Abstract：
:Compared with non-transgenic controls, mice bearing an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparably to non-transgenic controls. Unimmunized transgenic mice were found to have CTL precursors, which could be activated by in vitro stimulation, specific for viral (and self) envelope protein (Env). This "spontaneous priming' for antiviral CTL is surprising because the transgene Env is present on the surface of thymocytes and in serum from before birth. Our experiments demonstrate that T cells reactive with self-thymic and serum antigens sometimes avoid clonal elimination or inactivation.
journal_name
Immunologyjournal_title
Immunologyauthors
Nihrane A,Silver Jdoi
10.1046/j.1365-2567.1997.00157.xsubject
Has Abstractpub_date
1997-02-01 00:00:00pages
219-28issue
2eissn
0019-2805issn
1365-2567journal_volume
90pub_type
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