Abstract：
:Efferent lymph from the popliteal node of sheep challenged with antigen was found to suppress the in vitro transformation of sheep peripheral blood lymphocytes to a variety of antigens. The suppressor factor appeared 6-20 hr after challenged of the node and was shown to be prostaglandin E2, probably complexed to albumin.
journal_name
Immunologyjournal_title
Immunologyauthors
Hopkins J,McConnell I,Raniwalla Jsubject
Has Abstractpub_date
1981-05-01 00:00:00pages
205-12issue
1eissn
0019-2805issn
1365-2567journal_volume
43pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as thr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Heat or chemically aggregated IgA or IgG stimulated degranulation of neutrophils with comparable efficiency. The same aggregates induced a neutrophil respiratory burst which could be measured by lucigenin-enhanced chemiluminescence. Serum IgA1 or IgA2 coated onto microtitre plates were both capable of inducing a respi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:The antibody response in rhino mice, which carry a mutant gene hrrh, to thymus-dependent (TD) or thymus-independent (TI) antigens was compared with that of phenotypically normal littermates. The magnitude of antibody response to TD antigens in rhino mice decreased as they grew up, whereas the antibody response to TI a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:The balance between pro- and anti-inflammatory cytokines has been implicated in the pathogenesis of infectious and auto-immune diseases, and its modulation has been proposed as a potential therapeutic target. The results reported in the present study show that modulators of the renin-angiotensin system, such as the an...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00524.x
更新日期：1998-07-01 00:00:00
abstract：:This study addresses the question of whether human peripheral CD4+ CD45RA+ T cells possess antigen-specific immune memory. CD4+ CD45RA+ T cells were isolated by a combination of positive and negative selection. Putative CD4+ CD45RA+ cells expressed CD45RA (98.9%) and contained < 0.1% CD4+ CD45RO+ and < 0.5% CD4+ CD45R...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00274.x
更新日期：1997-07-01 00:00:00
abstract：:Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:A technique is reported here for the quantitative extraction of live cells from the lung interstitium; it involves the incubation of slices of perfused lung in a mixture containing optimal concentrations of collagenase, DNAse, and fetal calf serum, followed by the simultaneous recovery and fractionation of cells relea...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：:It has previously been demonstrated that a gene on chromosome 1 in or near Mls-1 controls, on the surface of B cells, the mobility and aggregability of major histocompatibility complex (MHC) class II molecules but not the mobility or aggregability of other B-cell molecules, such as immunoglobulin (Ig) and class I anti...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Immunization with intact IgG has allowed the isolation of four hybridomas producing antibodies recognizing epitopes expressed within subpopulations of human kappa light chains unrelated to known polymorphisms (Km) and previously defined V-region subgroups. The V-region-associated epitopes recognized are conformation-d...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Rabbit spleen and mesenteric lymph node cells were treated with a monoclonal anti-rabbit T-lymphocyte antibody (MAb) and complement and the effect of the treatment on various lymphocyte functions was determined. Lysis of spleen and mesenteric lymph node cells reactive with this MAb, 9AE10, essentially eliminated their...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) catalyse the formation of hypochlorite (OCl-) from chloride ions (OCl-) and hydrogen peroxide (H2O2). OCl- proved to be highly toxic for Trichinella spiralis newborn larvae (NBL) in in vitro assays. Using purified human MPO and EPO it was found that even at neutral...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Colorectal cancer is considered a non-immunogenic malignany. One strategy to augment the immunogenicity of such tumours is represented by the expression of costimulatory molecules by gene transfer. Using transfected variants of the human colorectal cancer cell line SW480 we tested various costimulatory molecules (CD80...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00450.x
更新日期：1998-03-01 00:00:00
abstract：:Our goal was to study the small lymphocytes that were recruited to cutaneous DTH lesions in order to determine if there existed a subset of small lymphocytes which preferentially migrated into cutaneous inflammatory sites rather than into lymphoid tissues. Lymphocytes were radiolabelled and injected i.v. into sensitiz...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02620.x
更新日期：2007-09-01 00:00:00
abstract：:Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell ...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/imm.12061
更新日期：2013-05-01 00:00:00
abstract：:Dendritic cells (DC) isolated from the lymph nodes or spleens of mice and pulsed with contact sensitizers or protein antigens stimulate primary proliferative responses by syngeneic T cells and responses to alloantigens in the mixed leucocyte reaction (MLR). Using enriched human peripheral blood DC, we attempted to sti...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with BCG or/and trypan blue before immunization with a hapten-carrier complex. The results show that it is possible to induce, with BCG, at the beginning of the response, an antigeni...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
abstract：:Lipoprotein lipase (LPL) is the key enzyme in the metabolism of triglyceride-rich lipoproteins. The patterns of LPL mRNA expression and secretion of the enzyme have not yet been established in natural killer (NK) cells. We show in the present communication that CD3- CD16+ cells (NK cells) transcribe LPL mRNA, express ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Regulatory T (Treg) cells act to suppress activation of the immune system and thereby maintain immunological homeostasis and tolerance to self-antigens. The frequency and suppressing activity of Treg cells in general are high in different malignancies. We wanted to identify the role and regulation of CD4(+) CD25(+) ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12237
更新日期：2014-05-01 00:00:00
abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01438.x
更新日期：2002-07-01 00:00:00
abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12994
更新日期：2018-12-01 00:00:00
abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00352.x
更新日期：1997-11-01 00:00:00
abstract：:An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Using cloned human helper T lymphocytes reactive with a 24 amino acid peptide (p20) of the carboxyl terminal of the HA-1 molecule of influenza haemagglutinin we have investigated the influence of antigen structure on the activation and in the induction of antigen specific unresponsiveness of T cells. For this analysis...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
