Abstract：
:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaque forming cells (V-PFC) were observed not only during the activation of T lymphocytes with Con A, but also, though to a lesser extent, during the activation with lipopolysaccharide (LPS) of non-T lymphocyte preparations of nude spleen from which theta-positive lymphocytes and macrophages were completely depleted. The latter observation was further confirmed by the VPA on the populations enriched in LPS-activated non-T lymphocytes fractionated by the unit gravity sedimentation method. Fast sedimenting cells were found to be more active in DNA synthesis and contained more infective centres after infection than those sedimenting slowly and original unfractionated cells. Both the capacity for DNA synthesis and virus-replication were considered to be general properties accompanying lymphocyte activation.
journal_name
Immunologyjournal_title
Immunologyauthors
Kasahara T,Shioiri-Nakano K,Sugiura Asubject
Has Abstractpub_date
1977-06-01 00:00:00pages
875-83issue
6eissn
0019-2805issn
1365-2567journal_volume
32pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:The 'binding' of IgE to particulate preparations derived from sonicated purified rat mast cells was measured by the blocking of PCA titrations of the supernatant solutions from incubations with such preparations. It was found that the PCA blocking reaction was inhibited by the addition of calcium ion to the incubation...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.d01-2281.x
更新日期：1997-08-01 00:00:00
abstract：:Effect of macrophage culture fluid (MF) on thymic independent (TI) antibody responses was examined. MF potentiated antibody responses of spleen cells to dinitrophenyl (DNP)-Ficoll and DNP-liposome, TI-2 antigens, but not to trinitrophenyl (TNP)-BA and TNP-LPS, TI-1 antigens. The enhancing effect of MF on the anti-DNP-...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single injection of antigen was found to increase during the first 6 weeks of life. The responses of 1- and 2-week-old animals als...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Drug abuse is a global problem of considerable concern to health. One such health concern stems from the fact that many drugs of abuse have immunosuppressive actions and consequently have the potential to increase susceptibility to infectious disease. This article is focused on the impact of the amphetamine derivative...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.0019-2805.2004.01847.x
更新日期：2004-04-01 00:00:00
abstract：:Recent studies employing reverse transription-polymerase chain reaction (RT-PCR) have demonstrated the intrathymic presence of mRNA for various autoantigens, including thyroglobulin (Tg). Deliberations on the mechanisms of central tolerance usually assume that this approach detects intact mRNA transcripts that can be ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02119.x
更新日期：2005-05-01 00:00:00
abstract：:The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03102.x
更新日期：2009-09-01 00:00:00
abstract：:We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure popul...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:Various methods for measuring monocyte numbers and function in human blood are compared. The assays used were: phagocytosis of antibody-sensitized sheep red cells; staining for diffuse non-specific esterase activity; capacity to adhere to polystyrene and ability to lyse human A1 red cells sensitized with allogeneic an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
abstract：:To date, the most potent mucosal vaccine adjuvants to be identified have been bacterial toxins. The present data demonstrate that the type 2 ribosome-inactivating protein (type 2 RIP), mistletoe lectin I (ML-I) is a strong mucosal adjuvant of plant origin. A number of plant lectins were investigated as intranasal (i.n...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01157.x
更新日期：2001-01-01 00:00:00
abstract：:The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03125.x
更新日期：2009-08-01 00:00:00
abstract：:A non-specific suppressor factor, owl monkey suppressor factor, OMSF, from leukaemic owl monkey peripheral T lymphocytes has been isolated and characterized. OMSF is a glycoprotein of a molecular weight of 66,000 which can be produced from purified owl monkey enhancing factor, OMEF, by both Tris buffer dialysis and by...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and m...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:Human polymorphonuclear granulocytes (PMN) generate the inflammatory mediator leukotriene B4 (LTB4) as a response to cell activation. In addition, PMN inactivate LTB4 by omega-oxidation resulting in the formation of 20-OH- and 20-COOH-LTB4. The transport of exogenous LTB4 to the metabolizing enzymes is mediated via hi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12023
更新日期：2013-02-01 00:00:00
abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03212.x
更新日期：2010-05-01 00:00:00
abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：:Different genetic mutations have been described in complement component C7 deficiency, a molecular defect clinically associated with an increased susceptibility to neisserial recurrent infections. In this work we report the genetic basis of C7 deficiency in two different Spanish families (family 1 and family 2). In fa...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2004.01997.x
更新日期：2004-12-01 00:00:00
abstract：:Mouse spleen cells from animals immunized with bovine peripheral blood lymphocytes were fused to X63 . Ag8 myeloma cells and the activity of one of the resulting myeloma hybrids was characterized. The product of this clone (B5/4.1.4) binds to pentameric bovine IgM isolated from serum but not to serum IgG1 or IgG2. Thi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-07-01 00:00:00
abstract：:Natural killer (NK) cells have a specialized function in peripheral organs, which is determined by the organ-specific niches. We have attempted to explore whether lung NK cells display a particular phenotype according to their function in the unique pulmonary environment in health or during respiratory infection in mi...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2012.03607.x
更新日期：2012-09-01 00:00:00
abstract：:The role of the mouse homocytotropic antibodies in passive cutaneous anaphylaxis reaction was investigated. One class of antibody was heat stable, detected at 2 h but not at 48 h after passive transfer, and belonged to a sublcass of mouse IgG. The other was heat labile, detected at 2 h and 48 h after passive transfer,...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB-DM, TB or diabetes mellitus (DM), and in healthy contro...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.13023
更新日期：2019-03-01 00:00:00
abstract：:Interleukin-13 (IL-13) is a cytokine which significantly enhances the proliferation and differentiation of B lymphocytes. We therefore evaluated its role in the formation of a humoral immune response in vivo. Upon oral immunization with the B subunit of Escherichia coli heat-labile enterotoxin (LT-B), rapid up-regulat...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1996.502574.x
更新日期：1996-04-01 00:00:00
abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/imm.12045
更新日期：2013-05-01 00:00:00
abstract：:Polystyrene surfaces coated with proteins at alkaline pH were found to be useful to investigate the stimulation of neutrophils independently of phagocytosis. Human neutrophils, when exposed to appropriate stimuli, release superoxide anion (O2-). We have measured superoxide dismutase-inhibitable cytochrome c reduction ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:We have studied the adhesion of human CD4+ lymphocytes to cultured human retinal vascular endothelial cells (EC) and human retinal pigment epithelial cells (RPE), both of which comprise the cellular components of the blood-retina barrier. We have observed differences in the lymphocyte-RPE and the lymphocyte-EC interac...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:CD27 is a T-cell surface antigen expressed on the majority of peripheral T cells and belongs to a newly defined receptor family including the low-affinity nerve growth factor receptor, tumour necrosis factor (TNF) receptors, the B-cell activation antigen CD40, and the Fas antigen. Although the function of CD27 has not...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:The numbers of murine hepatocytes and Kupffer cells with receptors for human polymeric (pIgA) or monomeric IgA (mIgA) were determined by rosette formation with immunobeads coated with human pIgA or mIgA. About 63% of hepatocytes were found to express receptors for pIgA. Receptors for mIgA were also found in a signific...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Donor T cells are crucial for target organ injury in graft-versus-host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent-into-F1 model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01240.x
更新日期：2001-07-01 00:00:00
abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12157
更新日期：2013-12-01 00:00:00
