The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes.

abstract：:In mice, the plasma cell (PC) niche in the bone marrow is close to the haematopoietic stem cell (HSC) niche. We investigated whether PCs can be mobilized into the peripheral blood (PB) in healthy donors receiving granulocyte colony-stimulating factor (G-CSF) for the induction of HSC mobilization into the PB. G-CSF inc...

journal_title：Immunology

authors： Caraux A,Perez-Andres M,Larroque M,Requirand G,Lu ZY,Kanouni T,Rossi JF,Orfao A,Klein B

更新日期：2011-02-01 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) of infectious bovine rhinotracheitis (IBR)-infected bovine kidney cells (MDBK) by neutrophils was demonstrated. Neutrophils from bovine and sheep mammary exudate and peripheral blood, and also from human peripheral blood, were all active in the presence of anti-IBR ...

journal_title：Immunology

authors： Thorne KJ,Norman JM,Haydock SF,Lammas DA,Duffus PH

更新日期：1984-10-01 00:00:00

abstract：:Type A chrysotile fibres (white asbestos) were tested in vitro for activation of the complement system. Fibres were incubated in normal human serum (NHS), factor B-depleted human serum, and normal and C4-deficient guinea-pig sera; the supernates were assayed for the remaining complement activity. Activation of the alt...

journal_title：Immunology

authors： Saint-Remy JM,Cole P

更新日期：1980-10-01 00:00:00

abstract：:It has previously been shown in mice that activated peritoneal macrophages, when first removed from the peritoneal cavity, suppress mitogen-stimulated lymphocyte transformation in vitro as measured by [3H]-thymidine incorporation. In this study, it is demonstrated that activated macrophages that have been incubated al...

journal_title：Immunology

authors： Wing EJ,Remington JS

更新日期：1980-06-01 00:00:00

abstract：:We have previously shown that retinoids can induce differentiation of B cells in vitro as well as in vivo in patients with common variable immunodeficiency (CVI). While changes were observed over 1 week when retinoic acid (RA) was added to CVI hybridoma cells in vitro, maturation of the patients' B-cell compartment in...

journal_title：Immunology

authors： Saxon A,Keld B,Braun J,Dotson A,Sidell N

更新日期：1993-11-01 00:00:00

abstract：:The nature of the Fc receptors for IgG subclasses displayed on the epithelium of the small intestine in neonatal rats was examined by comparing results gained from 125I-IgG binding studies using isolated enterocyte brush borders, and from experiments where in vivo transmission from the gut to the bloodstream was quant...

journal_title：Immunology

authors： Peppard JV,Jackson LE,Mackenzie NM

更新日期：1985-09-01 00:00:00

abstract：:Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...

journal_title：Immunology

authors： Russell MW,Challacombe SJ,Lehner T

更新日期：1976-05-01 00:00:00

abstract：:The activation of macrophages by various stimuli leading to chemotactic migration and phagocytosis is known to be mediated by an increase in intracellular Ca2+ concentration ([Ca2+]i). We measured changes in [Ca2+]i using a Ca2+ imaging method in individual human macrophages differentiated from freshly prepared periph...

journal_title：Immunology

authors： Oshimi Y,Miyazaki S,Oda S

更新日期：1999-10-01 00:00:00

abstract：:Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all fo...

journal_title：Immunology

authors： Redman CW,McMichael AJ,Stirrat GM,Sunderland CA,Ting A

更新日期：1984-07-01 00:00:00

abstract：:Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine rele...

journal_title：Immunology

authors： Duravetz J,Baumal R,Broder I

更新日期：1976-01-01 00:00:00

abstract：:Chemokine-mediated signalling involves the activation of a Janus kinase (Jak) pathway. We have previously shown that Jak3 mediates CCR9 and CXCR4 signalling in response to CCL25 and CXCL12 in BM progenitors and thymocytes. The lack of peripheral lymph nodes and Peyer's patches observed in Jak3(-/-) mice suggested a po...

journal_title：Immunology

authors： García-Zepeda EA,Licona-Limón I,Jiménez-Sólomon MF,Soldevila G

更新日期：2007-10-01 00:00:00

abstract：:The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...

journal_title：Immunology

authors： Crookshank JA,Patrick C,Wang GS,Noel JA,Scott FW

更新日期：2015-07-01 00:00:00

abstract：:The cytokine interleukin-12 (IL-12) is essential for resistance to Trypanosoma cruzi infection because it stimulates the synthesis of interferon-gamma (IFN-gamma), a major activator of the parasiticidal effect of macrophages. A less studied property of IL-12 is its ability to amplify the proliferation of T or natural ...

journal_title：Immunology

authors： Galvão da Silva AP,de Almeida Abrahamsohn I

更新日期：2001-11-01 00:00:00

abstract：:Efferent lymph from the popliteal node of sheep challenged with antigen was found to suppress the in vitro transformation of sheep peripheral blood lymphocytes to a variety of antigens. The suppressor factor appeared 6-20 hr after challenged of the node and was shown to be prostaglandin E2, probably complexed to album...

journal_title：Immunology

authors： Hopkins J,McConnell I,Raniwalla J

更新日期：1981-05-01 00:00:00

abstract：:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed ...

journal_title：Immunology

authors： Hübner MP,Stocker JT,Mitre E

更新日期：2009-08-01 00:00:00

abstract：:Dendritic cells (DC) isolated from the lymph nodes or spleens of mice and pulsed with contact sensitizers or protein antigens stimulate primary proliferative responses by syngeneic T cells and responses to alloantigens in the mixed leucocyte reaction (MLR). Using enriched human peripheral blood DC, we attempted to sti...

journal_title：Immunology

authors： Hill S,Coates JP,Kimber I,Knight SC

更新日期：1994-10-01 00:00:00

abstract：:An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following ...

journal_title：Immunology

authors： Champion BR,Hutchings P,Davies S,Marshall-Clarke S,Cooke A,Roitt IM

更新日期：1986-05-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests s...

journal_title：Immunology

authors： Thestrup-Pedersen K

更新日期：1975-02-01 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:To determine the influence of anti-idiotypic antibodies on the complementary idiotype (Id), the clearance kinetics, tissue distribution and fate of idiotype-anti-idiotype complexes were investigated in mice. The complexes were prepared by mixing purified radiolabelled monomeric (mIgA) or polymeric IgA (pIgA) with mono...

journal_title：Immunology

authors： Rifai A,Wu CG

更新日期：1990-04-01 00:00:00

abstract：:The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to...

journal_title：Immunology

authors： Martin S,Rothe H,Tschöpe D,Schwippert B,Kolb H

更新日期：1991-05-01 00:00:00

abstract：:Deficiency in gammadelta T cells aggravates colitis in animal models suggesting that gammadelta T cells have regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human gammadelta T cells were determined in vitro. Human peripheral gammadelta T cells were isolated from the whole blood o...

journal_title：Immunology

authors： Kühl AA,Pawlowski NN,Grollich K,Blessenohl M,Westermann J,Zeitz M,Loddenkemper C,Hoffmann JC

更新日期：2009-12-01 00:00:00

abstract：:T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can reverse overt disease in spontaneously diabetic non-obese diabetic mice, an effect proposed to, at least in part, be caused by a selec...

journal_title：Immunology

authors： Wallberg M,Recino A,Phillips J,Howie D,Vienne M,Paluch C,Azuma M,Wong FS,Waldmann H,Cooke A

更新日期：2017-06-01 00:00:00

abstract：:Antigen-specific T-helper factor (ThF) bears I-A determinants and is I-A restricted in its action. This I-A restriction may be explained by ThF binding, and hence approximating antigen to its own I-A determinants, thereby facilitating recognition by the T cell (I-A presentation theory), or by a recognition site for I-...

journal_title：Immunology

authors： Little JA,Asherson GL

更新日期：1987-11-01 00:00:00

abstract：:We have confirmed previous observations that intestinal anaphylaxis induced in rats previously sensitized to ovalbumin (OVA) is associated with an increased uptake of an unrelated 'bystander' protein, bovine serum albumin (BSA) fed 1 hr previously. In this study, this enhanced protein uptake was associated with an inc...

journal_title：Immunology

authors： Turner MW,Boulton P,Shields JG,Strobel S,Gibson S,Miller HR,Levinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:Previous studies have shown that depletion of Langerhans' cells (LC) from murine epidermis by the superantigen, staphylococcal enterotoxin A (SEA) involves interleukin-1alpha (IL-1alpha) and is inhibitable by agents that block G-protein-associated kinases. The purpose of this study was to determine whether specific ki...

journal_title：Immunology

authors： Shankar G,Johnson J,Kuschel L,Richins M,Burnham K

更新日期：1999-02-01 00:00:00

abstract：:Simultaneous kinetic measurements have been made of basophil degranulation and of histamine release. Both antigen and ionophore A23187 were studied. Cells from the same donor under the same conditions undergo both reactions at a similar rate. Regression analysis indicated a statistically highly significant correlation...

journal_title：Immunology

authors： Pruzansky JJ,Zeiss CR,Patterson R

更新日期：1980-07-01 00:00:00

abstract：:Dendritic cells (DC) are powerful inducers of primary T-cell responses, but their role in secondary responses has not been extensively analysed. Here, we address the role of two DC subsets derived from human CD16(+) (16(+) mDC) or CD16(-) (16(-) mDC) monocytes on the reactivation of memory responses. CD4(+) CD45RA(-) ...

journal_title：Immunology

authors： Bajaña S,Herrera-González N,Narváez J,Torres-Aguilar H,Rivas-Carvalho A,Aguilar SR,Sánchez-Torres C

更新日期：2007-11-01 00:00:00

abstract：:Following exposure of mice to contact sensitizing chemicals, dendritic cells (DC) rapidly accumulate in the draining lymph nodes. A proportion, at least, of the DC which arrive in the nodes bear significant amounts of antigen and are derived from epidermal Langerhans' cells (LC). It is of interest that although LC are...

journal_title：Immunology

authors： Cumberbatch M,Gould SJ,Peters SW,Kimber I

更新日期：1991-11-01 00:00:00