The effects of a soluble factor released by sensitized mononuclear cells incubated with S. haematobium ova on eosinophil migration.

abstract：:We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for Fc epsilon RI mRNA (alpha-, beta- and gamma-chains), the alpha-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions i...

journal_title：Immunology

authors： Ying S,Barata LT,Meng Q,Grant JA,Barkans J,Durham SR,Kay AB

更新日期：1998-02-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells). Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect. Delayed tre...

journal_title：Immunology

authors： MacPhee IA,Yagita H,Oliveira DB

更新日期：2006-03-01 00:00:00

abstract：:Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer (NK)-cell-mediated killing. This has been explained by either (1) the target interference model, or (2) the effector inhibition mod...

journal_title：Immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-09-01 00:00:00

abstract：:The nature of the Fc receptors for IgG subclasses displayed on the epithelium of the small intestine in neonatal rats was examined by comparing results gained from 125I-IgG binding studies using isolated enterocyte brush borders, and from experiments where in vivo transmission from the gut to the bloodstream was quant...

journal_title：Immunology

authors： Peppard JV,Jackson LE,Mackenzie NM

更新日期：1985-09-01 00:00:00

abstract：:We explored the mechanisms of class B CpG-oligodeoxynucleotide-induced antitumour effects against weakly immunogenic tumours. Treatment with CpG-oligodeoxynucleotide 1826 (CpG) induced similar antitumour effects in B16 melanoma-bearing immunocompetent C57BL/6 mice and T-cell-deficient severe combined immunodeficient (...

journal_title：Immunology

authors： Buhtoiarov IN,Sondel PM,Eickhoff JC,Rakhmilevich AL

更新日期：2007-03-01 00:00:00

abstract：:Different kinds of IgM antibodies were tested for their activity in antibody-dependent cellular cytotoxicity (ADCC): firstly an anti-benzylpenicilloyl (BPO) IgM antibody from immune rabbit serum purified by affinity, ion exchange, and molecular-sieving chromatography, secondly two monoclonal rat anti-BPO IgM antibodie...

journal_title：Immunology

authors： Rumpold H,Wiedermann G,Scheiner O,Kraft D,Stemberger H

更新日期：1981-05-01 00:00:00

abstract：:A murine anti-B monoclonal antibody was obtained by the hybridoma technique. This antibody called anti-B (b-183) is of IgM nature; it is capable of agglutinating normal B, B3, Bx, cis AB and some acquired B red cells. Its association constant is 1.1 X 10(8) l/mol, and appears high compared to those of the monoclonal a...

journal_title：Immunology

authors： Rouger P,Edelman L,Doinel C,Reviron J,Salmon C,Bach JF

更新日期：1983-05-01 00:00:00

abstract：:The kinetics of vascular leakage and tachyphylaxis induced by histamine and bradykinin were examined in rabbit skin and were compared with the kinetics of tachyphylaxis of neutrophil accumulation in lesions induced with the chemotaxin formylmethionyl-leucyl-phenylalanine (FMLP). Maximal leakage of 125I-human serum alb...

journal_title：Immunology

authors： Colditz IG

更新日期：1985-05-01 00:00:00

abstract：:We studied the immunoregulatory mechanisms of responsiveness and non-responsiveness to hepatitis B (HB) vaccine by analysing the influence of HB surface antigen (HBsAg) on lymphokine- or mitogen-stimulated peripheral lymphocytes from healthy volunteers. Stimulation with pokeweed mitogen (PWM) led to a reduced producti...

journal_title：Immunology

authors： Knöller I,Hoffmann UJ,Werchau HH,König W

更新日期：1990-11-01 00:00:00

abstract：:We have characterized two unusual T-cell hybridomas, 1E3 and 3B8, from H-2k mice immunized with I-Ab-transfected L cells (H-2k), that are stimulated by L cells transfected with I-Ab, I-Ak or I-Eb, but not by non-transfected L cells. These hybridomas could not be stimulated by spleen cells from H-2i3, H-2k, H-2b or H-2...

journal_title：Immunology

authors： Mendiratta SK,Singh N,Bal V,Rath S

更新日期：1996-10-01 00:00:00

abstract：:An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in ...

journal_title：Immunology

authors： Stark JM,Locke J,Heatley RV

更新日期：1980-03-01 00:00:00

abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...

journal_title：Immunology

authors： Tamoto K,Koyama J

更新日期：1976-07-01 00:00:00

abstract：:Antibodies against lymphocytes have been shown in human immunodeficiency virus (HIV)-infected patients, but their relevance in the pathogenesis of acquired immune deficiency syndrome (AIDS) remains controversial. We investigated increased levels of lymphocyte surface Ig and antibodies against CD4+ T cells in the plasm...

journal_title：Immunology

authors： Müller C,Kukel S,Bauer R

更新日期：1993-06-01 00:00:00

abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...

journal_title：Immunology

authors： Sabbele NR,Van Oudenaren A,Hooijkaas H,Benner R

更新日期：1987-10-01 00:00:00

abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...

journal_title：Immunology

authors： Costalonga M,Zell T

更新日期：2007-09-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:Neuropeptides can influence immune effector cell function at both systemic and mucosal immune sites. We examined the ability of substance P (SP) to modulate the natural killer (NK) activity of intestinal intraepithelial leucocytes (IEL). Yac-1 killing by IEL but not splenic cells was increased after either 18 hr prein...

journal_title：Immunology

authors： Croitoru K,Ernst PB,Bienenstock J,Padol I,Stanisz AM

更新日期：1990-10-01 00:00:00

abstract：:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...

journal_title：Immunology

authors： Cantrell DA,Robins RA,Brooks CG,Baldwin RW

更新日期：1982-01-01 00:00:00

abstract：:Mice exposed to paramyxovirus (Sendai) generate specifically sensitized thymus-derived lymphocytes (T cells) which, in an in vitro 51Cr release assay, interact only with virus-infected target cells sharing strong transplantation antigens. Reciprocal exclusion of cytotoxic T-cell activity is found for Sendai virus, lym...

journal_title：Immunology

authors： Doherty PC,Zinkernagel RM

更新日期：1976-07-01 00:00:00

abstract：:Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...

journal_title：Immunology

authors： Haubeck HD,Kölsch E

更新日期：1982-11-01 00:00:00

abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...

journal_title：Immunology

authors： Koizumi T,Nakao Y,Matsui T,Katakami Y,Mihara K,Takahashi R,Maeda S,Sugiyama T,Fujita T

更新日期：1988-05-01 00:00:00

abstract：:Gene transfer to create tumour epitope-specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart-127-35 -specific DMF5 T-cell receptor (TCR) is transferred into peripheral human CD4(+) T cells, the reprogrammed cells exhibit a T helper type 1 (Th1) phenotype with ...

journal_title：Immunology

authors： Jha SS,Chakraborty NG,Singh P,Mukherji B,Dorsky DI

更新日期：2015-05-01 00:00:00

abstract：:Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-07-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...

journal_title：Immunology

authors： Ray A,Dittel BN

更新日期：2015-11-01 00:00:00

abstract：:Eosinophil function is regulated by several cytokines, including interleukin-3 (IL-3), IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). Culture of human eosinophils with IL-3 produced a marked, dose-dependent up-regulation of CR3 expression. This was maximal after 1 day in culture and dependent on p...

journal_title：Immunology

authors： Hartnell A,Kay AB,Wardlaw AJ

更新日期：1992-12-01 00:00:00

abstract：:The defined antigen substrate spheres (DASS) system was employed for analysing reactions between solid state antibody or antigen and soluble immune complexes. Sepharose beads covalently coupled with ovalbumin were used to represent tumour cells and beads coupled with antibody against ovalbumin were used to represent a...

journal_title：Immunology

authors： Matthews N,de Kretser T,Nairn RC

更新日期：1975-06-01 00:00:00

abstract：:Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully demonstrated. In the present study, we found ...

journal_title：Immunology

authors： Park MH,Song MJ,Cho MC,Moon DC,Yoon DY,Han SB,Hong JT

更新日期：2012-01-01 00:00:00

abstract：:Protective CD4+ T cells against Mycobacterium bovis bacillus Calmette-Guérin (BCG), which are characterized by the ability to produce interferon-gamma (IFN-gamma), could be induced by immunization of mice with viable BCG but not with killed BCG. A high level of IFN-gamma mRNA was observed when normal spleen cells were...

journal_title：Immunology

authors： Yang J,Mitsuyama M

更新日期：1997-08-01 00:00:00

abstract：:Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...

journal_title：Immunology

authors： Mathy NL,Scheuer W,Lanzendörfer M,Honold K,Ambrosius D,Norley S,Kurth R

更新日期：2000-05-01 00:00:00