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Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.

Abstract：

:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but can induce lethal T helper type 1-driven inflammation. In contrast, memory CD4 T cells exhibit a biased proliferation of T follicular helper cell subsets and were able to improve adaptive immune responses in the context of minimal tissue damage. Our analyses revealed that type I interferon regulates the expansion of primary CD4 T cells, but does not seem to play a critical role in regulating the expansion of secondary CD4 T cells. Strikingly, blockade of type I interferon abrogated lethal inflammation by primary CD4 T cells following viral infection, despite that this treatment increased the numbers of primary CD4 T-cell responses. Altogether, these data demonstrate important aspects of how primary and secondary CD4 T cells are regulated in vivo, and how they contribute to immune protection and immunopathology. These findings are important for rational vaccine design and for improving adoptive T-cell therapies against persistent antigens.

journal_name

Immunology

journal_title

Immunology

authors

Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

doi

10.1111/imm.12771

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

328-343

issue

2

eissn

0019-2805

issn

1365-2567

journal_volume

152

pub_type

杂志文章

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