Abstract：
:Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interaction between the lymphocytes and endothelial cells--by brief co-culture of lymph node cells with monolayers of cultured cerebral endothelium. In this system we find that the basal level of adhesion can be increased in a dose-dependent manner by pre-treatment of the endothelial cells with interferon-gamma (IFN-gamma) and/or tumour necrosis factor (TNF) but not with interleukin-1 (IL-1). This increased adhesion can be blocked by incubating the IFN-gamma-treated cells with an antibody that is thought to bind to the common beta-chain of the lymphocyte functional antigen-1 (LFA-1) family of molecules. This suggests that endothelial cells express either LFA-1 or a molecule sharing the beta-subunit (of which several have been described) and furthermore that this molecule is involved in the regulation of lymphocyte traffic into the brain.
journal_name
Immunologyjournal_title
Immunologyauthors
Hughes CC,Male DK,Lantos PLsubject
Has Abstractpub_date
1988-08-01 00:00:00pages
677-81issue
4eissn
0019-2805issn
1365-2567journal_volume
64pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:We and others have established an important role for phosphoinositide-3 kinase gamma (PI3Kgamma) in the chemotactic responses of macrophages and neutrophils. The involvement of this lipid kinase in allergic inflammatory responses is, however, yet to be fully determined. Here we compare wild-type (WT) and PI3Kgamma(-/-...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02908.x
更新日期：2009-03-01 00:00:00
abstract：:Mice fed a protein-deficient diet containing 2% ovalbumin for 6 weeks (PD) show a reduced spleen IgA plaque-forming cell (PFC) response after oral immunization with sheep red blood cells (SRBC), compared to the response of mice fed a control diet containing 20% ovalbumin (C). This reduced IgA PFC response was partiall...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02683.x
更新日期：2008-03-01 00:00:00
abstract：:Resident glomerular macrophages from normal rats were isolated and grown through long-term cultures in order to obtain confluent cell monolayers. These cells have a secretory function as revealed by the production of a cytokine with a molecular weight similar to interleukin-1 (IL-1). The demonstration that rat glomeru...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) phenotype becomes stable...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12068
更新日期：2013-06-01 00:00:00
abstract：:Cutaneous delayed hypersensitivity reactions to collagen in guinea-pigs were partially but specifically suppressed if the animals had been pretreated with collagen and Freund's incomplete adjuvant. Such animals responded normally to skin-reactive factor prepared with ovalbumin. Lymphoid cells from animals with normal ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:Mucosa-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor TRAV1-2 and detect a range of bacteria and fungi through the MHC-like molecule MR1. However, knowledge of the function and phenotype of bacteria-reactive MR1-restricted TRAV1-2(+) MAIT cells from human blood is limited. We broadly ch...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12461
更新日期：2015-07-01 00:00:00
abstract：:Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all fo...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2008.03050.x
更新日期：2009-03-01 00:00:00
abstract：:Cells subjected to nucleoside incorporation studies using radiolabelled materials may suffer radiation damage that can alter the results. We did scintimetric and cytofluorographic analysis to confirm this and to determine the optimal experimental doses of, and exposure times to, [3H]-TdR, in order to prevent or minimi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：:Tick larvae (Boophilus microplus) were extracted, fractionated by gel filtration and ion-exchange chromatography, and the fractions assayed by enzyme-linked immunosorbent assay (ELISA) against sera from cattle immunized and protected by antigens from the mid-gut of adult ticks. Unfractionated, whole larval extracts an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:CD27 is a T-cell surface antigen expressed on the majority of peripheral T cells and belongs to a newly defined receptor family including the low-affinity nerve growth factor receptor, tumour necrosis factor (TNF) receptors, the B-cell activation antigen CD40, and the Fas antigen. Although the function of CD27 has not...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Over the last few years, natural killer (NK) cells have been shown to express major histocompatibility complex (MHC) molecules recognizing receptors that are thought to function primarily as negative signalling receptors. Much attention has been focused on the NK cell receptors CD158a (EB6) and CD158b (GI 183), which ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00374.x
更新日期：1997-12-01 00:00:00
abstract：:Efferent lymph from the popliteal node of sheep challenged with antigen was found to suppress the in vitro transformation of sheep peripheral blood lymphocytes to a variety of antigens. The suppressor factor appeared 6-20 hr after challenged of the node and was shown to be prostaglandin E2, probably complexed to album...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：:The immunosuppressive effect of cyclosporin A (CS-A) was investigated in RIC-Sprague-Dawley rats. In vivo, CS-A totally abolished the formation of antibodies to the hapten dinitrophenyl (DNP) in rats immunized with DNP-keyhole limpet haemocyanin. In vitro, the effect of CS-A was investigated in spleen cell cultures st...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:Infection of susceptible mice with murine cytomegalovirus (MCMV) induces persistent inflammation, and the production of autoantibodies reactive with large numbers of proteins from all major organs. However the roles of polyclonal B-cell activation, autoreactive T-helper cells and host-virus cross-reactions in these ph...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Macrophages have the potential to recognize apoptotic neutrophils and phagocytose them while the same function for monocytes is uncertain. In fact, early findings indicated that monocytes started to phagocytose neutrophils on the third day of differentiation to macrophages. Here we show, using flow cytometry and confo...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03087.x
更新日期：2009-09-01 00:00:00
abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:Two phenotypically distinct subpopulations of dendritic cells (SIRPalpha+ CC81Ag- DC and SIRPalpha- CC81Ag+ DC) have previously been identified in bovine afferent lymph which show functional differences when assayed in vitro. The purpose of this study was to investigate whether differences in cytokine production betwe...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2003.01712.x
更新日期：2003-09-01 00:00:00
abstract：:Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02753.x
更新日期：2008-06-01 00:00:00
abstract：:The kinetics of ingestion and degradation of guinea-pig IgG2-containing soluble immune complexes by guinea-pig macrophages and neutrophils have been compared and aspects of the biochemical control of these events in neutrophils have been investigated using a selection of inhibitors. Differences were observed between t...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1-9 of myelin basic protein (MBP), inhibited T-cell responsiveness in vitro and induced tolerance in the H-2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1-9[4Y] wit...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00795.x
更新日期：1999-06-01 00:00:00
abstract：:This paper describes experiments undertaken to determine more uniform conditions for the generation of cytotoxic lymphokine--'lymphotoxin' (LT) in differently stimulated rat lymphocyte cultures, and to compare the sensitivity of different test systems for detecting rat LT activity in vitro. Wistar rat lymphoid cells w...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:Newborn mammals are highly susceptible to respiratory infections. Although maternal antibodies (MatAb) offer them some protection, they may also interfere with their systemic immune response to vaccination. However, the impact of MatAb on the neonatal mucosal immune response remains incompletely described. This study ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12222
更新日期：2014-04-01 00:00:00
abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12046
更新日期：2013-03-01 00:00:00
abstract：:An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Mice infected by intraperitoneal injection of Mycobacterium tuberculosis were studied over a 23-week period. They showed progressive infection in the lung (with increasing microbial count and granuloma size) whereas viable bacillary counts remained largely stationary in the spleen and in the liver. The influence of H-...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Mutation of the interleukin-2 (IL-2) receptor gamma chain, which also serves as a component of the receptor complexes for IL-4, 7, 9 and 15, results in severe immune deficiency. We hypothesized that the immunological immaturity of healthy neonates might be associated with low levels of expression of this receptor mole...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Compared with non-transgenic controls, mice bearing an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparabl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00157.x
更新日期：1997-02-01 00:00:00
