The 5' coding sequence of IL-2 receptor alpha chain mRNA mediates mRNA stabilization by HTLV-1 Rex.

abstract：:We have studied the antibody response in vitro of spleen cells from C57BL/6 mice kept on a protein deficient (D) or a normal diet (N). Short or long term protein restriction initiated after weaning led to increased plaque forming cell (PFC) responses to sheep red blood cells (SRBC), TNP-ficoll and TNP lipopolysacchari...

journal_title：Immunology

authors： Pocino M,Malavé I

更新日期：1981-06-01 00:00:00

abstract：:Previous studies have highlighted the importance of CD4+ T cells in regulation of IgA responses and have indicated a functional heterogeneity among these cells between inductive (Peyer's patch) and effector (lamina propria) sites in the intestine. To determine whether these functional differences could be accounted fo...

journal_title：Immunology

authors： Bao S,Goldstone S,Husband AJ

更新日期：1993-12-01 00:00:00

abstract：:The adoptive transfer of immunity by means of spleen and lymph node cells has been analysed in rabbits of defined major histocompatibility (RLA) types and immunoglobulin (Ig) allotypes. Previous results had shown that chimaeras formed by transplanting adult cells into RLA-matched newborn hosts become stable B-lymphocy...

journal_title：Immunology

authors： Claassen E,Adler LT,Saito K,Yoshio T,Adler FL

更新日期：1987-01-01 00:00:00

abstract：:GD3, a ganglioside expressed on melanoma, is the only tumour-associated glycolipid described to date that can induce a CD1d-restricted natural killer T (NKT)-cell response. We analysed the fine specificity of GD3-reactive NKT cells and discovered that immunization with GD3 induced two populations of GD3-reactive NKT c...

journal_title：Immunology

authors： Park JE,Wu DY,Prendes M,Lu SX,Ragupathi G,Schrantz N,Chapman PB

更新日期：2008-01-01 00:00:00

abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...

journal_title：Immunology

authors： Crittenden MR,Thanarajasingam U,Vile RG,Gough MJ

更新日期：2005-01-01 00:00:00

abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...

journal_title：Immunology

authors： Kappel M,Diamant M,Hansen MB,Klokker M,Pedersen BK

更新日期：1991-07-01 00:00:00

abstract：:Previously, a putative immunosuppressant-coding gene was identified from a complementary DNA library derived from the salivary glands of partially-fed Haemaphysalis longicornis. Using real-time polymerase chain reaction, the gene was shown to be predominantly expressed during blood feeding with the site of expression ...

journal_title：Immunology

authors： Konnai S,Nakajima C,Imamura S,Yamada S,Nishikado H,Kodama M,Onuma M,Ohashi K

更新日期：2009-02-01 00:00:00

abstract：:Using mast cell-deficient mutant W/Wv mice and their normal counterpart we re-evaluated the significance of participation of mast cells in allergic inflammatory response. W/Wv mice developed immediate hypersensitivity (IH) footpad reaction (FPR) to a somewhat lesser degree than the normal mice, suggesting that the mas...

journal_title：Immunology

authors： Torii I,Morikawa S,Harada T,Kitamura Y

更新日期：1993-03-01 00:00:00

abstract：:Typhoid fever is a persistent infection caused by host-adapted Salmonella strains adept at circumventing immune-mediated host defences. Given the importance of T cells in protection, the culling of activated CD4+ T cells after primary infection has been proposed as a potential immune evasion strategy used by this path...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Mysz MA,Nanton MR,Rowe JH,Aguilera MN,Way SS

更新日期：2011-12-01 00:00:00

abstract：:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...

journal_title：Immunology

authors： Kruger M,Coorevits L,De Wit TP,Casteels-Van Daele M,Van De Winkel JG,Ceuppens JL

更新日期：1996-01-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Bovine peripheral blood monocytes were isolated from buffy coats of ACD-anticoagulated whole blood. Cells cultivated on plastic surfaces for 20 h were judged to be 95% monocytes based on nonspecific esterase-1 staining, uptake of latex particles and surface receptor characteristics. Bovine monocytes were maintained up...

journal_title：Immunology

authors： Birmingham JR,Jeska EL

更新日期：1980-12-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...

journal_title：Immunology

authors： Ip WK,Wong CK,Li ML,Li PW,Cheung PF,Lam CW

更新日期：2007-12-01 00:00:00

abstract：:The expanded CD8+ T-lymphocyte population arising in response to viral infection controls the virus but could also prove damaging to the host unless safely removed at the end of the immune response. Apoptosis provides a mechanism whereby this can be achieved, as apoptotic cells are recognized and engulfed by macrophag...

journal_title：Immunology

authors： Borthwick NJ,Bofill M,Hassan I,Panayiotidis P,Janossy G,Salmon M,Akbar AN

更新日期：1996-08-01 00:00:00

abstract：:Human leukaemia and lymphoma cell lines were investigated as stimulating cells in an allogeneic mixed lymphocyte response. Purified T cells and unfractionated mononuclear cells from normal donors were used as responders. The cell lines fell into three groups: (i) those which stimulated allogeneic responder T cells in ...

journal_title：Immunology

authors： O'Keefe D,Ashman L

更新日期：1982-12-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...

journal_title：Immunology

authors： Rückert R,Brandt K,Ernst M,Marienfeld K,Csernok E,Metzler C,Budagian V,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2009-01-01 00:00:00

abstract：:Bisphenol A (BPA) and p-nonylphenol (NP) are representative endocrine disruptors (EDs) that may have adverse effects on human health. The influence of these compounds on allergic immune responses remains unclear. In this study, we have examined the effects of BPA and NP on production of interleukin-4 (IL-4), a pro-inf...

journal_title：Immunology

authors： Lee MH,Chung SW,Kang BY,Park J,Lee CH,Hwang SY,Kim TS

更新日期：2003-05-01 00:00:00

abstract：:Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to oc...

journal_title：Immunology

authors： Darlow JM,Stott DI

更新日期：2005-02-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:The molecular mechanisms underlying B- and T-cell development are, as yet, poorly understood. However, as G proteins regulate a diverse range of biological responses including growth, proliferation and differentiation, we have investigated differential expression of G proteins during B- and T-cell development with the...

journal_title：Immunology

authors： Grant KR,Harnett W,Milligan G,Harnett MM

更新日期：1997-04-01 00:00:00

abstract：:Different cell types, including dendritic cells, macrophages and Ia+ B cells, have been described to present soluble antigen (Ag) to T-cell hybridomas. However, it is still not clear whether these different cell types can act as antigen-presenting cells (APC) for complex and insoluble Ag such as viral particles. Using...

journal_title：Immunology

authors： Scheerlinck JP,Burssens G,Brys L,Michel A,Hauser P,De Baetselier P

更新日期：1991-05-01 00:00:00

abstract：:Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...

journal_title：Immunology

authors： Galili U

更新日期：2013-09-01 00:00:00

abstract：:The contribution of B7 molecules to the induction and maintenance of the T-cell response to the human pathogenic fungus Cryptococcus neoformans was investigated. T-cell activation by C. neoformans was regulated by B7 molecules. This costimulatory signal was necessary for initiation and maintenance of the T-cell respon...

journal_title：Immunology

authors： Monari C,Kozel TR,Casadevall A,Pietrella D,Palazzetti B,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:Interleukin-3 activity is produced by T cells at an early phase after antigenic stimulation, and its quantitation provides a sensitive and non-destructive method for assaying T-cell activation. It can be detected before increased uptake of [3H]thymidine into DNA occurs, and is more sensitive than measuring [3H]thymidi...

journal_title：Immunology

authors： Dotsika EN,Sanderson CJ

更新日期：1987-12-01 00:00:00

abstract：:It is shown that the binding of bivalent anti-immunoglobulin preparations to the surface immunoglobulin of murine B lymphocytes as well as the binding of aggregates of IgG or immune complexes does not lead to detectable increase in cell division in microcultures. Treating lymphocytes with immune complexes and aggregat...

journal_title：Immunology

authors： Ramasamy R

更新日期：1976-04-01 00:00:00

abstract：:Intestinal inflammatory disease or infection often results in the loss of the epithelial layer as a result mainly of the action of proteases, including the leucocyte serine proteinases (neutrophil elastase), lysosomal cathepsins and the matrix metalloproteinases from recruited inflammatory cells. Previous studies have...

journal_title：Immunology

authors： Miller TL,McGee DW

更新日期：2002-01-01 00:00:00

abstract：:Fibronectin (FN) is a major constituent of the extracellular matrix. We now provide evidence for a surface-associated isoform of FN that is synthesized by T cells upon activation. The T-cell-derived FN has an unusual splice pattern: an additional domain, EDB, is produced whereas sequences within another domain, IIICS,...

journal_title：Immunology

authors： Wagner C,Bürger A,Radsak M,Blum S,Hug F,Hänsch GM

更新日期：2000-04-01 00:00:00

abstract：:Stimulated T lymphocytes and certain T-cell hybridomas secrete molecules capable of inducing B-lymphocyte proliferation and differentiation. It has been shown recently that one such B-cell stimulatory factor is associated with chondroitin sulphate proteoglycan (CSPG) and was designated T-cell proteoglycan fraction, or...

journal_title：Immunology

authors： Levitt D

更新日期：1988-08-01 00:00:00

abstract：:Porcine alveolar macrophages (AM) metabolize leukotriene D4 (LTD4) to leukotriene E4 (LTE4). In the present study, the ability of a fluid-phase AM stimulus (A23187) and a phagocytic stimulus (opsonized zymosan) to augment LTD4 metabolism was examined. Both stimuli increased the release of superoxide (O-2) anions. Howe...

journal_title：Immunology

authors： Paterson NA,McIver DJ,Schurch S

更新日期：1985-09-01 00:00:00

abstract：:Among peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive. However, here we show, using flow cytometric analysis, that ex vivo approximately 6% of rat T cells stained for both CD4 and CD8. These double positive cells were also detected by confocal microscopy. Only around 50% of double positi...

journal_title：Immunology

authors： Kenny E,Mason D,Pombo A,Ramírez F

更新日期：2000-10-01 00:00:00