Human secretory immunoglobulin M. An immunochemical and immunohistochemical study.

abstract：:Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete ...

journal_title：Immunology

authors： Bergstrand H

更新日期：1976-04-01 00:00:00

abstract：:The neonatal Fc receptor, FcRn, plays a central role in immunoglobulin G (IgG) transport across placental barriers. Genetic variations of FcRn-dependent transport across the placenta may influence antibody-mediated pathologies of the fetus and the newborn. Sequencing analysis of 20 unrelated individuals demonstrated n...

journal_title：Immunology

authors： Sachs UJ,Socher I,Braeunlich CG,Kroll H,Bein G,Santoso S

更新日期：2006-09-01 00:00:00

abstract：:Soluble low-affinity receptors for IgG are known to inhibit immune complex (IC)-mediated inflammation, and expression by leukocytes is elevated in several inflammatory diseases. Immunoglobulin M (IgM) rheumatoid factors (RF), anti-Fc autoantibodies, are found in autoimmune diseases, such as rheumatoid arthritis (RA), ...

journal_title：Immunology

authors： Wines BD,Gavin A,Powell MS,Steinitz M,Buchanan RR,Mark Hogarth P

更新日期：2003-06-01 00:00:00

abstract：:We have examined the distribution of the complement (C) regulatory proteins CD59, membrane cofactor protein (MCP) and decay-accelerating factor (DAF) on mature sperm and compared expression of these proteins in parallel both during spermatogenesis and in the prostate. Enhanced immunoperoxidase staining and radioimmuno...

journal_title：Immunology

authors： Simpson KL,Holmes CH

更新日期：1994-03-01 00:00:00

abstract：:In order to elucidate possible roles of thymic nurse cells (TNC) we isolated them as lympho-epithelial cell complexes from spontaneous thymomas of BUF/Mna rats and characterized them using immuno- and enzyme-histochemical techniques. A remarkable increase in the number of TNC was seen at 8 months of age, immediately b...

journal_title：Immunology

authors： Ezaki T,Matsuno K,Kotani M

更新日期：1991-06-01 00:00:00

abstract：:Rabbit IgG and its Fab, Fc and pFc' fragments, prepared by papain or peptic digestion, were assayed for binding to homologous peritoneal macrophages. The binding affinity of IgG for the peritoneal macrophages (Ka = 5.9 +/- 1.6 x 10(5) L/M) was comparable to that recorded with alveolar macrophages (7.6 +/- 1.8 x 10(5) ...

journal_title：Immunology

authors： Ganczakowski M,Leslie RG

更新日期：1979-03-01 00:00:00

abstract：:It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...

journal_title：Immunology

authors： Yoshikai Y,Matsuzaki G,Inoue T,Nomoto K

更新日期：1990-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:Toll-like receptor-4 (TLR4) is important in protection against lethal Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Control of the early stages of sublethal S. Typhimurium infection in mice depends on TLR4-dependent activation of macrophages and natural killer (NK) cells to drive an inflammatory ...

journal_title：Immunology

authors： Talbot S,Tötemeyer S,Yamamoto M,Akira S,Hughes K,Gray D,Barr T,Mastroeni P,Maskell DJ,Bryant CE

更新日期：2009-12-01 00:00:00

abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

journal_title：Immunology

authors： Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

更新日期：1981-11-01 00:00:00

abstract：:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed ...

journal_title：Immunology

authors： Hübner MP,Stocker JT,Mitre E

更新日期：2009-08-01 00:00:00

abstract：:Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized...

journal_title：Immunology

authors： Li J,Saito H,Crawford L,Inman MD,Cyr MM,Denburg JA

更新日期：2005-03-01 00:00:00

abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...

journal_title：Immunology

authors： McDonald KG,Wheeler LW,McDole JR,Joerger S,Gustafsson JK,Kulkarni DH,Knoop KA,Williams IR,Miller MJ,Newberry RD

更新日期：2017-12-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...

journal_title：Immunology

authors： La Rivière G,Klein Gebbinck JW,Schipper CA,Roos E

更新日期：1992-02-01 00:00:00

abstract：:Expression of the lymph node homing and CC-chemokine receptor 7 (CCR7), with L-selectin (CD62L), has been shown to divide human memory T cells into two functionally distinct subsets. We generated a polyclonal antibody against murine CCR7 and used this antibody to study CCR7 expression on murine T-cell subsets. Using f...

journal_title：Immunology

authors： Bjorkdahl O,Barber KA,Brett SJ,Daly MG,Plumpton C,Elshourbagy NA,Tite JP,Thomsen LL

更新日期：2003-10-01 00:00:00

abstract：:There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...

journal_title：Immunology

authors： Sehmi R,Dorman S,Baatjes A,Watson R,Foley R,Ying S,Robinson DS,Kay AB,O'Byrne PM,Denburg JA

更新日期：2003-08-01 00:00:00

abstract：:The development of T lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. T lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. SBU-T1- and SBU-T8-positive lymphocytes were seen at Day 47 of gestation. LCA, sIg, MHC I, MHC II,...

journal_title：Immunology

authors： Maddox JF,Mackay CR,Brandon MR

更新日期：1987-09-01 00:00:00

abstract：:We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...

journal_title：Immunology

authors： Zhang Y,Pacheco S,Acuna CL,Switzer KC,Wang Y,Gilmore X,Harriman GR,Mbawuike IN

更新日期：2002-03-01 00:00:00

abstract：:Attempts were made to break the tolerance of lymph node B cells to deaggregated human gamma globulin. Using allotype-congenic mice, lymph node cells from virgin or tolerant (5 mg) CBA/Igb donors were transferred tonormal CBA/Iga recipients and the proportion of responding donor B cells estimated 1 and 13 days later. T...

journal_title：Immunology

authors： Elson CJ,Taylor RB

更新日期：1977-11-01 00:00:00

abstract：:Cells of the female reproductive tract (FRT) can present antigen to naive and memory T cells. However, the effects of oestrogen, known to modulate immune responses, on antigen presentation in the FRT remain undefined. In the present study, DO11.10 T-cell antigen receptor transgenic mice specific for the class II MHC-r...

journal_title：Immunology

authors： Ochiel DO,Rossoll RM,Schaefer TM,Wira CR

更新日期：2012-01-01 00:00:00

abstract：:We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...

journal_title：Immunology

authors： Ahmad SR,Lidington EA,Ohta R,Okada N,Robson MG,Davies KA,Leitges M,Harris CL,Haskard DO,Mason JC

更新日期：2003-10-01 00:00:00

abstract：:Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 with CD4 and the T-cell receptor (TCR) complex controlled by the variab...

journal_title：Immunology

authors： Leitenberg D,Falahati R,Lu DD,Takeda A

更新日期：2007-08-01 00:00:00

abstract：:It has been suggested that tumour cell lysis by gamma-radiation induces a tumoral antigen release eliciting an immune response. It is not clear how a specific immune response in cervical cancer patients is developed after radiotherapy. This study is an attempt to investigate the role of the human papillomavirus type 1...

journal_title：Immunology

authors： Delgado FG,Martínez E,Céspedes MA,Bravo MM,Navas MC,Cómbita Rojas AL

更新日期：2009-04-01 00:00:00

abstract：:The recovery of the B-cell population in adult thymectomized, irradiated and bone marrow-reconstituted mice (T X BM mice was estimated at various times after bone marrow transplantation. The spleen cells to be tested were mixed with dexamethasone-resistant thymocytes (DRT) and sheep red blood cells (SRBC) and transfer...

journal_title：Immunology

authors： van Muiswinkel WB,van Beek JJ,van Soest PL

更新日期：1975-08-01 00:00:00

abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...

journal_title：Immunology

authors： Baker ML,Melman SD,Huntley J,Miller RD

更新日期：2009-09-01 00:00:00

abstract：:Cellular adhesion molecules play a central role in leucocyte migration through peripheral blood and tissues. A crucial stage in these events in selectin-mediated adhesion involving E-selectin expressed on activated endothelium interacting with a range of carbohydrate ligands expressed by specific subpopulations of leu...

journal_title：Immunology

authors： Ross EL,Barker JN,Allen MH,Chu AC,Groves RW,MacDonald DM

更新日期：1994-02-01 00:00:00

abstract：:Rhesus macaques (Macaca mulatta) are extensively used in vaccine development. Macaques infected with simian immunodeficiency viruses (SIV) or simian-human immunodeficiency viruses (SHIV) are the best animal model currently available for acquired-immune-deficiency-syndrome-related studies. Recent results emphasize the ...

journal_title：Immunology

authors： Scinicariello F,Engleman CN,Jayashankar L,McClure HM,Attanasio R

更新日期：2004-01-01 00:00:00

abstract：:Tuberculin-active peptide-reactive T-cell lines were established from the popliteal lymph node of BALB/cA mice immunized with heat-killed Mycobacterium tuberculosis to investigate the cellular mechanisms in the protective immunity of tuberculosis. These T-cell lines, consisting mainly of L3T4 surface antigen-positive ...

journal_title：Immunology

authors： Yamamoto S,Iwai H,Ueda K

更新日期：1989-10-01 00:00:00

abstract：:The expression of natural cytotoxicity in the gut-associated lymphoid tissue of the rat was investigated. Intra-epithelial lymphocytes (IEL) isolated from the small intestine had a similar frequency of cytotoxic and tumour target binding cells as the spleen. However, cytotoxic activity was low in Peyer's patches and m...

journal_title：Immunology

authors： Flexman JP,Shellam GR,Mayrhofer G

更新日期：1983-04-01 00:00:00

abstract：:Osteopontin (OPN) is a secreted phosphoprotein found in body fluids (e.g. plasma, urine, milk) and in mineralized tissues. Its expression is increased in many transformed cells and in normal cells exposed to various cytokines. When stimulated with the inflammatory mediators lipopolysaccharide and interferon-gamma, mou...

journal_title：Immunology

authors： Rollo EE,Denhardt DT

更新日期：1996-08-01 00:00:00