Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides.

abstract：:The Fas/Fas-ligand (FasL) system plays an important role in regulation of apoptosis and the immune response, and is exploited by mycobacteria to evade the immune response. This study was performed to investigate the distribution and levels of FasL and Fas in lymph node granulomas and sera of tuberculous lymphadenitis ...

journal_title：Immunology

authors： Mustafa T,Mogga SJ,Mfinanga SG,Mørkve O,Sviland L

更新日期：2005-02-01 00:00:00

abstract：:We have confirmed previous observations that intestinal anaphylaxis induced in rats previously sensitized to ovalbumin (OVA) is associated with an increased uptake of an unrelated 'bystander' protein, bovine serum albumin (BSA) fed 1 hr previously. In this study, this enhanced protein uptake was associated with an inc...

journal_title：Immunology

authors： Turner MW,Boulton P,Shields JG,Strobel S,Gibson S,Miller HR,Levinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...

journal_title：Immunology

authors： Kapasi K,Chui B,Inman RD

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to characterize the epitope specificity and the idiotype(s) of gp330-specific autoantibodies in active Heymann nephritis (HN). To study this, two monoclonal autoantibodies (mAb), 3D9B and 5B8C, derived from Lewis rats with HN, were generated. These antibodies bound to different epitopes on th...

journal_title：Immunology

authors： Specht Grijp-Glandorf RJ,De Heer E,Dekker-Nooren CC,Daha MR,Van Es LA

更新日期：1990-07-01 00:00:00

abstract：:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...

journal_title：Immunology

authors： Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DL

更新日期：1989-08-01 00:00:00

abstract：:The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...

journal_title：Immunology

authors： De Boer OJ,Horst E,Pals ST,Bos JD,Das PK

更新日期：1994-03-01 00:00:00

abstract：:Antigenic encounter by T cells induces immunological synapse formation and T-cell activation. Using different concentrations of toxic shock syndrome toxin-1 (TSST-1) as stimulus, we examined the capacities of dendritic cells (DC) and macrophages (Mphi) to prime syngeneic naive T cells. DCs were, under all experimental...

journal_title：Immunology

authors： Rothoeft T,Gonschorek A,Bartz H,Anhenn O,Schauer U

更新日期：2003-12-01 00:00:00

abstract：:Designing peptide-based vaccines for therapeutic applications in cancer immunotherapy requires detailed knowledge of the interactions between the antigenic peptide and major histocompatibility complex (MHC) in addition to that between the peptide-MHC complex and the T-cell receptor. Past efforts to immunize with high-...

journal_title：Immunology

authors： Lazoura E,Lodding J,Farrugia W,Ramsland PA,Stevens J,Wilson IA,Pietersz GA,Apostolopoulos V

更新日期：2006-11-01 00:00:00

abstract：:Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB-DM, TB or diabetes mellitus (DM), and in healthy contro...

journal_title：Immunology

authors： Kumar NP,Moideen K,Bhootra Y,Nancy A,Viswanathan V,Shruthi BS,Sivakumar S,Natarajan M,Kornfeld H,Babu S

更新日期：2019-03-01 00:00:00

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00

abstract：:Extracts produced from the seeds of Ulex europeus (European gorse) were found to contain an inhibitor of human and murine lymphocyte growth. Interference with lymphocyte growth was demonstrated in three test systems. (1) Ulex seed extracts (USE) prevented the uptake of tritiated thymidine by stimulated human T and B l...

journal_title：Immunology

authors： Pirofsky B,Beaulieu R,Davies GH

更新日期：1981-08-01 00:00:00

abstract：:The relationship between the IgA antibody response in serum (total and polymeric IgA) and intestinal secretions was examined in volunteers subjected to oral and parenteral typhoid vaccination. After oral vaccination (three doses of 10(11) live Ty21a vaccine given at 48-hr intervals), serum pIgA antibody to typhoid lip...

journal_title：Immunology

authors： Bartholomeusz RC,Forrest BD,Labrooy JT,Ey PL,Pyle D,Shearman DJ,Rowley D

更新日期：1990-02-01 00:00:00

abstract：:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...

journal_title：Immunology

authors： Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl K

更新日期：2020-12-01 00:00:00

abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...

journal_title：Immunology

authors： Niederkorn JY,Mayhew E

更新日期：1993-12-01 00:00:00

abstract：:The effect of invasive bacteria on the release of proinflammatory mediators (oxygen radicals, leukotriene release) from human polymorphonuclear neutrophils was studied. Bacterial stimuli were used including genetically cloned invasive Yersinia enterocolitica strains 108-P (bearing the phagocytosis-resistance plasmid) ...

journal_title：Immunology

authors： Gröne M,Scheffer J,König W

更新日期：1992-11-01 00:00:00

abstract：:Previously published work has shown that a cytotoxic T-cell epitope (CTL) representing residues 82-90 of the M2 protein of respiratory syncytial virus (RSV) is the target for a protective response against the virus. In this report, we demonstrate that a synthetic peptide representing residues 81-95, when covalently li...

journal_title：Immunology

authors： Hsu SC,Shaw DM,Steward MW

更新日期：1995-07-01 00:00:00

abstract：:We have developed a hybridoma cell line which secretes monoclonal antibody to human basement membrane type IV collagen. The monoclonal antibody secreted by this hybridoma has been obtained in large amounts by either concentrating it from culture supernatants or from the ascites fluid of mice bearing the hybridoma tumo...

journal_title：Immunology

authors： Sundarraj N,Willson J

更新日期：1982-09-01 00:00:00

abstract：:Many delayed-type reactions contain large infiltrates of basophils whose function is unknown. We have studied these cutaneous basophil hypersensitivity (CBH) reactions in guinea-pigs to ascertain whether basophils that are recruited to delayed reaction sites could be triggered for immediate reactivity. We compared 24 ...

journal_title：Immunology

authors： Askenase PW,Debernardo R,Tauben D,Kashgarian M

更新日期：1978-11-01 00:00:00

abstract：:Stimulation of human neutrophils (PMN) with Ca ionophore A23187, opsonized zymosan and formyl-L-methionyl-L-leucyl-phenylalanine (FMLP) led to a time- and dose-dependent release of LTB4, 20-OH-LTB4, 20-COOH-LTB4, 6-trans-LTB4, 12-epi-6-trans LTB4 and LTC4, as detected by reverse-phase HPLC. Preincubation of the PMN su...

journal_title：Immunology

authors： Raulf M,König W

更新日期：1988-05-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infecti...

journal_title：Immunology

authors： O'Keeffe J,Podbielska M,Hogan EL

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus ...

journal_title：Immunology

authors： Ishikawa N,Horii Y,Oinuma T,Suganuma T,Nawa Y

更新日期：1994-03-01 00:00:00

abstract：:Cholera toxin (CT) or its subunits were given orally to mice and division of intestinal intraepithelial lymphocytes (IEL) in vivo measured by double immunofluorescence using 5-bromo-2'-deoxyuridine (BRdU) and membrane alpha beta T-cell receptors (TCR) or gamma delta TCR staining in frozen sections. Cholera toxin (10 m...

journal_title：Immunology

authors： Penney I,Kilshaw PJ,MacDonald TT

更新日期：1996-09-01 00:00:00

abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...

journal_title：Immunology

authors： Langhans B,Braunschweiger I,Schweitzer S,Jung G,Inchauspé G,Sauerbruch T,Spengler U

更新日期：2001-04-01 00:00:00

abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...

journal_title：Immunology

authors： Rodrigues MF,Barsante MM,Alves CC,Souza MA,Ferreira AP,Amarante-Mendes GP,Teixeira HC

更新日期：2009-09-01 00:00:00

abstract：:Mycobacterium leprae-specific immunoglobulin G1 (IgG1) antibodies in patients with leprosy show a direct correlation with bacterial load (rho=0.748; P<0002) suggesting that IgG1 B-cell responses may be surrogate markers of disease progression. To investigate if this upregulation was a general feature of IgG1 responses...

journal_title：Immunology

authors： Hussain R,Dockrell HM,Chiang TJ

更新日期：1999-04-01 00:00:00

abstract：:Sodium penicillin was conjugated to sheep erythrocytes and optimal quantities, added to a 5% SRBC suspension, were determined for haemagglutination (12-5 mg/ml) and for haemolysis (50 mg/ml) using carp antibodies and carp complement. The epitope density on the BSA molecule was gradually increased, when increasing amou...

journal_title：Immunology

authors： Avtalion RR,Milgrom L

更新日期：1976-10-01 00:00:00

abstract：:Human haematopoietic progenitor/stem cells (HPCs) differentiate into functional T cells in the thymus through a series of checkpoints. A convenient in vitro system will greatly facilitate the understanding of T-cell development and future engineering of therapeutic T cells. In this report, we established a lentiviral ...

journal_title：Immunology

authors： Patel E,Wang B,Lien L,Wang Y,Yang LJ,Moreb JS,Chang LJ

更新日期：2009-09-01 00:00:00

abstract：:In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically to...

journal_title：Immunology

authors： Kamada N,Shinomiya T

更新日期：1985-05-01 00:00:00

abstract：:DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When i...

journal_title：Immunology

authors： Casellas R,Yamane A,Kovalchuk AL,Potter M

更新日期：2009-03-01 00:00:00

abstract：:Humans and other mammals coexist with a diverse array of microbes colonizing the intestine, termed the microflora. The relationship is symbiotic, with the microbes benefiting from a stable environment and nutrient supply, and the host gaining competitive exclusion of pathogens and continuously maintenance of the gut i...

journal_title：Immunology

authors： Zeuthen LH,Fink LN,Frokiaer H

更新日期：2008-02-01 00:00:00