Phenotype of rat natural killer cells defined by monoclonal antibodies marking rat lymphocyte subsets.

Abstract:

:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK) activity in a quantifiable 6 hr 51Cr release assay. The data establish that rat natural killer cells are heterogeneous with respect to their surface antigen expression and that subpopulations of rat NK cells express the OX8 and W3/13 defined antigens. However, rat NK cells do not express the antigen defined by W3/24 monoclonal antibody.

journal_name

Immunology

journal_title

Immunology

authors

Cantrell DA,Robins RA,Brooks CG,Baldwin RW

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

97-103

issue

1

eissn

0019-2805

issn

1365-2567

journal_volume

45

pub_type

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