Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.

abstract：:The immunosuppressive activity of serum from PVG rats following orthotopic transplantation of DA liver has been examined in vitro. Liver grafts in this combination are never rejected, but induce a state of specific transplantation tolerance in the recipient. Serum from such tolerant animals was able to inhibit prolife...

journal_title：Immunology

authors： Tsurufuji M,Ishiguro K,Shinomiya T,Uchida T,Kamada N

更新日期：1987-08-01 00:00:00

abstract：:We identified CD8(+)  CD122(+) regulatory T cells (CD8(+)  CD122(+) Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8(+)  CD122(+) Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimen...

journal_title：Immunology

authors： Okuno Y,Murakoshi A,Negita M,Akane K,Kojima S,Suzuki H

更新日期：2013-07-01 00:00:00

abstract：:The metabolic consequences of non-lethal complement-membrane attack in neutrophils have been investigated by the measurement of cellular ATP content and functional parameters, including chemotactic and phagocytic responses and the capacity to secrete reactive oxygen metabolites, in cells before and after attack. Immed...

journal_title：Immunology

authors： Morgan BP

更新日期：1988-01-01 00:00:00

abstract：:Goats were immunized with membrane fractions of the L5178Y tumour syngenic to DBA/2 mice. IgG fractions of this antiserum were made tumour specific by repeated in vitro and in vivo absorptions with normal cells and concentrated by adsorption to and elution from tumour cells. In vivo studies indicated that the accumula...

journal_title：Immunology

authors： Froese G,Berczi I,Israels LG

更新日期：1982-02-01 00:00:00

abstract：:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior sy...

journal_title：Immunology

authors： Yang X,Wang S,Fan Y,Zhu L

更新日期：1999-11-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:Complement activation within lymph nodes has been shown to alter lymphocyte traffic through the node. Challenge of cannulated sheep lymph nodes with either immune complexes or complement activators was found to initiate the phenomenon of cell shutdown associated with antigenic challenge of lymph nodes in primed animal...

journal_title：Immunology

authors： McConnell I,Hopkins J

更新日期：1981-02-01 00:00:00

abstract：:Epidermal keratinocytes are induced to express MHC class II molecules in a variety of disease states associated with immune activity. To investigate the mechanism of this process we have exposed murine and rat keratinocytes to a variety of lymphokines and monitored changes in their MHC molecule expression. Murine cult...

journal_title：Immunology

authors： Yeoman H,Anderton JG,Stanley MA

更新日期：1989-01-01 00:00:00

abstract：:Langerhans' cells (LC) cultured for 1-3 days lose their ability to process native protein antigens but acquire the ability to stimulate resting T cells as assessed in an allogeneic mixed lymphocyte response (MLR). Lymph-borne dendritic cells (L-DC) are physiologically involved in the transport of antigens to lymph nod...

journal_title：Immunology

authors： Liu LM,MacPherson GG

更新日期：1995-02-01 00:00:00

abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...

journal_title：Immunology

authors： Sabbele NR,Van Oudenaren A,Hooijkaas H,Benner R

更新日期：1987-10-01 00:00:00

abstract：:The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon...

journal_title：Immunology

authors： Monari C,Kozel TR,Casadevall A,Pietrella D,Palazzetti B,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:We explored the mechanisms of class B CpG-oligodeoxynucleotide-induced antitumour effects against weakly immunogenic tumours. Treatment with CpG-oligodeoxynucleotide 1826 (CpG) induced similar antitumour effects in B16 melanoma-bearing immunocompetent C57BL/6 mice and T-cell-deficient severe combined immunodeficient (...

journal_title：Immunology

authors： Buhtoiarov IN,Sondel PM,Eickhoff JC,Rakhmilevich AL

更新日期：2007-03-01 00:00:00

abstract：:An examination was made of the effects of eosinophilia on acute inflammation. Sprague Dawley rats were infected with Trichinella spiralis larvae which resulted in a blood eosinophilia. Groups of rats with the induced eosinophilia, and untreated rats without the eosinophilia, were treated with carrageenan, bradykinin o...

journal_title：Immunology

authors： Popper H,Picher O,Auer H

更新日期：1982-07-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS), the percentages of T and B lymphocytes in the peripheral blood, spleen and lymph nodes of CBA syngeneic and allogeneic pregnancies were determined. At 19 days of syngeneic pregnancy, the level of T cells in the blood had decreased and that of B cells had increased. ...

journal_title：Immunology

authors： Carter J,Newport A,Keeler KD,Dresser DW

更新日期：1983-04-01 00:00:00

abstract：:Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...

journal_title：Immunology

authors： Russell MW,Challacombe SJ,Lehner T

更新日期：1976-05-01 00:00:00

abstract：:Autoimmune diabetes is predominated by a T helper 1 (Th1) response at the expense of an impaired Th2 response. Although T cells producing Th2 cytokines are generally thought to counter a Th1 response, there have been reports of Th2 T-cell clones with pathogenic activity, including one previously reported by us in whic...

journal_title：Immunology

authors： He J,Haskins K

更新日期：2008-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that involves dysregulation of B and T cells. A tolerogenic peptide, designated hCDR1, ameliorates disease manifestations in SLE-afflicted mice. In the present study, the effect of treatment with hCDR1 on the CD74/macrophage migration inhibitory factor (MIF) ...

journal_title：Immunology

authors： Lapter S,Ben-David H,Sharabi A,Zinger H,Telerman A,Gordin M,Leng L,Bucala R,Shachar I,Mozes E

更新日期：2011-01-01 00:00:00

abstract：:We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...

journal_title：Immunology

authors： Ahmad SR,Lidington EA,Ohta R,Okada N,Robson MG,Davies KA,Leitges M,Harris CL,Haskard DO,Mason JC

更新日期：2003-10-01 00:00:00

abstract：:To determine whether the availability of either B cells or T cells regulates the number and size of germinal centres observed following antigenic challenge, irradiated PVG rats were reconstituted with limiting numbers of thoracic duct B cells (with excess T cells) or with limiting numbers of thoracic duct CD4+ cells (...

journal_title：Immunology

authors： Vonderheide RH,Hunt SV

更新日期：1990-03-01 00:00:00

abstract：:In understanding the regulation of the specific immune response to Salmonella typhimurium, the role of a surface major component (porins) was studied. In this study we demonstrate that purified porins are able to induce a different response to that induced by the porins present on the S. typhimurium cell surface. Pori...

journal_title：Immunology

authors： Galdiero M,De Martino L,Marcatili A,Nuzzo I,Vitiello M,Cipollaro de l'Ero G

更新日期：1998-05-01 00:00:00

abstract：:Both lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) impeded monocyte to macrophage differentiation with respect to typical phenotypic modulation and certain phagocyte-related processes. The down-regulation of the porcine monocyte marker SWC1, and up-regulation of the SWC9 macrophage marker were ret...

journal_title：Immunology

authors： Basta S,Knoetig S,Summerfield A,McCullough KC

更新日期：2001-08-01 00:00:00

abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...

journal_title：Immunology

authors： Polson RJ,Jenkins R,Lombard M,Williams AC,Roberts S,Nouri-Aria K,Williams R,Bomford A

更新日期：1990-10-01 00:00:00

abstract：:The B-cell development in a group of rats was suppressed for the first 45 days of life by serial administration of rabbit anti-rat IgM and IgD antibody. Total or near total suppression of B lymphopoiesis was achieved. At 45 days, suppression was stopped by injection of IgM and IgD rat paraproteins. The sequence of B-c...

journal_title：Immunology

authors： Bazin H,Platteau B,Maclennan IC,Johnson GD

更新日期：1985-01-01 00:00:00

abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...

journal_title：Immunology

authors： Sminia T,Delemarre F,Janse EM

更新日期：1983-09-01 00:00:00

abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...

journal_title：Immunology

authors： Zhong W,Su W,Zhang Y,Liu Q,Wu J,Di C,Zhang Z,Xia Z

更新日期：2014-06-01 00:00:00

abstract：:Previously, a putative immunosuppressant-coding gene was identified from a complementary DNA library derived from the salivary glands of partially-fed Haemaphysalis longicornis. Using real-time polymerase chain reaction, the gene was shown to be predominantly expressed during blood feeding with the site of expression ...

journal_title：Immunology

authors： Konnai S,Nakajima C,Imamura S,Yamada S,Nishikado H,Kodama M,Onuma M,Ohashi K

更新日期：2009-02-01 00:00:00

abstract：:Mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP3K family. Recently, we found that MEKK3 plays a critical role in interleukin-1 (IL-1) receptor and Toll-like receptor 4 signalling using established primary mouse embryonic fibroblast (MEF)...

journal_title：Immunology

authors： Kim K,Duramad O,Qin XF,Su B

更新日期：2007-02-01 00:00:00

abstract：:In Trichinella spiralis-infected rats, a population of cells in thoracic duct lymph (TDL) that can adoptively transfer protection to naive rats was identified and characterized. During the course of T. spiralis infection, blast cells appeared in lymph from Day 3-4, and only Day 3-4 TDL cells had protective properties ...

journal_title：Immunology

authors： Bell RG,Korenaga M,Wang CH

更新日期：1987-06-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00