_title：Immunology

authors： Stephens SA,Brownlie J,Charleston B,Howard CJ

更新日期：2003-09-01 00:00:00

abstract：:Peritoneal macrophages from CBA mice incubated with recombinant murine tumour necrosis factor (TNF-alpha) are effective in killing the protozoa parasite Leishmania major in vitro. The leishmanicidal activity is directly correlated with the level of nitrite (NO2-) in the culture supernatants. The killing of intracellul...

journal_title：Immunology

authors： Liew FY,Li Y,Millott S

更新日期：1990-12-01 00:00:00

abstract：:Polyclonal rabbit anti-idiotypic (Ab2) antibodies raised against the antiprogesterone mAb DB3 (Ab1) were used to induce an Ab3 antiprogesterone response in BALB/c mice. While the affinity of Ab3 sera for progesterone was 10-50-times lower than that of DB3, their steroid-binding specificity showed considerable similari...

journal_title：Immunology

authors： Kirsch RD,Beale D,He M,Corper AL,Krawinkel-Brenig U,Taussig MJ

更新日期：2000-06-01 00:00:00

abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...

journal_title：Immunology

authors： Gerber SA,Sorensen EW,Sedlacek AL,Lim JY,Skrombolas D,Frelinger JG,Lord EM

更新日期：2013-03-01 00:00:00

abstract：:The locomotor capacity of human lymphocytes is cell cycle-related. Many small blood lymphocytes are non-motile but acquire locomotor capacity in G1 on appropriate activation with e.g. anti-CD3 antibody (aCD3) for T cells, or interleukin-4 (IL-4) for B cells. Once this capacity is acquired, the cells can then respond b...

journal_title：Immunology

authors： Wilkinson PC,Watson EA

更新日期：1990-11-01 00:00:00

abstract：:Binding of streptococcal antigen was compared between T8+ cells and monocytes (Mo) from DRw6+ and DRw6- subjects. Both T8+ cells and Mo from DRw6- subjects bind streptococcal antigen (SA) specifically and almost entirely at a concentration of 1000 ng per 0.1 ml. However, the DRw6+, T8+ cells bind SA at a concentration...

journal_title：Immunology

authors： Lehner T,Jones T

更新日期：1984-10-01 00:00:00

abstract：:Monocyte-derived macrophages (MDMs) generated from peripheral blood monocytes are widely used to model human macrophages for in vitro studies. However, the possible impact of different isolation methods on the resulting MDM phenotype is poorly described. We aimed to investigate the effects of three commonly used monoc...

journal_title：Immunology

authors： Nielsen MC,Andersen MN,Møller HJ

更新日期：2020-01-01 00:00:00

abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

journal_title：Immunology

authors： Sivakumar PV,Foster DC,Clegg CH

更新日期：2004-06-01 00:00:00

abstract：:The specific recognition of the acetylcholine receptor and its alpha-subunit by T cells derived from patients with myasthenia gravis or mice with experimental autoimmune myasthenia gravis raises the question of the role of autoreactive T cells in the myasthenic process. Sequences of the acetylcholine receptor alpha-su...

journal_title：Immunology

authors： Brocke S,Dayan M,Rothbard J,Fuchs S,Mozes E

更新日期：1990-04-01 00:00:00

abstract：:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed ...

journal_title：Immunology

authors： Hübner MP,Stocker JT,Mitre E

更新日期：2009-08-01 00:00:00

abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...

journal_title：Immunology

authors： Casellas R,Yamane A,Kovalchuk AL,Potter M

更新日期：2009-03-01 00:00:00

abstract：:Donor T cells are crucial for target organ injury in graft-versus-host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent-into-F1 model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical...

journal_title：Immunology

authors： Kataoka Y,Iwasaki T,Kuroiwa T,Seto Y,Iwata N,Hashimoto N,Ogata A,Hamano T,Kakishita E

更新日期：2001-07-01 00:00:00

abstract：:Acquisition of T-cell central tolerance involves distinct pathways of self-antigen presentation to thymocytes. One pathway termed indirect presentation requires a self-antigen transfer step from thymic epithelial cells (TECs) to bone marrow-derived cells before the self-antigen is presented to thymocytes. The role of ...

journal_title：Immunology

authors： Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR

更新日期：2018-07-01 00:00:00