Abstract：
:Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-specific CD8+ T-cell responses in a cohort of HCV-infected individuals with or without Schistosoma mansoni co-infection from Egypt. We observed a significantly decreased CD27- CD28- (late differentiated) memory T-cell population in the HCV co-infected individuals compared to those with HCV infection alone. In contrast, there was no significant difference in the CD27+ CD28+ (early differentiated) memory T cells between the two groups. Analysis of human cytomegalovirus-specific CD8+ T-cell responses in the same individuals failed to reveal a similar pattern of altered memory T-cell differentiation. Thus, S. mansoni co-infection targets a specific subset of memory CD8+ T cells in HCV infection.
journal_name
Immunologyjournal_title
Immunologyauthors
Elrefaei M,El-Sheikh N,Kamal K,Cao Hdoi
10.1111/j.1365-2567.2003.01769.xkeywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
513-8issue
4eissn
0019-2805issn
1365-2567pii
1769journal_volume
110pub_type
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