Abstract:
:To define the role of memory T cells in a non-persistent viral infection, we have delineated the phenotype of memory CD8+ T cells specific for influenza A virus (FluA; matrix protein M158-66) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of FluA-specific CD8+ T cells expressed CD27 and CD28, and variably expressed CD45RA, CD62L, CD94 and granzyme A. A majority of FluA-specific CD8+ T cells expressed high levels of CXCR3, and moderate levels of CCR5 and CXCR4, whereas a limited proportion expressed CCR7, CCR6 and CXCR5. A phenotypic profile based on these observations showed that there are both immature and mature memory CD8+ T cells specific for FluA.
journal_name
Immunologyjournal_title
Immunologyauthors
Hoji A,Rinaldo CR Jrdoi
10.1111/j.1365-2567.2005.02135.xkeywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
239-45issue
2eissn
0019-2805issn
1365-2567pii
IMM2135journal_volume
115pub_type
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