Abstract：
:The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus (SpA) appeared not to be controlled by MHC antigens. The production of IFN alpha, however, was influenced by the HLA type of the donor. Low responsiveness of PBL to inducers of IFN alpha (influenza virus, Molt 4 cells) was associated with HLA-DR 2. Implications of these observations for studies of IFN production and natural killer (NK) cell activity are discussed.
journal_name
Immunologyjournal_title
Immunologyauthors
Abb J,Zander H,Abb H,Albert E,Deinhardt Fsubject
Has Abstractpub_date
1983-06-01 00:00:00pages
239-44issue
2eissn
0019-2805issn
1365-2567journal_volume
49pub_type
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