Comparison of antigen uptake by peritoneal macrophages and veiled cells from the thoracic duct using isotope-, FITC-, or gold-labelled antigen.

abstract：:The objective of the present study was to examine and to compare the impact of severe protein malnutrition during development, adulthood and ageing on secretory immune expression in the eye, mouth and small intestine. In addition, we sought to determine whether potential abrogation of mucosal immunity by protein depri...

journal_title：Immunology

authors： Sullivan DA,Vaerman JP,Soo C

更新日期：1993-02-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:The localization of Thy-1, MRC OX 2 and Ia antigens as defined by monoclonal antibodies MRC OX 7, MRC OX 2 and MRC OX 6 was determined by an indirect immunoperoxidase technique on cryostat sections of rat ovaries. Thy-1 antigen was present significantly in the theca interna of growing antral follicles. Developing corp...

journal_title：Immunology

authors： Bukovský A,Presl J,Zidovský J,Mancal P

更新日期：1983-03-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...

journal_title：Immunology

authors： Tang X,Mo C,Wang Y,Wei D,Xiao H

更新日期：2013-02-01 00:00:00

abstract：:The innate immune response provides the initial defence mechanism against infection by other organisms. However, an excessive immune response will cause damage to host tissues. In an attempt to identify microRNAs (miRNAs) that regulate the innate immune response in inflammation and homeostasis, we examined the differe...

journal_title：Immunology

authors： Niu Y,Mo D,Qin L,Wang C,Li A,Zhao X,Wang X,Xiao S,Wang Q,Xie Y,He Z,Cong P,Chen Y

更新日期：2011-05-01 00:00:00

abstract：:Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb...

journal_title：Immunology

authors： Crane I,Leung H,Barwick S,Parti S,Meager A

更新日期：1984-12-01 00:00:00

abstract：:The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phy...

journal_title：Immunology

authors： Kicza K,Fischer A,Pfeil T,Bujanowski-Weber J,König W

更新日期：1989-12-01 00:00:00

abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...

journal_title：Immunology

authors： Gerber SA,Sorensen EW,Sedlacek AL,Lim JY,Skrombolas D,Frelinger JG,Lord EM

更新日期：2013-03-01 00:00:00

abstract：:The ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to e...

journal_title：Immunology

authors： Woods GM,Qu M,Ragg SJ,Muller HK

更新日期：1996-05-01 00:00:00

abstract：:We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...

journal_title：Immunology

authors： Zhang Y,Pacheco S,Acuna CL,Switzer KC,Wang Y,Gilmore X,Harriman GR,Mbawuike IN

更新日期：2002-03-01 00:00:00

abstract：:Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...

journal_title：Immunology

authors： Parriott G,Deal K,Crean S,Richardson E,Nylen E,Barber A

更新日期：2020-07-01 00:00:00

abstract：:The expression of granule proteinases by murine bone marrow-derived mast cells (BMMC) grown in vitro was compared with that of serosal mast cells (SMC) from the peritoneal cavity. The granules in a proportion of BMMC (0.4-13%) and in all SMC were labelled with fluorescent antibodies against rat mast cell protease I (R...

journal_title：Immunology

authors： Newlands GF,Lammas DA,Huntley JF,MacKellar A,Wakelin D,Miller HR

更新日期：1991-03-01 00:00:00

abstract：:It has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II-positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstra...

journal_title：Immunology

authors： Igyártó BZ,Lackó E,Oláh I,Magyar A

更新日期：2006-10-01 00:00:00

abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...

journal_title：Immunology

authors： Wines BD,Gavin A,Powell MS,Steinitz M,Buchanan RR,Mark Hogarth P

更新日期：2003-06-01 00:00:00

abstract：:A panel of monoclonal antibodies was used to define the lymphocyte subpopulations in the sheep uterus at various stages of the oestrous cycle. A striking finding was that the majority of lymphocytes in the uterine and endometrial glandular epithelia belonged to a unique lymphocyte subpopulation that expressed the CD45...

journal_title：Immunology

authors： Lee CS,Gogolin-Ewens K,Brandon MR

更新日期：1988-01-01 00:00:00

abstract：:The resistance and susceptibility of T cells to human immunodeficiency virus (HIV)-gp120 induced anergy was examined. Antigen-dependent proliferation of polyclonal T cells was markedly inhibited by gp120, whereas from the analysis of monoclonal populations, T cells resistant to the effects of gp120 could be identified...

journal_title：Immunology

authors： Faith A,O'Hehir RE,Malkovsky M,Lamb JR

更新日期：1992-06-01 00:00:00

abstract：:Within the lesions of inflammatory myopathies, muscle fibres and invading mononuclear cells express Fas and Fas ligand (FasL), respectively. However, the roles of the Fas/FasL interaction in the pathogenesis of inflammatory myopathies are not fully understood. In the present study, we investigated the roles of proinfl...

journal_title：Immunology

authors： Kondo M,Murakawa Y,Harashima N,Kobayashi S,Yamaguchi S,Harada M

更新日期：2009-09-01 00:00:00

abstract：:The IgE immune response was studied in female athymic, nude (Lewis rnu/rnu) and euthymic (Lewis +/+) rats infected with the nematode Nippostrongylus brasiliensis. During the course of the infection, serum IgE levels were followed using an enzyme-linked immunosorbent assay technique (ELISA), while the surface expressio...

journal_title：Immunology

authors： Chen XJ,Wiedermann U,Dahlgren U,Hanson LA,Enerbäck L

更新日期：1995-11-01 00:00:00

abstract：:In Trichinella spiralis-infected rats, a population of cells in thoracic duct lymph (TDL) that can adoptively transfer protection to naive rats was identified and characterized. During the course of T. spiralis infection, blast cells appeared in lymph from Day 3-4, and only Day 3-4 TDL cells had protective properties ...

journal_title：Immunology

authors： Bell RG,Korenaga M,Wang CH

更新日期：1987-06-01 00:00:00

abstract：:The delayed-type-hypersensitivity (DTH) reaction observed in mice primed i.v. with low doses of sheep red blood cells is not detectable after priming with large doses. Estimation of the number of DTH mediating cells (DTH-C) was performed by titration (D50 determination) using local adoptive transfer of these cells mix...

journal_title：Immunology

authors： Marchal G,Milon G,Hurtrel B,Lagrance PH

更新日期：1978-12-01 00:00:00

abstract：:Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concen...

journal_title：Immunology

authors： DiScipio RG

更新日期：1982-03-01 00:00:00

abstract：:A serum factor, believed to be an IgG autoantibody, in certain patients with lepromatous leprosy inhibits the proliferation of mitogen-stimulated lymphocytes. To investigate which stage of the cell cycle was inhibited, we examined the effect of these sera on the kinetics of lymphocyte activation induced by several mit...

journal_title：Immunology

authors： Poulton TA,Gallagher A,Beck JS

更新日期：1989-11-01 00:00:00

abstract：:The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single injection of antigen was found to increase during the first 6 weeks of life. The responses of 1- and 2-week-old animals als...

journal_title：Immunology

authors： Marshall-Clarke S,Playfair JH

更新日期：1975-09-01 00:00:00

abstract：:Previous studies have shown that no cell-mediated immunity against LCM virus-infected cells can be detected in neonatally established LCM virus carrier mice suggesting that they are immunologically tolerant to virally-altered cell membrane antigens. In this communication experiments are described aimed at analyzing th...

journal_title：Immunology

authors： Cihak J,Lehmann-Grube F

更新日期：1978-02-01 00:00:00

abstract：:Dendritic cells (DC) generated from MUTZ-3, an immortalized acute myeloid leukaemia-derived cell line, have potential application as a model for the study of human DC, and as a tool with which to stimulate immunotherapeutic responses to cancer. However, the relationship of MUTZ-3 DC to their non-transformed counterpar...

journal_title：Immunology

authors： Rasaiyaah J,Noursadeghi M,Kellam P,Chain B

更新日期：2009-07-01 00:00:00

abstract：:The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta locus are likely to play an important role. It is assumed that the TCR-delta gene is deleted prior to V alpha-J alpha rearr...

journal_title：Immunology

authors： Verschuren MC,Wolvers-Tettero IL,Breit TM,van Dongen JJ

更新日期：1998-02-01 00:00:00

abstract：:Previous studies have shown that the degradation of soluble immune complexes or aggregates (AIgG) by normal peritoneal macrophages can be enhanced by complement. The enhancement of degradation was shown to be at least in part dependent on the number of C3b molecules bound per complex. The present investigations indica...

journal_title：Immunology

authors： Daha MR,Van Es LA

更新日期：1983-09-01 00:00:00

abstract：:Experiments were designed to determine the in vivo cell-cycle phase of lymphocytes in secondary lymphoid follicles, and whether B-cell proliferation and apoptosis occur within follicular dendritic cell (FDC)-associated clusters. Using frozen serial sections of human tonsils, lymphoid follicles were stained to reveal h...

journal_title：Immunology

authors： Orui H,Yamakawa M,Imai Y

更新日期：1997-04-01 00:00:00

abstract：:We have recently described a bone marrow culture system which is able to maintain a portion of the precursor-T (pre-T) cell compartment of adult murine marrow in vitro, in the presence of interleukin-3 (IL-3), for at least 2 weeks. However, because growth in IL-3 might also induce the differentiation of the pre-T cell...

journal_title：Immunology

authors： Soloff RS,Dempsey D,Jennings SR,Wolcott RM,Chervenak R

更新日期：1992-06-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00