Enhancement of immunogenicity of tumour virus antigen by liposomes: the effect of lipid composition.

abstract：:Expression of Fc gamma receptors on human placental trophoblast was investigated by immunostaining and immunoblotting using a panel of Fc gamma receptor monoclonal antibodies (mAb). Fc gamma receptors typical of other cell types were not detected on syncytiotrophoblast in term placentae when transplacental IgG transpo...

journal_title：Immunology

authors： Wainwright SD,Holmes CH

更新日期：1993-11-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...

journal_title：Immunology

authors： Webb LM,Foxwell BM,Feldmann M

更新日期：1999-11-01 00:00:00

abstract：:We studied the hs1,2 transcriptional enhancer identified downstream of the human alpha1 gene of the immunoglobulin H (IgH) locus, for which two different allelic configurations (a and b) were previously reported by Southern blotting. By using a polymerase chain reaction (PCR) method we amplified minisatellites within ...

journal_title：Immunology

authors： Denizot Y,Pinaud E,Aupetit C,Le Morvan C,Magnoux E,Aldigier JC,Cogné M

更新日期：2001-05-01 00:00:00

abstract：:We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...

journal_title：Immunology

authors： Shinomiya T,Li XK,Amemiya H,Suzuki S

更新日期：1997-08-01 00:00:00

abstract：:Mast cell secretory granules contain unique tryptic and chymotryptic serine proteases that differ between species and tissues. Direct comparison of these proteases in single-cell types has been hindered by the difficulty of obtaining adequate numbers of pure mast cells. In this study, we were able to compare tryptic a...

journal_title：Immunology

authors： Caughey GH,Lazarus SC,Viro NF,Gold WM,Nadel JA

更新日期：1988-02-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T helper cell, and CD8+ cytotoxic T lymphocyte (CTL) responses upon ado...

journal_title：Immunology

authors： Kapp JA,Kapp LM,McKenna KC,Lake JP

更新日期：2004-02-01 00:00:00

abstract：:Delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with BCG or/and trypan blue before immunization with a hapten-carrier complex. The results show that it is possible to induce, with BCG, at the beginning of the response, an antigeni...

journal_title：Immunology

authors： Neveu PJ

更新日期：1977-08-01 00:00:00

abstract：:The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...

journal_title：Immunology

authors： Inagaki-Ohara K,Sakamoto Y,Dohi T,Smith AL

更新日期：2011-12-01 00:00:00

abstract：:Secretory proteins of Mycobacterium tuberculosis are the major immunomodulators of the host immune response. Open reading frame (ORF) Rv2626c, encoding a conserved hypothetical protein eliciting a strong humoral immune response in patients with tuberculosis (TB), was shown to be up-regulated upon infection in mice und...

journal_title：Immunology

authors： Bashir N,Kounsar F,Mukhopadhyay S,Hasnain SE

更新日期：2010-05-01 00:00:00

abstract：:Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible Mls-disparate strain combinations of AKR/J(H-2k,Thy-1.1,Mls-1a) and C3H/He(H-2k,Thy-1.2,Mls-1b). In order to determine further th...

journal_title：Immunology

authors： Ogimoto M,Yoshikai Y,Matsuzaki G,Ohga S,Matsumoto K,Nomoto K

更新日期：1990-03-01 00:00:00

abstract：:The expression of adhesion molecules on vascular endothelial cells determines the pattern of migration and extravasation of leucocytes in inflammation and immunity. Here we show that costimulation with CD40 ligand (CD40L) and interleukin (IL)-4 (or IL-13) gives rise to a unique pattern of adhesion molecule expression ...

journal_title：Immunology

authors： Kotowicz K,Dixon GL,Klein NJ,Peters MJ,Callard RE

更新日期：2000-08-01 00:00:00

abstract：:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...

journal_title：Immunology

authors： Ostman S,Taube M,Telemo E

更新日期：2005-12-01 00:00:00

abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...

journal_title：Immunology

authors： Suen JL,Chuang YH,Chiang BL

更新日期：2002-07-01 00:00:00

abstract：:Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytoplasmic CTLA-4 (cCTLA-4)...

journal_title：Immunology

authors： Karabon L,Kosmaczewska A,Bilinska M,Pawlak E,Ciszak L,Jedynak A,Jonkisz A,Noga L,Pokryszko-Dragan A,Koszewicz M,Frydecka I

更新日期：2009-09-01 00:00:00

abstract：:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this pap...

journal_title：Immunology

authors： Storch W,Cossel L,Dargel R

更新日期：1977-06-01 00:00:00

abstract：:The ability to expand tumour-infiltrating lymphocytes in vitro has been greatly enhanced by the use of antigen-independent mechanisms of immune cell costimulation. We have produced human, using the K562 cell line, and murine, using YAC-1 cells, artificial antigen presenting cells (aAPC) and demonstrate that these cell...

journal_title：Immunology

authors： Yan X,Johnson BD,Orentas RJ

更新日期：2004-05-01 00:00:00

abstract：:Prolonged exposure to ultraviolet light (UV) is known to lead to premature skin ageing, increased incidence of cataract and a high risk of developing skin cancers. UV-B irradiation, even if given as a single suberythemal dose, suppresses some immune responses, possibly reducing the production of T helper (Th) 1 cytoki...

journal_title：Immunology

authors： el-Ghorr AA,Norval M

更新日期：1997-09-01 00:00:00

abstract：:Doxorubicin-stimulated whole rat glomeruli and dissociated mesangial and resident glomerular macrophage cells produced the release of interleukin (IL)-1 beta cytokine. This activity increased after the addition of lipopolysaccharide (LPS) or LPS plus indomethacin to the cultures. In the presence of WEB2086 [platelet-a...

journal_title：Immunology

authors： Bricio T,Molina A,Martin A,Mampaso F

更新日期：1994-01-01 00:00:00

abstract：:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and m...

journal_title：Immunology

authors： Flexman JP,Shellam GR,Mayrhofer G

更新日期：1983-04-01 00:00:00

abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...

journal_title：Immunology

authors： Ianaro A,O'Donnell CA,Di Rosa M,Liew FY

更新日期：1994-07-01 00:00:00

abstract：:Expression of the lymph node homing and CC-chemokine receptor 7 (CCR7), with L-selectin (CD62L), has been shown to divide human memory T cells into two functionally distinct subsets. We generated a polyclonal antibody against murine CCR7 and used this antibody to study CCR7 expression on murine T-cell subsets. Using f...

journal_title：Immunology

authors： Bjorkdahl O,Barber KA,Brett SJ,Daly MG,Plumpton C,Elshourbagy NA,Tite JP,Thomsen LL

更新日期：2003-10-01 00:00:00

abstract：:MCA44 is a monoclonal antibody (mAb) to guinea-pig decay-accelerating factor (DAF) and, using this mAb, tissue distribution of guinea-pig DAF was studied by immunofluorescence. Guinea-pig DAF was found to be expressed not only on the vascular endothelium but also on different types of cells, such as the tubular epithe...

journal_title：Immunology

authors： Nishikawa K,Matsuo S,Tamai H,Okada N,Okada H

更新日期：1998-10-01 00:00:00

abstract：:Veiled cells (VC), isolated from the thoracic duct of irradiated lymphadenectomized mice (MLNX) or peritoneal macrophages (PM phi were incubated with isotope-labelled hen egg lysozyme (HEL), purified protein derivative (PPD) or keyhole limpet haemocyanin (KLH) in vitro. About 2-10 times less antigen was associated wit...

journal_title：Immunology

authors： Rhodes JM,Balfour BM,Blom J,Agger R

更新日期：1989-11-01 00:00:00

abstract：:Bovine tuberculosis, which persists as a residual level of infection in many European countries, has implications not only for the economy of farming communities but also for human health. The aim of this study was to identify a common mycobacterial antigen which was recognized in bovine tuberculosis and to characteri...

journal_title：Immunology

authors： Lightbody KA,Girvin RM,Pollock DA,Mackie DP,Neill SD,Pollock JM

更新日期：1998-03-01 00:00:00

abstract：:Pre-exposure to bacterial lipopolysaccharide (LPS) or certain cytokines is known to enhance the ability of murine macrophages to generate a respiratory burst in response to subsequent stimulation, a phenomenon referred to as 'priming'. We report here that the cytokine interleukin-4 (IL-4) can prime murine macrophages....

journal_title：Immunology

authors： Phillips WA,Croatto M,Hamilton JA

更新日期：1990-08-01 00:00:00

abstract：:We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/...

journal_title：Immunology

authors： Pedron T,Girard R,Jeyaretnam B,Carlson RW,Chaby R

更新日期：2000-10-01 00:00:00

abstract：:Treatment of patients with septic shock using monoclonal antibodies (mAbs) to endotoxin is still controversial. Clinical trials of E5, one of the mAbs directed against the lipid A moiety of lipopolysaccharide (LPS), are currently in progress. The mechanisms of action of this, and other antibodies under clinical evalua...

journal_title：Immunology

authors： Seelen MA,Athanassiou P,Lynn WA,Norsworthy P,Walport MJ,Cohen J,Davies KA

更新日期：1995-04-01 00:00:00

abstract：:Transport of major histocompatibility complex (MHC) class II molecules to the endocytic route is directed by the associated invariant chain (Ii). In the endocytic pathway, Ii is proteolytically cleaved and, upon removal of residual Ii fragments, class II alpha beta dimers are charged with antigenic peptide and recogni...

journal_title：Immunology

authors： Moldenhauer G,Henne C,Karhausen J,Möller P

更新日期：1999-03-01 00:00:00