Establishment of functional T cells in SCID mice does not lead to termination of pregnancy.

Abstract:

:Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.

journal_name

Immunology

journal_title

Immunology

authors

Hetherington CM,Dresser DW

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

449-53

issue

3

eissn

0019-2805

issn

1365-2567

journal_volume

71

pub_type

杂志文章