Lipoprotein lipase expression in natural killer cells and its role in their cytotoxic activity.

abstract：:Staphylococcal enterotoxins (SE) are potent T-lymphocyte activators that stimulate T cells by directly cross-linking HLA-DR molecules on antigen-presenting cells with the V beta gene products of the T-cell receptor. The different SE activate all T cells expressing a given V beta, and, therefore, have been termed 'supe...

journal_title：Immunology

authors： Duan X,Nerl C,Janssen O,Kabelitz D

更新日期：1992-03-01 00:00:00

abstract：:Testing of extracts of Toxoplasma gondii (RH strain) indicated that delayed hypersensitivity as manifested by delayed skin reactions and inhibition of macrophage migration was induced only by those fractions containing RNA. ...

journal_title：Immunology

authors： Lai CH,Tizard IR,Quinn PJ,Ingram DG

更新日期：1975-04-01 00:00:00

abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

journal_title：Immunology

authors： Brandtzaeg P

更新日期：1975-09-01 00:00:00

abstract：:Mice injected intravenously with a high dose (5 X 10(7) ) of BCG fail to develop delayed hypersensitivity to BCG and are described as anergic or unresponsive. Spleen cells from these mice release factors on culture which suppress DNA synthesis induced by concanavalin A in vitro. Cell separation experiments showed that...

journal_title：Immunology

authors： Colizzi V,Ferluga J,Garreau F,Malkovsky M,Asherson GL

更新日期：1984-01-01 00:00:00

abstract：:Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an anima...

journal_title：Immunology

authors： Han B,Zhang YY,Ye ZQ,Xiao Y,Rasouli J,Wu WC,Ye SM,Guo XY,Zhu L,Rostami A,Wang LB,Zhang Y,Li X

更新日期：2021-01-22 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:Specific and non-specific IgE antibody responses were studied in SD rats infected with between 5 and 2500 Nippostrongylus brasiliensis (NB) larvae. In rats with 2500 NB larvae, specific IgE antibody, measured by enzyme-linked immunosorbent assay (ELISA) using NB excretory/secretory substance as antigen, reached a peak...

journal_title：Immunology

authors： Yamada M,Nakazawa M,Kamata I,Arizono N

更新日期：1992-01-01 00:00:00

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00

abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...

journal_title：Immunology

authors： Mühlbauer M,Cheely AW,Yenugu S,Jobin C

更新日期：2008-06-01 00:00:00

abstract：:The adult cockroach generates an adaptive humoral immune response exhibiting specificity and immunological memory when immunized with soluble proteins. In contrast, the response induced by bacteria in holometabolous insects is non-specific and short term, generally losing activity after 72 hr. We have found that the r...

journal_title：Immunology

authors： Faulhaber LM,Karp RD

更新日期：1992-02-01 00:00:00

abstract：:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior sy...

journal_title：Immunology

authors： Yang X,Wang S,Fan Y,Zhu L

更新日期：1999-11-01 00:00:00

abstract：:The discovery that corticosteroids can alter leucocyte distribution implies that suppression of PFC in the spleen is not necessarily indicative of suppression of the antibody response as a whole. Therefore we have examined IgM and IgG serum antibodies and PFC in the thymus, spleen, femoral marrow, popliteal, thoracic ...

journal_title：Immunology

authors： Dracott BN,Smith CE

更新日期：1979-10-01 00:00:00

abstract：:Experiments were conducted to test the hypothesis that opsonic and non-opsonic phagocytic capacities are differentially regulated by resting and wound-derived macrophages. Furthermore, the phagocytosis of non-opsonized zymosan and beta-glucan particles was quantified to determine whether cells differentially regulate ...

journal_title：Immunology

authors： Reichner JS,Fitzpatrick PA,Wakshull E,Albina JE

更新日期：2001-10-01 00:00:00

abstract：:The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...

journal_title：Immunology

authors： Hamilton SR,Keren DF,Yardley JH,Brown G

更新日期：1981-03-01 00:00:00

abstract：:The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single injection of antigen was found to increase during the first 6 weeks of life. The responses of 1- and 2-week-old animals als...

journal_title：Immunology

authors： Marshall-Clarke S,Playfair JH

更新日期：1975-09-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:In an attempt to produce monoclonal antibodies against human large granular lymphocytes (LGL), the effector cells of natural killer (NK) and killer (K) activity, a monoclonal IgM antibody (VEP10) has been obtained. This antibody is reactive by indirect membrane immunofluorescence (IMF) with 14.7 +/- 8.5% peripheral bl...

journal_title：Immunology

authors： Rumpold H,Kraft D,Obexer G,Böck G,Möschl P

更新日期：1983-06-01 00:00:00

abstract：:Antisera were prepared against a variety of chicken tissues with a view to detecting antigens specific for subpopulations of T and B cells at different maturation stages. By appropriate absorption analysis, the following antigens were defined: (a) thymus organ-specific antigen (CTOA); (b) T lymphocyte-specific antigen...

journal_title：Immunology

authors： Boyd RL,Ward HA

更新日期：1978-01-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...

journal_title：Immunology

authors： De Boer OJ,Horst E,Pals ST,Bos JD,Das PK

更新日期：1994-03-01 00:00:00

abstract：:Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-spe...

journal_title：Immunology

authors： Elrefaei M,El-Sheikh N,Kamal K,Cao H

更新日期：2003-12-01 00:00:00

abstract：:Protectin (CD59) is a glycolipid-anchored inhibitor of the membrane attack complex (MAC) of human complement (C) that protects blood cells, endothelial cells and various epithelial cells from C-mediated lysis. Because of its activities protectin is a candidate molecule for use in the treatment of paroxysmal nocturnal ...

journal_title：Immunology

authors： Hakulinen J,Meri S

更新日期：1995-07-01 00:00:00

abstract：:The levels of IgM, IgA and IgG secreting cells were examined in control, Corynebacterium parvum-stimulated and tumour-bearing, normal and athymic (Nu/Nu) mice. The percentage of IgA to IgM or IgG secreting cells is relatively higher in peripheral blood than in the spleen or peritoneum of normal mice. Within tumours, i...

journal_title：Immunology

authors： Howie S,McBride WH,James K

更新日期：1982-05-01 00:00:00

abstract：:The inhibitory effects of IgA from human colostrum, and IgA1 and IgA2 from human serum on the chemiluminescence (CL) response and phagocytosis of polymorphonuclear leucocytes (PML) to Staphylococcus epidermidis and the CL response to formylmethionyl-leucyl-phenylalanine (FMLP) were studied. The dose-dependent inhibiti...

journal_title：Immunology

authors： Saito K,Kato C,Katsuragi H,Komatsuzaki A

更新日期：1991-09-01 00:00:00

abstract：:Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro-inflammatory cytokine interleukin(IL)-1β. Here, primarily using an in vitro inflammasome ASC spec...

journal_title：Immunology

authors： Nizami S,Arunasalam K,Green J,Cook J,Lawrence CB,Zarganes-Tzitzikas T,Davis JB,Di Daniel E,Brough D

更新日期：2021-01-01 00:00:00

abstract：:We studied the generation and metabolism of leukotrienes (LTs) in human lung macrophages obtained from lung tissue of patients with central bronchial carcinoma. By counterflow centrifugation macrophages were enriched with a purity of more than 95-100%. A time and dose dependent generation of LTB4 and LTC4 was determin...

journal_title：Immunology

authors： Schönfeld W,Schlüter B,Hilger R,König W

更新日期：1988-12-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:The IgE antibody responses of inbred BALB/c mice to subcutaneously injected antigens, given without adjuvant, were studied. Cocksfoot grass pollen extract (GPE) (100-100,000 pnu) induced no detectable primary IgE antibody responses but following second and subsequent injections, substantial secondary responses were pr...

journal_title：Immunology

authors： Taylor WA,Sheldon D,Francis DH

更新日期：1980-04-01 00:00:00

abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...

journal_title：Immunology

authors： Suen JL,Chuang YH,Chiang BL

更新日期：2002-07-01 00:00:00

abstract：:Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the...

journal_title：Immunology

authors： Dourmashkin RR

更新日期：1978-08-01 00:00:00