Abstract：
:Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to specific minor antigens. This report demonstrates that the activity of such antigen-specific Ts cells in four different strain combinations involving two haplotypes is blocked by anti-I-E antibody. The proliferative helper T cells (Th) in the same strain combinations are restricted to I-A molecules. Whether our results reflect a more general bias of suppressor T cells to be restricted to I-E molecules is discussed.
journal_name
Immunologyjournal_title
Immunologyauthors
Nanda NKsubject
Has Abstractpub_date
1989-10-01 00:00:00pages
163-8issue
2eissn
0019-2805issn
1365-2567journal_volume
68pub_type
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