Reduction of carrageenan- bradykinin- and histamine-induced acute inflammation by experimental eosinophilia in rats.

abstract：:The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...

journal_title：Immunology

authors： Roche M,Kelly JP,O'Driscoll M,Finn DP

更新日期：2008-10-01 00:00:00

abstract：:The role of gut-derived CD4+ T cells in clearance of Pseudomonas aeruginosa from the lung was studied by cell transfer experiments. Mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed P. aeruginosa or Helicobacter pylori, were transferred to naive rats which were subsequently...

journal_title：Immunology

authors： Dunkley ML,Clancy RL,Cripps AW

更新日期：1994-11-01 00:00:00

abstract：:The fungus metabolite cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. It is effective following either parenteral or oral administration in mice, rats and guinea-pigs. The suppressive effect after short and prolonged treatment on plaque-forming cells, the inhibition of the secondary hu...

journal_title：Immunology

authors： Borel JF,Feurer C,Magnée C,Stähelin H

更新日期：1977-06-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...

journal_title：Immunology

authors： Brent L

更新日期：2016-03-01 00:00:00

abstract：:A serum factor, believed to be an IgG autoantibody, in certain patients with lepromatous leprosy inhibits the proliferation of mitogen-stimulated lymphocytes. To investigate which stage of the cell cycle was inhibited, we examined the effect of these sera on the kinetics of lymphocyte activation induced by several mit...

journal_title：Immunology

authors： Poulton TA,Gallagher A,Beck JS

更新日期：1989-11-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00

abstract：:The non-specific normal immunosuppressive protein (Nip) has been described in our laboratory and its biological activity was extensively studied. In the present study, further purification analyses of Nip were conducted. Fractionation of Nip by Ultrogel AcA 34 column resulted in peak (I) that displayed Nip activity in...

journal_title：Immunology

authors： Gavison-Goren R,Nelken D

更新日期：1983-08-01 00:00:00

abstract：:The number, distribution and surface phenotype of dividing cells in the thymus, and differences between the cell cycle status of thymocyte subpopulations, were studied in fetal and post-natal lambs using double-labelling techniques. Dividing cells were labelled in vivo for various periods with 5-bromo-2-deoxyuridine (...

journal_title：Immunology

authors： McClure S,Dudler L,Thorpe D,Hein WR

更新日期：1988-11-01 00:00:00

abstract：:The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...

journal_title：Immunology

authors： Berahovich RD,Zabel BA,Lewén S,Walters MJ,Ebsworth K,Wang Y,Jaen JC,Schall TJ

更新日期：2014-01-01 00:00:00

abstract：:The fate of allogeneic lymphocytes (AO or DA) transferred to non-immune PVG recipients was studied in the light of previous evidence (Heslop & McNeilage, 1983; Rolstad & Ford, 1983) that allogeneic lymphocytes can be rapidly destroyed in certain strain combinations of rats and mice by a mechanism that is distinct from...

journal_title：Immunology

authors： Rolstad B,Fossum S,Bazin H,Kimber I,Marshall J,Sparshott SM,Ford WL

更新日期：1985-01-01 00:00:00

abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...

journal_title：Immunology

authors： Costalonga M,Zell T

更新日期：2007-09-01 00:00:00

abstract：:In this report the antigen and restriction specificity of human T-cell clones induced with Dermatophagoides farinae (D. farinae) and isolated from an atopic individual with perennial rhinitis has been investigated. Of the six clones analysed, four were species specific and two showed cross-reactivity for the closely r...

journal_title：Immunology

authors： O'Hehir RE,Eckels DD,Frew AJ,Kay AB,Lamb JR

更新日期：1988-08-01 00:00:00

abstract：:Human cells are relatively resistant to lysis by the homologous complement system. Here we describe the mechanism of action of a recently discovered and widely distributed 18,000-20,000 molecular weight (MW) membrane glycoprotein (CD59), which appears to act as a major protective element against complement-mediated ly...

journal_title：Immunology

authors： Meri S,Morgan BP,Davies A,Daniels RH,Olavesen MG,Waldmann H,Lachmann PJ

更新日期：1990-09-01 00:00:00

abstract：:The effect of intravenous (i.v.) administration of bacterial alpha-amylase (B alpha A) on the IgG antibody response to a subsequent challenge with B alpha A in incomplete Freund's adjuvant (IFA) varied with the difference in responsiveness of the parental strains. High-responder C3H/He (C3) mice given injections of ei...

journal_title：Immunology

authors： Nakashima S

更新日期：1986-02-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all fo...

journal_title：Immunology

authors： Redman CW,McMichael AJ,Stirrat GM,Sunderland CA,Ting A

更新日期：1984-07-01 00:00:00

abstract：:Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophil...

journal_title：Immunology

authors： Lv J,Zou L,Zhao L,Yang W,Xiong Y,Li B,He R

更新日期：2015-09-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:The Ager assay was adapted to a porcine lymphocyte-rat high endothelial cell (HEC) system. Using this in vitro assay, the role of porcine CD44 in lymphocyte binding to HEC was examined. The results show that the presence of soluble CD44 molecules did not inhibit the binding of porcine lymphocytes to the cultured rat H...

journal_title：Immunology

authors： Yang H,Binns RM

更新日期：1993-07-01 00:00:00

abstract：:CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence ...

journal_title：Immunology

authors： De Berardinis P,Londei M,Carrel S,Feldmann M

更新日期：1988-07-01 00:00:00

abstract：:Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...

journal_title：Immunology

authors： Giunti D,Parodi B,Cordano C,Uccelli A,Kerlero de Rosbo N

更新日期：2014-03-01 00:00:00

abstract：:Many delayed-type reactions contain large infiltrates of basophils whose function is unknown. We have studied these cutaneous basophil hypersensitivity (CBH) reactions in guinea-pigs to ascertain whether basophils that are recruited to delayed reaction sites could be triggered for immediate reactivity. We compared 24 ...

journal_title：Immunology

authors： Askenase PW,Debernardo R,Tauben D,Kashgarian M

更新日期：1978-11-01 00:00:00

abstract：:A suppressive B-cell factor (SBF)-producing hybridoma termed TS-4.44 was established by fusion of B cells which possessed receptors for the Fc portion of IgG (FcR gamma + B cells) and thymidine kinase defective fibroblasts, 3T3-4E cells. The biological properties of hybridoma-produced SBF (Hyb-SBF) are almost the same...

journal_title：Immunology

authors： Suzuki T,Miyama-Inaba M,Masuda T,Uchino H,Ishii K

更新日期：1983-12-01 00:00:00

abstract：:We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the Ly49A receptor. Affinity chromatography using peptides corresponding to the N-terminal 18 amino acids of Ly49A allowed the recovery of a number of proteins that bound preferentially to the ty...

journal_title：Immunology

authors： Daws MR,Eriksson M,Oberg L,Ullén A,Sentman CL

更新日期：1999-08-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...

journal_title：Immunology

authors： Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DL

更新日期：1989-08-01 00:00:00

abstract：:Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...

journal_title：Immunology

authors： Katz FE,Steward MW

更新日期：1975-09-01 00:00:00

abstract：:Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...

journal_title：Immunology

authors： Hughes CC,Male DK,Lantos PL

更新日期：1988-08-01 00:00:00

abstract：:To determine whether the paracrine secretion of interleukin-12 (IL-12) can efficiently stimulate the resistance to Mycobacterium avium complex (MAC) infection, 3T3 fibroblasts were stably transfected to secrete IL-12 (480 U/106 cells/48 hr) and their effect on MAC infection was investigated in genetically susceptible ...

journal_title：Immunology

authors： Kang BY,Chung SW,Lim YS,Kim EJ,Kim SH,Hwang SY,Kim TS

更新日期：1999-07-01 00:00:00