Synergy between interleukin-2 and a second factor in the long-term growth of human T cells.

abstract：:The immunosuppression exhibited by a water-soluble condensate of tobacco smoke (WSC) has been studied in vivo and in vitro. When multiple sublethal doses of WSC were injected into C57Bl/6 mice, their ability to respond to immunization with sheep erythrocytes by the formation of plaque-forming cells was severely inhibi...

journal_title：Immunology

authors： Jacob CV,Stelzer GT,Wallace JH

更新日期：1980-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin-9 (IL-9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR-15b and miR-16) that we previously found to play an important role in re...

journal_title：Immunology

authors： Singh Y,Garden OA,Lang F,Cobb BS

更新日期：2016-09-01 00:00:00

abstract：:Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro-inflammatory cytokine interleukin(IL)-1β. Here, primarily using an in vitro inflammasome ASC spec...

journal_title：Immunology

authors： Nizami S,Arunasalam K,Green J,Cook J,Lawrence CB,Zarganes-Tzitzikas T,Davis JB,Di Daniel E,Brough D

更新日期：2021-01-01 00:00:00

abstract：:Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polys...

journal_title：Immunology

authors： Dracott BN,Wedderburn N,Doenhoff MJ

更新日期：1978-04-01 00:00:00

abstract：:The cellular elements of an antigen-specific suppressor system for secondary antibody responses have been identified, using positive cell-selection techniques in the fluorescence-activated cell sorter. In a double-adoptive transfer of memory cells for a thymus-dependent antigen, from one irradiated recipient to anothe...

journal_title：Immunology

authors： Thomas DB,Kennedy MW

更新日期：1983-10-01 00:00:00

abstract：:Male lymphocytic choriomeningitis (LCM) virus-carrier mice were mated to uninfected females and their offsprings tested for (i) LCMV virus and (ii) their potential to generate LCM virus-specific cytotoxic T cells. Among about 500 offspring tested no example of antigen-independent inheritance of tolerance to LCM virus ...

journal_title：Immunology

authors： Stitz L,Zinkernagel RM

更新日期：1984-06-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...

journal_title：Immunology

authors： Specht Grijp-Glandorf RJ,De Heer E,Dekker-Nooren CC,Daha MR,Van Es LA

更新日期：1990-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:In order to identify and characterize the sheep major histocompatibility complex (MHC) class II molecules, a panel of 19 monoclonal antibodies (mAb) has been raised following immunization of mice with a variety of class II antigen preparations. Antibodies were selected by ELISA using immunopurified sheep class II as a...

journal_title：Immunology

authors： Dutia BM,Hopkins J,Allington MP,Bujdoso R,McConnell I

更新日期：1990-05-01 00:00:00

abstract：:The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...

journal_title：Immunology

authors： Ray A,Dittel BN

更新日期：2015-11-01 00:00:00

abstract：:It has been demonstrated that the single autosomal recessive lpr and gld genes are responsible for the accumulation of unusual T-cell subsets. Although these subsets have been assigned to the T-cell lineage, they share certain antigenic cell surface markers with mature B lymphocytes. Consequently the maturational path...

journal_title：Immunology

authors： Waterfield JD,Fairhurst M

更新日期：1991-02-01 00:00:00

abstract：:The gut microbiota provides an important stimulus for the induction of regulatory T (Treg) cells in mice, whether this applies to newborn children is unknown. In Swedish children, Staphylococcus aureus has become a common early colonizer of the gut. Here, we sought to study the effects of bacterial stimulation on neon...

journal_title：Immunology

authors： Rabe H,Nordström I,Andersson K,Lundell AC,Rudin A

更新日期：2014-03-01 00:00:00

abstract：:It is increasingly becoming clear that various immune cells are infected by the very pathogens that they are supposed to attack. Although many mechanisms for microbial entry exist, it appears that a common route of entry shared by certain bacteria, viruses and parasites involves cellular lipid-rich microdomains someti...

journal_title：Immunology

authors： Shin JS,Abraham SN

更新日期：2001-01-01 00:00:00

abstract：:The cellular prion protein (PrPc) is a glycosyl-phosphatidylinositol (GPI)-linked cell surface protein, which is expressed at high density on nervous tissues and at lower levels on most other solid-organ tissues. It is also expressed on peripheral blood mononuclear cells (PBMC) of all lineages. In lymphocytes, its lev...

journal_title：Immunology

authors： Morelon E,Dodelet V,Lavery P,Cashman NR,Loertscher R

更新日期：2001-02-01 00:00:00

abstract：:The delayed-type-hypersensitivity (DTH) reaction observed in mice primed i.v. with low doses of sheep red blood cells is not detectable after priming with large doses. Estimation of the number of DTH mediating cells (DTH-C) was performed by titration (D50 determination) using local adoptive transfer of these cells mix...

journal_title：Immunology

authors： Marchal G,Milon G,Hurtrel B,Lagrance PH

更新日期：1978-12-01 00:00:00

abstract：:A group of fifteen rabbits were immunized five times, at weekly intervals, by intravenous injection of mouse thymocytes. After an interval of 3 months the rabbits were then re-immunized three times at intervals of 7 days. The rabbits were bled prior to the commencement of immunization to obtain normal rabbit serum (NR...

journal_title：Immunology

authors： Lai T,Symes MO

更新日期：1976-07-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:Studies in long-term non-progressors (LTNP) have suggested that the quality of the CD8(+) response may involve protective human leucocyte antigen (HLA) class I alleles. However, studies examining the expansion ability of different functional CD8(+) T cells and their association with HLA class I alleles are lacking. LT...

journal_title：Immunology

authors： López M,Peris A,Soriano V,Lozano S,Vicario JL,Rallón NI,Restrepo C,Benito JM

更新日期：2011-11-01 00:00:00

abstract：:The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...

journal_title：Immunology

authors： Inagaki-Ohara K,Sakamoto Y,Dohi T,Smith AL

更新日期：2011-12-01 00:00:00

abstract：:Ribonucleic acid (RNA) extracts were obtained from lymph nodes of guinea-pigs that had previously been immunized with a purified testicular antigen emulsified in Freund's complete adjuvant. The RNA extracts were incubated with normal guinea-pig peritoneal exudate cells (NGP-PEC). After treatment, the NGP-PEC cells sho...

journal_title：Immunology

authors： Fainboim L,Sztein MB,Serrate S,Satz L

更新日期：1979-10-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...

journal_title：Immunology

authors： Kudo F,Ikutani M,Seki Y,Otsubo T,Kawamura YI,Dohi T,Oshima K,Hattori M,Nakae S,Takatsu K,Takaki S

更新日期：2016-01-01 00:00:00

abstract：:Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...

journal_title：Immunology

authors： Casado JA,Merino J,Cid J,Subira ML,Sanchez-Ibarrola A

更新日期：1994-09-01 00:00:00

abstract：:The decay-accelerating factor (DAF) contains four complement control protein repeats (CCPs) with a single N-linked glycan positioned between CCPs 1 and 2. In previous studies we found that the classical pathway regulatory activity of DAF resides in CCPs 2 and 3 while its alternative pathway regulatory activity resides...

journal_title：Immunology

authors： Brodbeck WG,Kuttner-Kondo L,Mold C,Medof ME

更新日期：2000-09-01 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...

journal_title：Immunology

authors： Brenden N,Böhme J

更新日期：1998-09-01 00:00:00

abstract：:Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). We have investigated the effect of gangliosides on the interaction of IL-2 wit...

journal_title：Immunology

authors： Chu JW,Sharom FJ

更新日期：1993-05-01 00:00:00

abstract：:Although it is well known that cases with silicosis exhibit various immunological abnormalities, the mechanisms involved in the occurrence of immuno-dysfunction or dysregulation induced by silica compounds have not yet been determined. Fas is a well-known cell surface molecule that is involved in the apoptosis pathway...

journal_title：Immunology

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Kawakami Y,Kusaka M,Ueki H,Kita S,Ueki A

更新日期：1998-06-01 00:00:00