Abstract：
:Major histocompatibility complex (MHC) alleles acting as immune response genes are coexpressed in heterozygous individuals and therefore control of immune responses is usually codominant. As an exception to this rule, however, several examples of recessive immune responses have been ascribed to regulatory, e.g. suppressive, interactions. We report here that the recessive phenotype of both antibody and T-cell responses to the mycobacterial 16 000-MW antigen depends critically on a low antigen dose for immunization. On the basis of similar responses in hemi- and heterozygous mice, we suggest that the mechanism of recessive MHC control does not involve regulation by the low-responder allele. We also demonstrated mixed haplotype restriction of peptide recognition for a significant fraction of high-antigen-dose primed T cells. Their paucity under limiting antigen dose conditions may lead to the recessive expression of MHC control. In conclusion, our results suggest that recessive MHC control can be explained as a simple gene dosage effect under conditions where antigen is limiting, without a need for regulatory mechanisms.
journal_name
Immunologyjournal_title
Immunologyauthors
Barcenas-Morales G,Merkenschlager M,Wahid F,Döffinger R,Ivanyi Jdoi
10.1046/j.1365-2567.2000.00956.xkeywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
221-8issue
2eissn
0019-2805issn
1365-2567pii
imm956journal_volume
99pub_type
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