Fibronectin synthesis by activated T lymphocytes: up-regulation of a surface-associated isoform with signalling function.

abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...

journal_title：Immunology

authors： Ianaro A,O'Donnell CA,Di Rosa M,Liew FY

更新日期：1994-07-01 00:00:00

abstract：:Male and female spleen cells were compared before and after culture for their cytotoxicity to autologous-embryo fibroblasts. Cultures of male cells developed significantly greater reactivity than cultures of female cells. Moreover, while the cytotoxicity derived from cultures of male cells was totally abolished by tre...

journal_title：Immunology

authors： Gorczynski RM

更新日期：1976-10-01 00:00:00

abstract：:The IgG and IgA subclass distribution of anti-carbohydrate antibodies in normal and immunodeficient donors was investigated. In normal donors, the specific anti-dextran antibodies were mainly of the IgG2 and IgA2 subclass, although substantial amounts of antibodies could also be of the IgG1 subclass. In children, IgG1...

journal_title：Immunology

authors： Hammarström L,Persson MA,Smith CI

更新日期：1985-04-01 00:00:00

abstract：:Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

journal_title：Immunology

authors： Melgar S,Bas A,Hammarström S,Hammarström ML

更新日期：2002-08-01 00:00:00

abstract：:Immunopotentiation has been demonstrated when Klebsiella O3 lipopolysaccharide (KO3 LPS), which possesses a linear mannan as the O-specific side chain, was injected subcutaneously into endotoxin resistant C3H/HeJ mice together with soluble protein antigens. The LPS exhibited significantly positive adjuvant effects on ...

journal_title：Immunology

authors： Ohta M,Kido N,Nakashima I,Kato N

更新日期：1985-11-01 00:00:00

abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...

journal_title：Immunology

authors： Tamoto K,Koyama J

更新日期：1976-07-01 00:00:00

abstract：:Paratyphoid vaccine injected between 4 days and 3 hours before injection of labelled immune complexes (125-I-labelled BGG-anti-BGG), inhibits follicular trapping of these complexes in the mouse spleen. Inhibition is maximal when paratyphoid vaccine is given 1 day before, almost no label being found in the spleen folli...

journal_title：Immunology

authors： van Rooijen N

更新日期：1975-06-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:Plasma fibronectin (FN) has been demonstrated to serve as an opsonin involved in the ingestion of foreign particles by phagocytes. This study concerns the effect of FN exposure on the respiratory burst of normal human peripheral phagocytes, using a luminol-dependent chemiluminescence (CL) assay for measurement of reac...

journal_title：Immunology

authors： Kuroiwa A,Igisu K,Yano T,Okada N,Okada H

更新日期：1988-10-01 00:00:00

abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...

journal_title：Immunology

authors： Zhong W,Su W,Zhang Y,Liu Q,Wu J,Di C,Zhang Z,Xia Z

更新日期：2014-06-01 00:00:00

abstract：:A soluble form of Fc epsilon RII/CD23 is spontaneously released from most lymphoblastoid cell lines established by the Epstein-Barr virus (EBV). Such a product was purified on an IgE-Sepharose column and its pyrogenic effect was investigated in rabbits. This preparation induced a monophasic fever in rabbits, with a pe...

journal_title：Immunology

authors： Ghaderi AA,Stanworth DR

更新日期：1991-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibo...

journal_title：Immunology

authors： Kummu O,Turunen SP,Prus P,Lehtimäki J,Veneskoski M,Wang C,Hörkkö S

更新日期：2014-03-01 00:00:00

abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...

journal_title：Immunology

authors： Shindo T,Sugie K,Nakamura K,Tagaya Y,Maeda M,Uchiyama T,Sagawa K,Yokoyama M,Wada H,Hitomi S

更新日期：1990-09-01 00:00:00

abstract：:The B-cell development in a group of rats was suppressed for the first 45 days of life by serial administration of rabbit anti-rat IgM and IgD antibody. Total or near total suppression of B lymphopoiesis was achieved. At 45 days, suppression was stopped by injection of IgM and IgD rat paraproteins. The sequence of B-c...

journal_title：Immunology

authors： Bazin H,Platteau B,Maclennan IC,Johnson GD

更新日期：1985-01-01 00:00:00

abstract：:Antiserum specific for hamster thymus-derived lymphocytes, prepared by immunization of rabbits with brain tissue from MHA/ssLAK hamsters, was, in the presence of guinea-pig complement, cytotoxic to hamster thymocytes greater than lymph node cells greater than spleen cells, while virtually unreactive against bone marro...

journal_title：Immunology

authors： Blasecki JW,Houston KJ

更新日期：1978-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do...

journal_title：Immunology

authors： Khalili H,Deshpande R,Chang MY

更新日期：1997-12-01 00:00:00

abstract：:Gene ablation studies in mice indicate that lymphotoxin (LT)alpha, LTbeta and LTbetaR are essential for the genesis of lymph nodes (LN), normal structural development of peripheral lymphoid tissues and the differentiation of natural killer (NK) cells. LTbetaR binds to the heterotrimeric cytokines LTalpha1beta2 and LIG...

journal_title：Immunology

authors： Kather A,Chantakru S,He H,Minhas K,Foster R,Markert UR,Pfeffer K,Croy BA

更新日期：2003-03-01 00:00:00

abstract：:Two dermatophyte strains, Trichophyton quinckeanum and Trichophyton rubrum, were highly susceptible to in vitro killing by components of the H2O2-peroxidase-halide system. Both strains were, however, resistant to relatively high concentrations of reagent H2O2 or H2O2 enzymatically generated by glucose and glucose oxid...

journal_title：Immunology

authors： Calderon RA,Shennan GI

更新日期：1987-07-01 00:00:00

abstract：:Specific IgE and IgG responses to highly purified Ambrosia (ragweed) allergens, Amb a V, Amb t V and Amb p V from the artemisiifolia (short), trifida (giant) and psilostachya (western) species are strongly associated with HLA-DR2 and Dw2 (DR2.2) in allergic Caucasoid individuals. To investigate the molecular basis of ...

journal_title：Immunology

authors： Huang SK,Marsh DG

更新日期：1991-07-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-07-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...

journal_title：Immunology

authors： Ricciardelli I,Lindley KJ,Londei M,Quaratino S

更新日期：2008-10-01 00:00:00

abstract：:A serum factor, believed to be an IgG autoantibody, in certain patients with lepromatous leprosy inhibits the proliferation of mitogen-stimulated lymphocytes. To investigate which stage of the cell cycle was inhibited, we examined the effect of these sera on the kinetics of lymphocyte activation induced by several mit...

journal_title：Immunology

authors： Poulton TA,Gallagher A,Beck JS

更新日期：1989-11-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00

abstract：:Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...

journal_title：Immunology

authors： Giunti D,Parodi B,Cordano C,Uccelli A,Kerlero de Rosbo N

更新日期：2014-03-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Large doses of hydrocortisone, cyclophosphamide, and methotrexate injected subcutaneously, and whole-body irradiation (500 rads) caused a reduction in the number of peritoneal cells (PE cells) obtained after intraperitoneal injection of the treated mice with proteose-peptone. The same dose of cyclophosphamide and irra...

journal_title：Immunology

authors： Gadeberg OV,Rhodes JM,Larsen SO

更新日期：1975-01-01 00:00:00

abstract：:Canine cutaneous histiocytoma is a benign epidermal neoplasm of Langerhans cell origin, which usually displays spontaneous regression. Based on the degree of lymphocytic infiltration, 30 histiocytomas were classified into four groups representing different stages of tumour regression. To elucidate further the mechanis...

journal_title：Immunology

authors： Kaim U,Moritz A,Failing K,Baumgärtner W

更新日期：2006-08-01 00:00:00