Abstract:
:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed diabetes by 25 weeks of age, no L. sigmodontis-infected mice developed disease. Although all mice had evidence of ongoing islet cell inflammation by histology, L. sigmodontis-infected mice had greater numbers of total islets and non-infiltrated islets than control mice. Protection against diabetes was associated with a T helper type 2 (Th2) shift, as interleukin-4 (IL-4) and IL-5 release from alpha-CD3/alpha-CD28-stimulated splenocytes was greater in L. sigmodontis-infected mice than in uninfected mice. Increased circulating levels of insulin-specific immunoglobulin G1, showed that this Th2 shift occurs in response to one of the main autoantigens in diabetes. Multicolour flow cytometry studies demonstrated that protection against diabetes in L. sigmodontis-infected NOD mice was associated with significantly increased numbers of splenic CD4(+) CD25(+) FoxP3(+) regulatory T cells. Interestingly, injection of crude worm antigen into NOD mice also resulted in protection against type 1 diabetes, though to a lesser degree than infection with live L. sigmodontis worms. In conclusion, these studies demonstrate that filarial worms can protect against the onset of type 1 diabetes in NOD mice. This protection is associated with a Th2 shift, as demonstrated by cytokine and antibody production, and with an increase in CD4(+) CD25(+) FoxP3(+) regulatory T cells.
journal_name
Immunologyjournal_title
Immunologyauthors
Hübner MP,Stocker JT,Mitre Edoi
10.1111/j.1365-2567.2008.02958.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
512-22issue
4eissn
0019-2805issn
1365-2567pii
IMM2958journal_volume
127pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract::Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00997.x
更新日期:2000-05-01 00:00:00
abstract::The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2008.02901.x
更新日期:2009-03-01 00:00:00
abstract::From our experiments and those of others in which cells were cultured at a density of 100,000 cells per well, it has been suggested that autoantibody production against mouse bromelain-treated erythrocytes (mouse brom-RBC) was independent of T cells, and further, was enhanced by the removal of T cells from responsive ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::The expression of adhesion molecules on vascular endothelial cells determines the pattern of migration and extravasation of leucocytes in inflammation and immunity. Here we show that costimulation with CD40 ligand (CD40L) and interleukin (IL)-4 (or IL-13) gives rise to a unique pattern of adhesion molecule expression ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00061.x
更新日期:2000-08-01 00:00:00
abstract::Regulatory T (Treg) cells act to suppress activation of the immune system and thereby maintain immunological homeostasis and tolerance to self-antigens. The frequency and suppressing activity of Treg cells in general are high in different malignancies. We wanted to identify the role and regulation of CD4(+) CD25(+) ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12237
更新日期:2014-05-01 00:00:00
abstract::To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynuc...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2001.01222.x
更新日期:2001-06-01 00:00:00
abstract::Lymphoid cells in decidualized uterine endometrium in early human pregnancy may be essential for successful implantation and placentation. Endometrial granulocytes are prominent in early pregnancy decidua and express some T-cell associated surface antigens (CD2+, CD7+), but little is known of their function. We report...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12614
更新日期:2016-08-01 00:00:00
abstract::The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Type A chrysotile fibres (white asbestos) were tested in vitro for activation of the complement system. Fibres were incubated in normal human serum (NHS), factor B-depleted human serum, and normal and C4-deficient guinea-pig sera; the supernates were assayed for the remaining complement activity. Activation of the alt...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::We have previously reported that the immunization of BALB/c mice with MOPC-104E myeloma protein (M104E) induced idiotype-specific Ly 1-negative B lymphocytes that had an ability to enhance idiotype-positive anti-dextran antibody production. It was also shown that the cell interaction between idiotypic and anti-idiotyp...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrop...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2010.03274.x
更新日期:2010-09-01 00:00:00
abstract::NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2567.2009.03147.x
更新日期:2009-09-01 00:00:00
abstract::Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-spe...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2003.01769.x
更新日期:2003-12-01 00:00:00
abstract::The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes and some peripheral-blood T cells are negative. T-80- thymocytes reside in the m...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12155
更新日期:2013-12-01 00:00:00
abstract::Staphylococcal enterotoxins (SE) are potent T-lymphocyte activators that stimulate T cells by directly cross-linking HLA-DR molecules on antigen-presenting cells with the V beta gene products of the T-cell receptor. The different SE activate all T cells expressing a given V beta, and, therefore, have been termed 'supe...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::Regeneration of the thymus was studied in rats that were treated with a single oral dose of the organotin compound di-n-butyltin dichloride (DBTC). After an initial maximum depletion of cortical BrdU+ thymocytes on day 2 after treatment, repopulation appeared to start on day 3 as indicated by an increased number of Br...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant ce...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::Immunohistochemical analysis of frozen sections of rat lung tissue identified a widely distributed population of highly pleiomorphic Ia+ cells in alveolar septal walls, which are negative for the pan-macrophage marker ED4 and the related markers ED1, ED2 and ED9. Semi-purified dendritic cells (DC) prepared from lungs ...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Expression of the lymph node homing and CC-chemokine receptor 7 (CCR7), with L-selectin (CD62L), has been shown to divide human memory T cells into two functionally distinct subsets. We generated a polyclonal antibody against murine CCR7 and used this antibody to study CCR7 expression on murine T-cell subsets. Using f...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2003.01727.x
更新日期:2003-10-01 00:00:00
abstract::Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.1997.00350.x
更新日期:1997-03-01 00:00:00
abstract::Complement activation within lymph nodes has been shown to alter lymphocyte traffic through the node. Challenge of cannulated sheep lymph nodes with either immune complexes or complement activators was found to initiate the phenomenon of cell shutdown associated with antigenic challenge of lymph nodes in primed animal...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::Cells of the female reproductive tract (FRT) can present antigen to naive and memory T cells. However, the effects of oestrogen, known to modulate immune responses, on antigen presentation in the FRT remain undefined. In the present study, DO11.10 T-cell antigen receptor transgenic mice specific for the class II MHC-r...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2011.03512.x
更新日期:2012-01-01 00:00:00
abstract::We studied proliferative responses of bovine T lymphocytes to foot-and-mouth disease virus (FMDV) serotypes A, O and C as well as to three peptides including the two major B-cell epitopes of FMDV (VP1[141-156] and VP1[200-213]). Peripheral blood mononuclear cells (PBMC) from cattle previously vaccinated with monovalen...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...
journal_title:Immunology
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::LacZ (Gal)-reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal-expressing syngeneic tumour cells (ESbL-Gal) in order to study tumour-protective T-cell memory. This transfer prevented tumour outgrowth in recipients and resulted in the persistence of a high frequency of Gal-specific CD8(+)...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2567.2005.02163.x
更新日期:2005-07-01 00:00:00
abstract::We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2567.2000.00107.x
更新日期:2000-10-01 00:00:00