Differences in cytokine synthesis by the sub-populations of dendritic cells from afferent lymph.

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:Although interleukin-21 (IL-21) potently activates and controls the differentiation of immune cells after stimulation in vitro, the role for this pleiotropic cytokine during in vivo infection remains poorly defined. Herein, the requirement for IL-21 in innate and adaptive host defence after Listeria monocytogenes infe...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Rowe JH,Way SS

更新日期：2010-10-01 00:00:00

abstract：:Accumulating evidence indicates that B cells may undergo sequential rearrangements at the light chain loci, despite already expressing light chain receptors. This phenomenon may occur in the bone marrow and, perhaps, in germinal centers. As immunoglobulin (Ig)kappa light chains usually rearrange before Iglambda light ...

journal_title：Immunology

authors： Perfetti V,Vignarelli MC,Palladini G,Navazza V,Giachino C,Merlini G

更新日期：2004-07-01 00:00:00

abstract：:The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...

journal_title：Immunology

authors： Kikuchi T,Uehara S,Ariga H,Tokunaga T,Kariyone A,Tamura T,Takatsu K

更新日期：2006-01-01 00:00:00

abstract：:The subcutaneous (s.c.) injection of sheep red blood cells (SRBC) without adjuvant into mice preferentially induced delayed hypersensitivity (DH) reaction, as measured by footpad swelling, while intraperitoneal (i.p.) measured by the haemagglutinin test. Under these conditions, the properties of the helper activities...

journal_title：Immunology

authors： Tamura SI,Egashira Y

更新日期：1975-05-01 00:00:00

abstract：:The experiments described in this paper have examined the migration of three fluorochrome-labelled T-lymphocyte subsets (CD4+, CD8+ and gamma delta+T19+) on a single passage from blood to lymph, through prescapular lymph nodes. Lymphocytes obtained from prescapular efferent lymph were labelled in vitro with fluorochro...

journal_title：Immunology

authors： Witherden DA,Kimpton WG,Washington EA,Cahill RN

更新日期：1990-06-01 00:00:00

abstract：:The effects of a single dose of cyclophosphamide (ranging from 12 x 5 mg/m2 to 500 mg/m2) on rat spleens have been studied using quantitative morphometric techniques. The results obtained show that a single dose of cyclophosphamide (500 mg/m2) caused the destruction of primary and secondary follicles and less extensiv...

journal_title：Immunology

authors： Kumararatne DS,Gagnon RF,Smart Y

更新日期：1980-05-01 00:00:00

abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...

journal_title：Immunology

authors： Miyata H,Himeno K,Miake S,Nomoto K

更新日期：1981-10-01 00:00:00

abstract：:Lymphocyte migration into inflammatory sites involves a change from a spherical, non-motile phenotype to an irregular, constantly shape-changing, motile phenotype. We have previously shown that lymphocytes are maintained in the non-motile state by the constitutive activity of protein kinase C (PKC). In this paper we h...

journal_title：Immunology

authors： Thorp KM,Verschueren H,De Baetselier P,Southern C,Matthews N

更新日期：1996-03-01 00:00:00

abstract：:Mice homozygous for the gld (generalized lymphoproliferative disease) and lpr (lymphoproliferation) mutations display similar autoimmune and lymphoproliferative diseases. Both result from defective apoptosis, the targets of the lpr and gld mutations being the genes for, respectively, an apoptosis-signalling receptor [...

journal_title：Immunology

authors： Rosenblatt N,Hartmann KU,Loor F

更新日期：1995-04-01 00:00:00

abstract：:Mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP3K family. Recently, we found that MEKK3 plays a critical role in interleukin-1 (IL-1) receptor and Toll-like receptor 4 signalling using established primary mouse embryonic fibroblast (MEF)...

journal_title：Immunology

authors： Kim K,Duramad O,Qin XF,Su B

更新日期：2007-02-01 00:00:00

abstract：:Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...

journal_title：Immunology

authors： Carter J,Magnuson NS,Davis WC,Mason PH,Magnuson JA,Talmadge JE,Barr PJ

更新日期：1986-01-01 00:00:00

abstract：:Co-stimulation of highly purified peripheral T lymphocytes from healthy blood donors with the adhesion molecules CD2 and CD28 in association with recombinant interleukin-7 (rIL-7) induced T-cell proliferation, multiple cytokine secretion and IL-2 receptivity. We demonstrated that rIL-7 is as potent as rIL-2 in inducin...

journal_title：Immunology

authors： Costello R,Brailly H,Mallet F,Mawas C,Olive D

更新日期：1993-11-01 00:00:00

abstract：:It is important to identify characteristics that confer on proteins the potential to induce allergenic sensitization and allergenic disease. Protein allergens carry T-cell epitopes that are capable of inducing a type 2 T helper (Th2) cell response. There is limited information regarding factors that govern the allerge...

journal_title：Immunology

authors： So T,Ito H,Hirata M,Ueda T,Imoto T

更新日期：2001-11-01 00:00:00

abstract：:Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-spe...

journal_title：Immunology

authors： Elrefaei M,El-Sheikh N,Kamal K,Cao H

更新日期：2003-12-01 00:00:00

abstract：:GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT c...

journal_title：Immunology

authors： Park JE,Wu DY,Prendes M,Lu SX,Ragupathi G,Schrantz N,Chapman PB

更新日期：2008-01-01 00:00:00

abstract：:In this study we aimed to elucidate the physiological role of gammadelta intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vgamma4/Vdelta5 transgenic mice (KN 6 Tg: BALB/c background, H-2d), and compared the immunological and physiological characteristics of the ...

journal_title：Immunology

authors： Matsumoto S,Nanno M,Watanabe N,Miyashita M,Amasaki H,Suzuki K,Umesaki Y

更新日期：1999-05-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Donor T cells are crucial for target organ injury in graft-versus-host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent-into-F1 model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical...

journal_title：Immunology

authors： Kataoka Y,Iwasaki T,Kuroiwa T,Seto Y,Iwata N,Hashimoto N,Ogata A,Hamano T,Kakishita E

更新日期：2001-07-01 00:00:00

abstract：:The expression of granule proteinases by murine bone marrow-derived mast cells (BMMC) grown in vitro was compared with that of serosal mast cells (SMC) from the peritoneal cavity. The granules in a proportion of BMMC (0.4-13%) and in all SMC were labelled with fluorescent antibodies against rat mast cell protease I (R...

journal_title：Immunology

authors： Newlands GF,Lammas DA,Huntley JF,MacKellar A,Wakelin D,Miller HR

更新日期：1991-03-01 00:00:00

abstract：:In order to identify and characterize the sheep major histocompatibility complex (MHC) class II molecules, a panel of 19 monoclonal antibodies (mAb) has been raised following immunization of mice with a variety of class II antigen preparations. Antibodies were selected by ELISA using immunopurified sheep class II as a...

journal_title：Immunology

authors： Dutia BM,Hopkins J,Allington MP,Bujdoso R,McConnell I

更新日期：1990-05-01 00:00:00

abstract：:Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulat...

journal_title：Immunology

authors： Xiong P,Sang HW,Zhu M

更新日期：2015-11-01 00:00:00

abstract：:The effect of intravenous (i.v.) administration of bacterial alpha-amylase (B alpha A) on the IgG antibody response to a subsequent challenge with B alpha A in incomplete Freund's adjuvant (IFA) varied with the difference in responsiveness of the parental strains. High-responder C3H/He (C3) mice given injections of ei...

journal_title：Immunology

authors： Nakashima S

更新日期：1986-02-01 00:00:00

abstract：:Post-translational modifications of histone proteins are major mechanisms that modify chromatin structure and regulate gene expression in eukaryotes. Activation of histone acetyltransferases or inhibition of histone deacetylases (HDACs) is generally believed to allow chromatin to assume a more open state, permitting t...

journal_title：Immunology

authors： Bode KA,Schroder K,Hume DA,Ravasi T,Heeg K,Sweet MJ,Dalpke AH

更新日期：2007-12-01 00:00:00

abstract：:Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), enables antigen recognition and mediates appropriate immune responses. Distinct subsets of human DCs have been...

journal_title：Immunology

authors： Lundberg K,Rydnert F,Greiff L,Lindstedt M

更新日期：2014-06-01 00:00:00

abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...

journal_title：Immunology

authors： Baumann A,Gönnenwein S,Bischoff SC,Sherman H,Chapnik N,Froy O,Lorentz A

更新日期：2013-12-01 00:00:00

abstract：:Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...

journal_title：Immunology

authors： Cauwe B,Tian L,Franckaert D,Pierson W,Staats KA,Schlenner SM,Liston A

更新日期：2014-03-01 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx), which catalyses the reduction to hydrogen peroxide, small-chain org...

journal_title：Immunology

authors： Girard MC,Acevedo GR,López L,Ossowski MS,Piñeyro MD,Grosso JP,Fernandez M,Hernández Vasquez Y,Robello C,Gómez KA

更新日期：2018-11-01 00:00:00

abstract：:Phagocytosis is a fundamental process in innate resistance to infection. We have used the pathogenic yeast Cryptococcus neoformans to study the interaction of this encapsulated organism with murine macrophages in vitro. In the absence of exogenous opsonins the encapsulated yeast is almost totally resistant to ingestio...

journal_title：Immunology

authors： Cross CE,Collins HL,Bancroft GJ

更新日期：1997-06-01 00:00:00

abstract：:The non-specific normal immunosuppressive protein (Nip) has been described in our laboratory and its biological activity was extensively studied. In the present study, further purification analyses of Nip were conducted. Fractionation of Nip by Ultrogel AcA 34 column resulted in peak (I) that displayed Nip activity in...

journal_title：Immunology

authors： Gavison-Goren R,Nelken D

更新日期：1983-08-01 00:00:00