The effect of sera from patients with connective tissue diseases on red cell binding and phagocytosis by monocytes.

Abstract:

:The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhanced. Some rheumatoid sera and rheumatoid joint fluids inhibited uptake whereas sera from juvenile rheumatoid patients did not.

journal_name

Immunology

journal_title

Immunology

authors

Temple A,Loewi G

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

109-14

issue

1

eissn

0019-2805

issn

1365-2567

journal_volume

33

pub_type

杂志文章
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    abstract::The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

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    doi:10.1111/j.1365-2567.2012.03587.x

    authors: Browne EP

    更新日期:2012-08-01 00:00:00

  • Interactions of chrysotile asbestos fibres with the complement system.

    abstract::Type A chrysotile fibres (white asbestos) were tested in vitro for activation of the complement system. Fibres were incubated in normal human serum (NHS), factor B-depleted human serum, and normal and C4-deficient guinea-pig sera; the supernates were assayed for the remaining complement activity. Activation of the alt...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Saint-Remy JM,Cole P

    更新日期:1980-10-01 00:00:00

  • Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.

    abstract::Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from M...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2007.02574.x

    authors: Sugata Y,Okano M,Fujiwara T,Matsumoto R,Hattori H,Yamamoto M,Nishibori M,Nishizaki K

    更新日期:2007-06-01 00:00:00

  • Primary cytotoxic T-cell responses to bovine respiratory syncytial virus in calves.

    abstract::Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1996.d01-667.x

    authors: Gaddum RM,Cook RS,Thomas LH,Taylor G

    更新日期:1996-07-01 00:00:00

  • The bovine autologous Theileria mixed leucocyte reaction: influence of monocytes and phenotype of the parasitized stimulator cell on proliferation and parasite specificity.

    abstract::In the autologous Theileria mixed leucocyte reaction (MLR), irradiated Theileria parva-infected cells induce proliferative responses in autologous peripheral blood mononuclear leucocytes (PBM), irrespective of the immune status of the donor animal. In this paper we have analysed the cellular basis of this response in ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Goddeeris BM,Morrison WI

    更新日期:1987-01-01 00:00:00

  • Autologous killing by a population of intermediate T-cell receptor cells and its NK1.1+ and NK1.1- subsets, using Fas ligand/Fas molecules.

    abstract::Self-reactive clones, estimated by anti-V beta monoclonal antibodies (mAb) in conjunction with the Mls system, are confined to a population of intermediate (int) T-cell receptor (TCR) (or CD3) cells (i.e. TCRint cells), but are not found among TCRhigh cells. The next questions to be answered are whether autologous kil...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1997.00240.x

    authors: Moroda T,Iiai T,Suzuki S,Tsukahara A,Tada T,Nose M,Hatakeyama K,Seki S,Takeda K,Watanabe H,Abo T

    更新日期:1997-06-01 00:00:00

  • Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.

    abstract::The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2008.02838.x

    authors: Roche M,Kelly JP,O'Driscoll M,Finn DP

    更新日期:2008-10-01 00:00:00

  • Suppression of tuberculin skin reactivity by prior tuberculin skin testing.

    abstract::In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests s...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Thestrup-Pedersen K

    更新日期:1975-02-01 00:00:00

  • Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins.

    abstract::Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been expose...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/imm.12709

    authors: Nithichanon A,Gourlay LJ,Bancroft GJ,Ato M,Takahashi Y,Lertmemongkolchai G

    更新日期:2017-05-01 00:00:00

  • Expression of rat CD59: functional analysis confirms lack of species selectivity and reveals that glycosylation is not required for function.

    abstract::This study reports the expression and functional characterization of the rat analogue of the human complement regulatory molecule CD59. We here describe the expression in chinese hamster ovary (CHO) cells of rat CD59 and a modified rat CD59 in which an N-glycosylation site at Asn-16 has been deleted by point mutation....

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1997.00200.x

    authors: Rushmere NK,Tomlinson S,Morgan BP

    更新日期:1997-04-01 00:00:00

  • Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.

    abstract::Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates the management of this pathological condition. An animal model of AD-like pruritus would contribute to a better understanding of AD and could lead to the development of safe and effective antipruritic agents. DS non-hair (DS-Nh) mi...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2006.02365.x

    authors: Yoshioka T,Hikita I,Asakawa M,Hirasawa T,Deguchi M,Matsutani T,Oku H,Horikawa T,Arimura A

    更新日期:2006-07-01 00:00:00

  • Characterization of E-selectin-binding epitopes expressed by skin-homing T cells.

    abstract::The glycoprotein counter-receptors for E-selectin borne on skin-homing T cells are poorly defined. In this study we have used flow cytometry to investigate the surface expression of potential carbohydrate ligands for E-selectin on HUT78, a skin-homing cutaneous T-cell lymphoma. These cells possessed high surface expre...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.1998.00551.x

    authors: Priest R,Bird MI,Malhotra R

    更新日期:1998-08-01 00:00:00

  • Influence of pathological progression on the balance between cellular and humoral immune responses in bovine tuberculosis.

    abstract::Studies of tuberculosis have suggested a shift in dominance from a T helper type 1 (Th1) towards a Th2 immune response that is associated with suppressed cell-mediated immune (CMI) responses and increased humoral responses as the disease progresses. In this study a natural host disease model was used to investigate th...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2004.02003.x

    authors: Welsh MD,Cunningham RT,Corbett DM,Girvin RM,McNair J,Skuce RA,Bryson DG,Pollock JM

    更新日期:2005-01-01 00:00:00

  • Differences in cytokine synthesis by the sub-populations of dendritic cells from afferent lymph.

    abstract::Two phenotypically distinct subpopulations of dendritic cells (SIRPalpha+ CC81Ag- DC and SIRPalpha- CC81Ag+ DC) have previously been identified in bovine afferent lymph which show functional differences when assayed in vitro. The purpose of this study was to investigate whether differences in cytokine production betwe...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2003.01712.x

    authors: Stephens SA,Brownlie J,Charleston B,Howard CJ

    更新日期:2003-09-01 00:00:00

  • CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.

    abstract::CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2006.02363.x

    authors: Piercy J,Petrova S,Tchilian EZ,Beverley PC

    更新日期:2006-06-01 00:00:00

  • Human secretory immunoglobulin M. An immunochemical and immunohistochemical study.

    abstract::IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Brandtzaeg P

    更新日期:1975-09-01 00:00:00

  • Neonatal thymus grafts. I. Studies on the regulation of the level of circulating thymic factor (FTS).

    abstract::The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Tubiana N,Dardenne M

    更新日期:1979-02-01 00:00:00

  • No impairment of local intestinal immune response to keyhole limpet haemocyanin in the absence of Peyer's patches.

    abstract::The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Hamilton SR,Keren DF,Yardley JH,Brown G

    更新日期:1981-03-01 00:00:00

  • The genetic control of antibody affinity in mice.

    abstract::Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Katz FE,Steward MW

    更新日期:1975-09-01 00:00:00

  • Immune response mediated by liposome-associated protein antigens. I. Potentiation of the plaque-forming cell response.

    abstract::Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Shek PN,Sabiston BH

    更新日期:1982-02-01 00:00:00

  • Wheat germ agglutinin potentiates uptake of bacteria by murine peritoneal macrophages.

    abstract::Exposure of thioglycollate-elicited murine peritoneal macrophages to wheat germ agglutinin (WGA) increased markedly the uptake of six different bacteria, which have surface receptors for the lectin. Uptake of Staphylococcus aureus H was higher by 3-5-fold, of S. aureus 52A2 by 1.8-fold, of S. aureus 52A5 by 1.7-fold, ...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Gallily R,Vray B,Stain I,Sharon N

    更新日期:1984-08-01 00:00:00

  • Translating innate response into long-lasting antibody response by the intrinsic antigen-adjuvant properties of papaya mosaic virus.

    abstract::Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2567.2007.02753.x

    authors: Acosta-Ramírez E,Pérez-Flores R,Majeau N,Pastelin-Palacios R,Gil-Cruz C,Ramírez-Saldaña M,Manjarrez-Orduño N,Cervantes-Barragán L,Santos-Argumedo L,Flores-Romo L,Becker I,Isibasi A,Leclerc D,López-Macías C

    更新日期:2008-06-01 00:00:00

  • Inhibition of cell-mediated cytotoxicity by 2-cyclohexene-1-one: evidence for a role for glutathione and/or glutathione-protein interactions in cytolysis.

    abstract::In order to explore the role of glutathione in cell-mediated cytotoxicity, we have examined the effect of the sulphydryl-reactive and glutathione-depleting agent 2-cyclohexene-1-one on antibody-dependent cellular cytotoxicity, spontaneous cell-mediated cytotoxicity, and cell-mediated lympholysis by human peripheral bl...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: MacDermott RP,Bertovich MJ,Bragdon MJ,Nash GS,Leusch MS,Wedner HJ

    更新日期:1986-04-01 00:00:00

  • Passive cutaneous anaphylaxis and vasoactive amine challenge in nude (nu/nu) mice. A comparison with nu/+, axenic and young normal animals.

    abstract::Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Lynch NR,Prin J,Salomon JC

    更新日期:1977-01-01 00:00:00

  • Lipopolysaccharide and phorbol 12-myristate 13-acetate both impair monocyte differentiation, relating cellular function to virus susceptibility.

    abstract::Both lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) impeded monocyte to macrophage differentiation with respect to typical phenotypic modulation and certain phagocyte-related processes. The down-regulation of the porcine monocyte marker SWC1, and up-regulation of the SWC9 macrophage marker were ret...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2001.01266.x

    authors: Basta S,Knoetig S,Summerfield A,McCullough KC

    更新日期:2001-08-01 00:00:00

  • Carrier-induced suppression of the antibody response to a 'self' hapten.

    abstract::Immunization of male rats and monkeys with gonadotropin-releasing hormone (GnRH) conjugated to a carrier results in a dramatic atrophy of the prostate. GnRH, linked to either diphtheria toxoid or tetanus toxoid as carrier, is now being evaluated for its use in the immunotherapy of hormone-dependent prostate enlargemen...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Sad S,Gupta HM,Talwar GP,Raghupathy R

    更新日期:1991-10-01 00:00:00

  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice.

    abstract::Chicken antibodies (immunoglobulin Y; IgY) to the alpha Gal epitope (galactose alpha-1,3-galactose) bind to alpha Gal antigens of mouse and porcine tissues and endothelial cells in vitro and block human anti-alpha Gal antibody binding, complement activation and antibody-dependent cell-mediated lysis mechanisms. The ac...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2000.00136.x

    authors: Walsh WE Jr,Anderson BE,Ivancic D,Zhang Z,Piccini JP,Rodgers TG,Pao W,Fryer JP

    更新日期:2000-12-01 00:00:00

  • Induction of IgM memory with RNA from the spleens of immunized mice.

    abstract::Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:

    authors: Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

    更新日期:1981-11-01 00:00:00

  • S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways.

    abstract::Airway mucus hyperproduction is a common feature of chronic airway diseases such as severe asthma, chronic obstructive pulmonary disease and cystic fibrosis, which are closely associated with neutrophilic airway inflammation. S100A8, S100A9 and S100A12 are highly abundant proteins released by neutrophils and have been...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1111/imm.12352

    authors: Kang JH,Hwang SM,Chung IY

    更新日期:2015-01-01 00:00:00

  • Interleukin-16 stimulates the expression and production of pro-inflammatory cytokines by human monocytes.

    abstract::Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...

    journal_title:Immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2567.2000.00997.x

    authors: Mathy NL,Scheuer W,Lanzendörfer M,Honold K,Ambrosius D,Norley S,Kurth R

    更新日期:2000-05-01 00:00:00