Abstract：
:We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do express all known accessory molecules, intracellular adhesion molecule-1, B7 and major histocompatibility complex class II molecules. However, fetal macrophages do not express detectable invariant chain mRNA which is known to have a major role in the class II-associated antigen-processing pathway. Since fetal macrophages can neither present antigenic peptides nor superantigen, the diminished invariant chain expression alone cannot account for the impaired antigen-presenting function of fetal macrophages.
journal_name
Immunologyjournal_title
Immunologyauthors
Khalili H,Deshpande R,Chang MYdoi
10.1046/j.1365-2567.1997.00369.xsubject
Has Abstractpub_date
1997-12-01 00:00:00pages
487-93issue
4eissn
0019-2805issn
1365-2567journal_volume
92pub_type
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