Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids.

abstract：:The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...

journal_title：Immunology

authors： De Boer OJ,Horst E,Pals ST,Bos JD,Das PK

更新日期：1994-03-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) may play an important role in the control of human papillomavirus (HPV)-induced anogenital neoplasias, but have been difficult to study owing to the difficulty in obtaining sufficient quantities of infectious virus. To address this we have stimulated human HPV-specific CTL in vitro using ...

journal_title：Immunology

authors： Tarpey I,Stacey S,Hickling J,Birley HD,Renton A,McIndoe A,Davies DH

更新日期：1994-02-01 00:00:00

abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...

journal_title：Immunology

authors： Polson RJ,Jenkins R,Lombard M,Williams AC,Roberts S,Nouri-Aria K,Williams R,Bomford A

更新日期：1990-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:To assess the role of CD5 and CD28 in the pathogenesis of the decreased cellular immune function in patients with rheumatoid arthritis (RA) we analysed the expression and function of these T-cell surface molecules. The expression of CD5 as well as of CD28 in synovial and peripheral blood T cells was similar to that of...

journal_title：Immunology

authors： Verwilghen J,Corrigall V,Pope RM,Rodrigues R,Panayi GS

更新日期：1993-09-01 00:00:00

abstract：:Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb...

journal_title：Immunology

authors： Crane I,Leung H,Barwick S,Parti S,Meager A

更新日期：1984-12-01 00:00:00

abstract：:Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...

journal_title：Immunology

authors： Aho TL,Lund RJ,Ylikoski EK,Matikainen S,Lahesmaa R,Koskinen PJ

更新日期：2005-09-01 00:00:00

abstract：:Mutation of the interleukin-2 (IL-2) receptor gamma chain, which also serves as a component of the receptor complexes for IL-4, 7, 9 and 15, results in severe immune deficiency. We hypothesized that the immunological immaturity of healthy neonates might be associated with low levels of expression of this receptor mole...

journal_title：Immunology

authors： Zola H,Fusco M,Weedon H,Macardle PJ,Ridings J,Roberton DM

更新日期：1996-01-01 00:00:00

abstract：:A rat thymic epithelial cell (TEC) line (R-TNC.1) was established from a long-term TEC culture. Based on its ultrastructure, phenotype and cytokeratin profile, this line was characterized as a type of cortical TEC. R-TNC.1 cells had nursing activity which was manifested by the binding and subsequent engulfment of thym...

journal_title：Immunology

authors： Colić M,Vucević D,Miyasaka M,Tamatani T,Pavlović MD,Dujić A

更新日期：1994-11-01 00:00:00

abstract：:The CD3-T-cell receptor complex is the clonotypic surface structure by which T lymphocytes recognize foreign antigens and are subsequently activated. Because of the low immunogenicity of the CD3 molecules, anti-CD3 monoclonal antibodies (mAb) are difficult to prepare and have not been available in several species. Fol...

journal_title：Immunology

authors： Yang H,Oura CA,Kirkham PA,Parkhouse RM

更新日期：1996-08-01 00:00:00

abstract：:The specificities of antibodies raised in rabbits against rat mast cell proteinase 1 (RMCP 1) from connective tissue mast cells (CTMC), and against RMCP II from mucosal mast cells (MMC), were analysed by SDS-PAGE and Western blotting. Significant cross-reactivity was detected, and was eliminated by affinity purificati...

journal_title：Immunology

authors： Gibson S,Miller HR

更新日期：1986-05-01 00:00:00

abstract：:Compared with non-transgenic controls, mice bearing an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparabl...

journal_title：Immunology

authors： Nihrane A,Silver J

更新日期：1997-02-01 00:00:00

abstract：:The cloning and production of a human anti-rhesus (Rh) D monoclonal antibody (mAb) using the baculovirus-insect cell expression system is described. This monoclonal recombinant antibody R.D7C2 derived from a human parental IgM lambda immunoglobulin was obtained after immortalization of lymphocytes by Epstein-Barr viru...

journal_title：Immunology

authors： Edelman L,Margaritte C,Chaabihi H,Monchâtre E,Blanchard D,Cardona A,Morin F,Dumas G,Petres S,Kaczorek M

更新日期：1997-05-01 00:00:00

abstract：:The innate immune response provides the initial defence mechanism against infection by other organisms. However, an excessive immune response will cause damage to host tissues. In an attempt to identify microRNAs (miRNAs) that regulate the innate immune response in inflammation and homeostasis, we examined the differe...

journal_title：Immunology

authors： Niu Y,Mo D,Qin L,Wang C,Li A,Zhao X,Wang X,Xiao S,Wang Q,Xie Y,He Z,Cong P,Chen Y

更新日期：2011-05-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00

abstract：:Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune rea...

journal_title：Immunology

authors： Lens SM,Baars PA,Hooibrink B,van Oers MH,van Lier RA

更新日期：1997-01-01 00:00:00

abstract：:T-cell-mediated immunity to a virulent strain of Plasmodium berghei NK65 (Pb NK65) and to an attenuated derivative (Pb XAT) of the strain were examined in CBA mice by the administration of monoclonal antibodies against T-cell subsets or interferon-gamma (IFN-gamma). The injection of anti-CD8+ or anti-IFN-gamma delayed...

journal_title：Immunology

authors： Waki S,Uehara S,Kanbe K,Ono K,Suzuki M,Nariuchi H

更新日期：1992-04-01 00:00:00

abstract：:The addition of crude extracts from rat submandibular (SM) glands to murine spleen and lymph node cell cultures stimulated with concanavalin A (Con A) induced either suppression (at high concentrations) or further stimulation (at lower concentrations) or further stimulation (at lower concentrations) of proliferative a...

journal_title：Immunology

authors： Kemp A,Mellow L,Sabbadini E

更新日期：1985-10-01 00:00:00

abstract：:The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were a...

journal_title：Immunology

authors： Varga L,Thiry E,Füst G

更新日期：1988-07-01 00:00:00

abstract：:Signaling by Kit has been extensively studied in hematopoietic cells and is essential for the survival, proliferation and maintenance of hematopoietic stem and progenitor cells. In addition to the activation of intrinsic signaling pathways, Kit has been shown to interact with lineage-restricted type I cytokine recepto...

journal_title：Immunology

authors： Sethumadhavan A,Mani M

更新日期：2020-04-01 00:00:00

abstract：:Various strains of the murine mycoplasma M. neurolyticum have been shown to induce extensive blast transformation of mouse lymphocytes, comparable in strength to mitogenicity exerted by these mycoplasma species on rat lymphocytes. The data summarized in this report demonstrate that this mitogenic effect is non-specifi...

journal_title：Immunology

authors： Naot Y,Ginsburg H

更新日期：1978-04-01 00:00:00

abstract：:The influence of intact influenza virus and purified detergent solubilized haemagglutinin (HA) subunits from these viruses on human natural killer (NK) cell activity was examined. Effector cells incubated with whole influenza virus for 18 hr initiated the production of alpha interferon which was associated with the en...

journal_title：Immunology

authors： Ali SA,Rees RC,Oxford J

更新日期：1984-08-01 00:00:00

abstract：:Paratyphoid vaccine injected between 4 days and 3 hours before injection of labelled immune complexes (125-I-labelled BGG-anti-BGG), inhibits follicular trapping of these complexes in the mouse spleen. Inhibition is maximal when paratyphoid vaccine is given 1 day before, almost no label being found in the spleen folli...

journal_title：Immunology

authors： van Rooijen N

更新日期：1975-06-01 00:00:00

abstract：:Using KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex. IL-2R (p55), on several T-cell lines transf...

journal_title：Immunology

authors： Shindo T,Sugie K,Nakamura K,Tagaya Y,Maeda M,Uchiyama T,Sagawa K,Yokoyama M,Wada H,Hitomi S

更新日期：1990-09-01 00:00:00

abstract：:Class switch recombination (CSR) is a T-cell-dependent mechanism regulating isotype switching in activated mature B cells. Recently we showed that T-cell-independent CSRs occur spontaneously during B lymphopoiesis, but such cells are negatively selected by Fas signalling. In immunoglobulin mu-deficient mice, lack of F...

journal_title：Immunology

authors： Seagal J,Melamed D

更新日期：2004-06-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...

journal_title：Immunology

authors： Faris M,Kokot N,Stahl N,Nel AE

更新日期：1997-03-01 00:00:00

abstract：:Major histocompatibility complex (MHC) alleles acting as immune response genes are coexpressed in heterozygous individuals and therefore control of immune responses is usually codominant. As an exception to this rule, however, several examples of recessive immune responses have been ascribed to regulatory, e.g. suppre...

journal_title：Immunology

authors： Barcenas-Morales G,Merkenschlager M,Wahid F,Döffinger R,Ivanyi J

更新日期：2000-02-01 00:00:00

abstract：:Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...

journal_title：Immunology

authors： Huemer HP,Wang Y,Garred P,Koistinen V,Oppermann S

更新日期：1993-08-01 00:00:00

abstract：:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...

journal_title：Immunology

authors： Cantrell DA,Robins RA,Brooks CG,Baldwin RW

更新日期：1982-01-01 00:00:00