Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.

abstract：:Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer (NK)-cell-mediated killing. This has been explained by either (1) the target interference model, or (2) the effector inhibition mod...

journal_title：Immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-09-01 00:00:00

abstract：:The epigenetic regulation of transcription factor genes is critical for T-cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is requi...

journal_title：Immunology

authors： Kehrmann J,Tatura R,Zeschnigk M,Probst-Kepper M,Geffers R,Steinmann J,Buer J

更新日期：2014-07-01 00:00:00

abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...

journal_title：Immunology

authors： Woo P,Lachmann PJ

更新日期：1981-11-01 00:00:00

abstract：:We produced three murine monoclonal antibodies (mAb) directed against the human T-cell differentiation antigen CD2 (formerly T11) and analysed their epitope specificity by E-rosette inhibition, cross-blocking and proliferation-induction experiments. When added together, two mAb (both IgG1 kappa) were able to induce pr...

journal_title：Immunology

authors： van Lier R,Bloemena E,Brouwer M,Van Heijst J,Weinreich S,Aarden L

更新日期：1989-07-01 00:00:00

abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...

journal_title：Immunology

authors： Milićević NM,Nohroudi K,Milićević Z,Hedrich HJ,Westermann J

更新日期：2005-11-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role in SLE pathogenesis. One proposed ...

journal_title：Immunology

authors： Lee J,Shin EK,Lee SY,Her YM,Park MK,Kwok SK,Ju JH,Park KS,Kim HY,Cho ML,Park SH

更新日期：2014-08-01 00:00:00

abstract：:The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...

journal_title：Immunology

authors： Daus H,Hammer HJ,Rajki K,Mauch H

更新日期：1984-08-01 00:00:00

abstract：:alpha 1-Acid glycoprotein (AG), a serum component elevated during acute inflammation, has been implicated in the suppression of various immunological responses. Pretreatment of lymphoid cells with AG at a concentration commonly found in patients with acute inflammation results in the inhibition of mitogen induced lymp...

journal_title：Immunology

authors： Cheresh DA,Haynes DH,Distasio JA

更新日期：1984-03-01 00:00:00

abstract：:Chlamydia trachomatis is a major cause of sexually transmitted disease, infertility and reactive arthritis in the Western world, and of trachoma in the developing world. There is evidence that the chronic inflammatory reaction seen in diseases associated with chlamydiae represents a delayed-type hypersensitivity respo...

journal_title：Immunology

authors： Hassell AB,Reynolds DJ,Deacon M,Gaston JS,Pearce JH

更新日期：1993-08-01 00:00:00

abstract：:The humoral and mucosal immune responses to oral immunization with xenogeneic antibodies were studied using an animal model in which female rabbits were fed daily doses of the MOPC-315 murine IgA antibody, and were mated during the course of the feeding programme. Serum and colostrum samples were assayed for the prese...

journal_title：Immunology

authors： Collins AM,Roberton DM,Hosking CS,Flannery GR

更新日期：1991-08-01 00:00:00

abstract：:The properties of IgA and IgG anti-gliadin antibodies from the serum of patients with coeliac disease have been compared. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions. Their specificity was confirmed by immunoblotting. Heat-treated sera containing IgA antibodies s...

journal_title：Immunology

authors： Stewart WW,Kerr MA

更新日期：1991-08-01 00:00:00

abstract：:Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...

journal_title：Immunology

authors： Lynch NR,Prin J,Salomon JC

更新日期：1977-01-01 00:00:00

abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...

journal_title：Immunology

authors： Kappel M,Diamant M,Hansen MB,Klokker M,Pedersen BK

更新日期：1991-07-01 00:00:00

abstract：:A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...

journal_title：Immunology

authors： Rikiishi H,Okamoto S,Sugawara S,Tamura K,Liu ZX,Kumagai K

更新日期：1997-07-01 00:00:00

abstract：:We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the Ly49A receptor. Affinity chromatography using peptides corresponding to the N-terminal 18 amino acids of Ly49A allowed the recovery of a number of proteins that bound preferentially to the ty...

journal_title：Immunology

authors： Daws MR,Eriksson M,Oberg L,Ullén A,Sentman CL

更新日期：1999-08-01 00:00:00

abstract：:Docosahexaenoic (22:6 n-3) and eicosapentaenoic acid (20:5 n-3) stimulated the oxygen-dependent respiratory burst in intact neutrophils in a dose-dependent manner as measured by either superoxide dismutase (SOD)-inhibitable cytochrome c reduction and lucigenin-dependent chemiluminescence. A number of longer chain hexa...

journal_title：Immunology

authors： Poulos A,Robinson BS,Ferrante A,Harvey DP,Hardy SJ,Murray AW

更新日期：1991-05-01 00:00:00

abstract：:The process by which naive T cells become activated, differentiate into effector cells and ultimately generate long-lived memory cells is dependent upon a number of factors, including the costimulatory signals received by the T cell. To best understand the multiple events involved, it is important to understand the po...

journal_title：Immunology

authors： Kohlmeier JE,Chan MA,Benedict SH

更新日期：2006-08-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...

journal_title：Immunology

authors： Miyata H,Himeno K,Miake S,Nomoto K

更新日期：1981-10-01 00:00:00

abstract：:Human neutrophils express Toll-like receptor 4 (TLR4) at low levels, and the role of this receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation of these cells to enable the study of the role of proteins such as TLR4 in their function is challenging. Here, we show that primary ...

journal_title：Immunology

authors： Dick EP,Prince LR,Prestwich EC,Renshaw SA,Whyte MK,Sabroe I

更新日期：2009-06-01 00:00:00

abstract：:Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). We have investigated the effect of gangliosides on the interaction of IL-2 wit...

journal_title：Immunology

authors： Chu JW,Sharom FJ

更新日期：1993-05-01 00:00:00

abstract：:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed ...

journal_title：Immunology

authors： Hübner MP,Stocker JT,Mitre E

更新日期：2009-08-01 00:00:00

abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...

journal_title：Immunology

authors： Yoneno K,Hisamatsu T,Shimamura K,Kamada N,Ichikawa R,Kitazume MT,Mori M,Uo M,Namikawa Y,Matsuoka K,Sato T,Koganei K,Sugita A,Kanai T,Hibi T

更新日期：2013-05-01 00:00:00

abstract：:Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibo...

journal_title：Immunology

authors： Kummu O,Turunen SP,Prus P,Lehtimäki J,Veneskoski M,Wang C,Hörkkö S

更新日期：2014-03-01 00:00:00

abstract：:We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...

journal_title：Immunology

authors： Chen XJ,Lycke N,Enerbäck L

更新日期：1999-04-01 00:00:00

abstract：:The in vitro treatment with Fusarenon-X, a mycotoxin produced by Fusarium nivale Fn 2B, depressed the mitogenic responses of mouse lymphocytes to the T-cell mitogens, phytohaemagglutinin (PHA) and concanavalin A (Con A), but to a lesser extent to B-cell mitogen, a bacterial lypopolysaccharide (LPS). The in vitro treat...

journal_title：Immunology

authors： Masuda E,Takemoto T,Tatsuno T,Obara T

更新日期：1982-04-01 00:00:00

abstract：:Detection of immune complexes by inhibition of antibody-dependent cellular cytotoxicity (ADCC) is based on the principle that soluble complexes can compete with target cell-bound antibody for receptors (FcR) on cytotoxic lymphocytes. The objective of this study was to define a cytotoxicity system for the determination...

journal_title：Immunology

authors： Howat JM,Moore M,Hilton AM,Kimber I

更新日期：1979-06-01 00:00:00

abstract：:The synthetic antigen denoted P2-A--L, comprising the fragment P2 of the coat protein of MS-2 coliphage attached to multichain poly-DL-alanine, served for the immunization of guinea-pigs. Immunization was carried out either in phosphate buffered saline (PBS) or in Freund's incomplete adjuvant (FIA) in the presence or ...

journal_title：Immunology

authors： Langbeheim H,Arnon R,Sela M

更新日期：1978-10-01 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:We previously identified a cis-acting element within the 3' untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequences of the three binding sites with re...

journal_title：Immunology

authors： Laughlin J,Oghlidos S,Porter JF,Matus-Nicodemos R,Sinquett FL,Marcelli V,Covey LR

更新日期：2008-07-01 00:00:00