Abstract：
:The cellular elements of an antigen-specific suppressor system for secondary antibody responses have been identified, using positive cell-selection techniques in the fluorescence-activated cell sorter. In a double-adoptive transfer of memory cells for a thymus-dependent antigen, from one irradiated recipient to another, antigen-specific suppressor T cells are recruited after a critical time in the primary recipient. It is also a source of B cells that are able to induce further suppressors in carrier-primed, but otherwise naive donors. There are two distinct routes, therefore, for the generation of suppressor T cells: primary induction by adoptive transfer with antigen, or secondary induction by B cells recruited in the primary irradiated host. We have shown that both primary and secondary suppressors are recruited from a Lyt 2- memory population, although the Lyt 2 alloantigen is expressed at the effector stage.
journal_name
Immunologyjournal_title
Immunologyauthors
Thomas DB,Kennedy MWsubject
Has Abstractpub_date
1983-10-01 00:00:00pages
289-95issue
2eissn
0019-2805issn
1365-2567journal_volume
50pub_type
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