Abstract：
:CD248 (endosialin) is a transmembrane glycoprotein that is dynamically expressed on pericytes and fibroblasts during tissue development, tumour neovascularization and inflammation. Its role in tissue remodelling is associated with increased stromal cell proliferation and migration. We show that CD248 is also uniquely expressed by human, but not mouse (C57BL/6), CD8(+) naive T cells. CD248 is found only on CD8(+) CCR7(+) CD11a(low) naive T cells and on CD8 single-positive T cells in the thymus. Transfection of the CD248 negative T-cell line MOLT-4 with CD248 cDNA surprisingly reduced cell proliferation. Knock-down of CD248 on naive CD8 T cells increased cell proliferation. These data demonstrate opposing functions for CD248 on haematopoietic (CD8(+)) versus stromal cells and suggests that CD248 helps to maintain naive CD8(+) human T cells in a quiescent state.
journal_name
Immunologyjournal_title
Immunologyauthors
Hardie DL,Baldwin MJ,Naylor A,Haworth OJ,Hou TZ,Lax S,Curnow SJ,Willcox N,MacFadyen J,Isacke CM,Buckley CDdoi
10.1111/j.1365-2567.2011.03437.xsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
288-95issue
3eissn
0019-2805issn
1365-2567journal_volume
133pub_type
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