Abstract：
:The cell-cell interactions for CD23 expression and soluble (s)CD23 release from peripheral blood lymphocytes (PBL), as well as purified cells (B, T cells, monocytes) of atopic donors, were studied. Cells either stimulated combined and subsequently separated or stimulated after separation were analysed. IL-4, IL-2, phytohaemagglutinin (PHA), interferon-gamma (IFN-gamma) and the combined interaction of IL-4 and IFN-gamma as well as PHA and IFN-gamma were used as stimuli. sCD23 release in the cell supernatant was determined from cells separated before stimulation. CD23 expression induced by IL-4 on cells stimulated and subsequently separated was significantly lower compared with amounts on separated cells which were subsequently stimulated. Major expression of CD23 was obtained on B cells and monocytes. Stimulation with PHA led to an increased expression on T cells compared to the control. When cells were stimulated, combined and separated, the combined stimuli of IL-4 and IFN-gamma showed a reduced CD23 expression for both experimental procedures and an enhanced release of sCD23. The data suggest an important role for cell-cell interactions. These results were supported by experiments in which separated cells were either co-cultured or cultured in Transwells. Co-culture of T cells with B cells and monocytes suggested that T cells are responsible for suppressed CD23 expression. No or only slight enhancement was obtained for sCD23 release. Our data indicate that cell-cell interactions and cytokines regulate CD23 expression, while sCD23 release is apparently solely regulated by soluble mediators (e.g. cytokines).
journal_name
Immunologyjournal_title
Immunologyauthors
Kicza K,Fischer A,Pfeil T,Bujanowski-Weber J,König Wsubject
Has Abstractpub_date
1989-12-01 00:00:00pages
532-9issue
4eissn
0019-2805issn
1365-2567journal_volume
68pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Paratyphoid vaccine injected between 4 days and 3 hours before injection of labelled immune complexes (125-I-labelled BGG-anti-BGG), inhibits follicular trapping of these complexes in the mouse spleen. Inhibition is maximal when paratyphoid vaccine is given 1 day before, almost no label being found in the spleen folli...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:Lipoprotein lipase (LPL) is the key enzyme in the metabolism of triglyceride-rich lipoproteins. The patterns of LPL mRNA expression and secretion of the enzyme have not yet been established in natural killer (NK) cells. We show in the present communication that CD3- CD16+ cells (NK cells) transcribe LPL mRNA, express ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:The classical acute phase reactant, C-reactive protein (CRP), appears in markedly elevated concentration in the sera of individuals undergoing reactions of acute inflammation and tissue degradation. We previously demonstrated that like IgG, appropriately purified CRP could be thermally modified (H-CRP) such that it en...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:Secretory component (SC or polymeric immunoglobulin receptor) on mucosal epithelial cells mediates transcytosis of polymeric immunoglobulin into external fluids and functions as a receptor for polymeric immunoglobulin. SC expression in a human colonic adenocarcinoma cell line, HT-29 has been reported to be up-regulate...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00341.x
更新日期：1997-10-01 00:00:00
abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12155
更新日期：2013-12-01 00:00:00
abstract：:N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showe...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:T-cell-mediated immunity to a virulent strain of Plasmodium berghei NK65 (Pb NK65) and to an attenuated derivative (Pb XAT) of the strain were examined in CBA mice by the administration of monoclonal antibodies against T-cell subsets or interferon-gamma (IFN-gamma). The injection of anti-CD8+ or anti-IFN-gamma delayed...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12769
更新日期：2017-10-01 00:00:00
abstract：:Much of the pathology of malaria may be due to the interactions of cytokines, especially tumour necrosis factor (TNF), with various cell types, including endothelial cells, with consequent widespread systemic effects. It has been shown previously that heat-stable exoantigens in the supernatants of blood-stage parasite...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:It is believed that self-reactive forbidden T-cell clones are generated by 'failure' of the pathway of T-cell differentiation in the thymus, if it is disturbed. We examined how such forbidden clones are generated under immunosuppressive conditions. Mice were treated with an injection of deoxyspergualin, FK506, or cycl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00222.x
更新日期：1997-05-01 00:00:00
abstract：:The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03125.x
更新日期：2009-08-01 00:00:00
abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Osteopontin (OPN) is a secreted phosphoprotein found in body fluids (e.g. plasma, urine, milk) and in mineralized tissues. Its expression is increased in many transformed cells and in normal cells exposed to various cytokines. When stimulated with the inflammatory mediators lipopolysaccharide and interferon-gamma, mou...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.d01-691.x
更新日期：1996-08-01 00:00:00
abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00580.x
更新日期：1998-09-01 00:00:00
abstract：:Cutaneous delayed hypersensitivity reactions to collagen in guinea-pigs were partially but specifically suppressed if the animals had been pretreated with collagen and Freund's incomplete adjuvant. Such animals responded normally to skin-reactive factor prepared with ovalbumin. Lymphoid cells from animals with normal ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Variation in the sequence of T-cell epitopes between dengue virus (DENV) serotypes is believed to alter memory T-cell responses during second heterologous infections. We identified a highly conserved, novel, HLA-B57-restricted epitope on the DENV NS1 protein. We predicted higher frequencies of B57-NS1(26-34) -specific...
journal_title：Immunology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/imm.12161
更新日期：2014-01-01 00:00:00
abstract：:2B4 (CD244) is a member of the CD2 subset of the immunoglobulin superfamily and functions as a triggering molecule on natural killer (NK) cells. Previously, we have found that 2B4-mediated activation of NK cells involves complex interactions involving LAT, Ras, Raf, ERK and p38 and that cytolytic function and cytokine...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01662.x
更新日期：2003-07-01 00:00:00
abstract：:Tumour necrosis factor-alpha (TNF-alpha) and cis-urocanic acid (UCA) have recently been implicated in the process by which ultraviolet B radiation (UVB) impairs the induction of contact hypersensitivity when dinitrofluorobenzene (DNFB) is painted on UVB-exposed skin. The evidence supports the hypothesis that UVB radia...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Simultaneous kinetic measurements have been made of basophil degranulation and of histamine release. Both antigen and ionophore A23187 were studied. Cells from the same donor under the same conditions undergo both reactions at a similar rate. Regression analysis indicated a statistically highly significant correlation...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-07-01 00:00:00
abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02262.x
更新日期：2006-01-01 00:00:00
abstract：:Functionally defined mouse Lyt-1 and Lyt-2 cell sets were selected from peripheral lymph nodes by cytotoxic elimination with anti-Lyt monoclonal antibodies. The selected populations were labelled with 51Cr or [3H]-adenosine and traced in syngeneic recipients at 1, 24, 45 and 65 hr after intravenous injection. Recovere...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:An examination was made of the effects of eosinophilia on acute inflammation. Sprague Dawley rats were infected with Trichinella spiralis larvae which resulted in a blood eosinophilia. Groups of rats with the induced eosinophilia, and untreated rats without the eosinophilia, were treated with carrageenan, bradykinin o...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02838.x
更新日期：2008-10-01 00:00:00
abstract：:We explored the mechanisms of class B CpG-oligodeoxynucleotide-induced antitumour effects against weakly immunogenic tumours. Treatment with CpG-oligodeoxynucleotide 1826 (CpG) induced similar antitumour effects in B16 melanoma-bearing immunocompetent C57BL/6 mice and T-cell-deficient severe combined immunodeficient (...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02517.x
更新日期：2007-03-01 00:00:00
abstract：:The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli lipopolysaccharide (LPS) were investigated. Agents formed two broad groups according to the time-dependence of their effects. Class I agents inhibited responses if given at any time over a broad period from ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:Flow cytometric analyses of the surface immunoglobulins of murine memory B cells revealed the existence of populations expressing multiple isotypes, including an IgM+/IgG+ population that could be stimulated in vitro with antigen to secrete both IgM and IgG. Female BALB/c mice were immunized with R-phycoerythrin (RPE)...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
