Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:Murine embryonic stem (ES) cell-derived haematopoietic progenitor cells (HPCs) engraft and populate lymphoid organs. In vivo, HPCs engraft across MHC barriers protecting donor-type allografts from rejection. However, the underlying phenomenon remains elusive. Here, we sought to determine the mechanism by which ES cell...

journal_title：Immunology

authors： Kim EM,Miyake B,Aggarwal M,Voetlause R,Griffith M,Zavazava N

更新日期：2014-07-01 00:00:00

abstract：:The nature of the Fc receptors for IgG subclasses displayed on the epithelium of the small intestine in neonatal rats was examined by comparing results gained from 125I-IgG binding studies using isolated enterocyte brush borders, and from experiments where in vivo transmission from the gut to the bloodstream was quant...

journal_title：Immunology

authors： Peppard JV,Jackson LE,Mackenzie NM

更新日期：1985-09-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:This study investigates the effect of feeding fermented milks with Lactobacillus casei, Lactobacillus acidophilus and a mixture of both micro-organisms on the specific and non-specific host defence mechanisms in Swiss mice. Animals fed with fermented milk for 8 days (100 micrograms/day) showed an increase in both phag...

journal_title：Immunology

authors： Perdigón G,de Macias ME,Alvarez S,Oliver G,de Ruiz Holgado AP

更新日期：1988-01-01 00:00:00

abstract：:Dendritic cells (DC) are the initiators of immune responses and are present in most tissues in vivo. To generate myeloid DC from monocytes (MoDC) in vitro the necessary cytokines are granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). Using degenerated primers delineated from other spec...

journal_title：Immunology

authors： Mauel S,Steinbach F,Ludwig H

更新日期：2006-04-01 00:00:00

abstract：:Experiments were designed to determine the in vivo cell-cycle phase of lymphocytes in secondary lymphoid follicles, and whether B-cell proliferation and apoptosis occur within follicular dendritic cell (FDC)-associated clusters. Using frozen serial sections of human tonsils, lymphoid follicles were stained to reveal h...

journal_title：Immunology

authors： Orui H,Yamakawa M,Imai Y

更新日期：1997-04-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...

journal_title：Immunology

authors： Bathke B,Pätzold J,Kassub R,Giessel R,Lämmermann K,Hinterberger M,Brinkmann K,Chaplin P,Suter M,Hochrein H,Lauterbach H

更新日期：2018-06-01 00:00:00

abstract：:Interleukin-1 (IL-1) is an important mediator of inflammation and has been implicated in several forms of immunopathology. Here we have investigated whether IL-1 plays a role in the enteropathy which occurs during a graft-versus-host reaction (GVHR) in mice. Non-irradiated (CBA x BALB/c) F1 mice with GVHR had increase...

journal_title：Immunology

authors： Mowat AM,Hutton AK,Garside P,Steel M

更新日期：1993-09-01 00:00:00

abstract：:Testing of extracts of Toxoplasma gondii (RH strain) indicated that delayed hypersensitivity as manifested by delayed skin reactions and inhibition of macrophage migration was induced only by those fractions containing RNA. ...

journal_title：Immunology

authors： Lai CH,Tizard IR,Quinn PJ,Ingram DG

更新日期：1975-04-01 00:00:00

abstract：:Nod-like receptors are a family of innate immune receptors that link cytosolic sensing of microbial and danger stimuli to the activation of immune responses. Two Nod-like receptor family members, Nod1 and Nod2, recognize bacterial peptidoglycan and activate immune responses via nuclear factor-κB (NF-κB) and mitogen-ac...

journal_title：Immunology

authors： Jeong YJ,Kang MJ,Lee SJ,Kim CH,Kim JC,Kim TH,Kim DJ,Kim D,Núñez G,Park JH

更新日期：2014-10-01 00:00:00

abstract：:Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...

journal_title：Immunology

authors： Huemer HP,Wang Y,Garred P,Koistinen V,Oppermann S

更新日期：1993-08-01 00:00:00

abstract：:In mice arthritis model induced by anti-type II collagen (CII) antibodies and lipopolysaccharide (LPS), most of cells that infiltrated into the joint space were neutrophils. To investigate the role of neutrophils in the pathogenesis of arthritis, we depleted the neutrophils in vivo by injection of the antibody against...

journal_title：Immunology

authors： Tanaka D,Kagari T,Doi H,Shimozato T

更新日期：2006-10-01 00:00:00

abstract：:Using a cell culture system, age-associated changes in immune activities were investigated in newly developed, short-lived mouse strains. These SAM-P strains of mice (H-2k), which have a remarkably short life span (around 9 months) under conventional breeding conditions, showed an age-associated early decline in sever...

journal_title：Immunology

authors： Hosokawa T,Hosono M,Higuchi K,Aoike A,Kawai K,Takeda T

更新日期：1987-11-01 00:00:00

abstract：:The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...

journal_title：Immunology

authors： Specht Grijp-Glandorf RJ,De Heer E,Dekker-Nooren CC,Daha MR,Van Es LA

更新日期：1990-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells fr...

journal_title：Immunology

authors： Dorner M,Brandt S,Tinguely M,Zucol F,Bourquin JP,Zauner L,Berger C,Bernasconi M,Speck RF,Nadal D

更新日期：2009-12-01 00:00:00

abstract：:The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli lipopolysaccharide (LPS) were investigated. Agents formed two broad groups according to the time-dependence of their effects. Class I agents inhibited responses if given at any time over a broad period from ...

journal_title：Immunology

authors： Berenbaum MC

更新日期：1979-02-01 00:00:00

abstract：:Peritoneal macrophages from CBA mice incubated with recombinant murine tumour necrosis factor (TNF-alpha) are effective in killing the protozoa parasite Leishmania major in vitro. The leishmanicidal activity is directly correlated with the level of nitrite (NO2-) in the culture supernatants. The killing of intracellul...

journal_title：Immunology

authors： Liew FY,Li Y,Millott S

更新日期：1990-12-01 00:00:00

abstract：:The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...

journal_title：Immunology

authors： Hamilton SR,Keren DF,Yardley JH,Brown G

更新日期：1981-03-01 00:00:00

abstract：:The human primary and secondary IgG subclass antibody responses to keyhole limpet haemocyanin (KLH) have been measured by ELISA using IgG subclass-specific monoclonal antibodies. KLH-specific IgG1 and IgG2 antibodies were detected 3 weeks after primary immunization, and IgG1, IgG2 and IgG4 antibodies after secondary i...

journal_title：Immunology

authors： Bird P,Calvert JE,Amlot PL

更新日期：1990-03-01 00:00:00

abstract：:Immunization with intact IgG has allowed the isolation of four hybridomas producing antibodies recognizing epitopes expressed within subpopulations of human kappa light chains unrelated to known polymorphisms (Km) and previously defined V-region subgroups. The V-region-associated epitopes recognized are conformation-d...

journal_title：Immunology

authors： Walker M,Hardie D,Lowe J,Ling NR,De Lange G,Jefferis R

更新日期：1985-06-01 00:00:00

abstract：:Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the ...

journal_title：Immunology

authors： Scinicariello F,Engleman CN,Jayashankar L,McClure HM,Attanasio R

更新日期：2004-01-01 00:00:00

abstract：:The negative role exerted by cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the regulation of T-cell activity, as induced by T-cell receptor (TCR)/CD3 and CD28 costimulation, has been widely described. In the present work we investigated the role of CTLA-4 in the control of cell activation, as induced by cost...

journal_title：Immunology

authors： Gatta L,Calviello G,Di Nicuolo F,Pace L,Ubaldi V,Doria G,Pioli C

更新日期：2002-10-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...

journal_title：Immunology

authors： Ricciardelli I,Lindley KJ,Londei M,Quaratino S

更新日期：2008-10-01 00:00:00

abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...

journal_title：Immunology

authors： Kasahara T,Shioiri-Nakano K,Sugiura A

更新日期：1977-06-01 00:00:00

abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...

journal_title：Immunology

authors： Bramwell VW,Eyles JE,Somavarapu S,Alpar HO

更新日期：2002-07-01 00:00:00

abstract：:The objective of the present study was to examine and to compare the impact of severe protein malnutrition during development, adulthood and ageing on secretory immune expression in the eye, mouth and small intestine. In addition, we sought to determine whether potential abrogation of mucosal immunity by protein depri...

journal_title：Immunology

authors： Sullivan DA,Vaerman JP,Soo C

更新日期：1993-02-01 00:00:00