Abstract：
:Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulator of NK cell biology. DNAM-1 is involved in NK cell education and differentiation, and also plays a pivotal role in the development of cancer, viral infections and immune-related diseases. However, tumours and viruses have developed multiple mechanisms to evade the immune system. They are able to impair DNAM-1 activity by targeting the DNAM-1 receptor-ligand system. We have reviewed the roles of DNAM-1, and its biological functions, with respect to NK cell biology and DNAM-1 chimeric antigen receptor-based immunotherapy.
journal_name
Immunologyjournal_title
Immunologyauthors
Xiong P,Sang HW,Zhu Mdoi
10.1111/imm.12516subject
Has Abstractpub_date
2015-11-01 00:00:00pages
369-78issue
3eissn
0019-2805issn
1365-2567journal_volume
146pub_type
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