Abstract:
:Mutation of the interleukin-2 (IL-2) receptor gamma chain, which also serves as a component of the receptor complexes for IL-4, 7, 9 and 15, results in severe immune deficiency. We hypothesized that the immunological immaturity of healthy neonates might be associated with low levels of expression of this receptor molecule. Using monoclonal antibody and a highly sensitive immunofluorescence method, we showed that IL-2 receptor gamma chain is expressed at significantly lower levels on cord blood cells compared with adult cells. IL-2-dependent T-cell activation in vitro was reduced in cord blood cells compared with adult cells, but B-cell responses to IL-4 were not obviously impaired. The lower level of expression of the gamma chain and some other cytokine receptor chains may contribute to the immunological immaturity of the newborn, by selectively depressing particular immunological mechanisms.
journal_name
Immunologyjournal_title
Immunologyauthors
Zola H,Fusco M,Weedon H,Macardle PJ,Ridings J,Roberton DMsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
86-91issue
1eissn
0019-2805issn
1365-2567journal_volume
87pub_type
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