'Subthreshold stimulation' of allospecific delayed hypersensitivity by corneal allografts.

abstract：:During acute Trypanosoma cruzi infection in mice, many leucocytes undergo apoptosis. Although apoptosis has been ascribed to increased levels of nitric oxide (NO) and Fas-FasL interaction, the importance of this phenomenon in modulating the host response against T. cruzi is unknown. Herein, the role of NO- and Fas-Fas...

journal_title：Immunology

authors： Martins GA,Petkova SB,MacHado FS,Kitsis RN,Weiss LM,Wittner M,Tanowitz HB,Silva JS

更新日期：2001-05-01 00:00:00

abstract：:Drug abuse is a global problem of considerable concern to health. One such health concern stems from the fact that many drugs of abuse have immunosuppressive actions and consequently have the potential to increase susceptibility to infectious disease. This article is focused on the impact of the amphetamine derivative...

journal_title：Immunology

authors： Connor TJ

更新日期：2004-04-01 00:00:00

abstract：:The pathology of the spleen, lymph nodes and thymus of C57L/J mice, infected intraperitoneally with 20 and 100 cysts of Echinococcus multilocularis is described at 2, 4, 8 and 12 weeks postinfection (p.i.). For the first 8 weeks, growth of the larval cyst mass (LCM) was slow and blastogenesis in T-dependent areas of b...

journal_title：Immunology

authors： Ali-Khan Z

更新日期：1978-05-01 00:00:00

abstract：:T helper type 17 (Th17) cells and regulatory T (Treg) cells are two distinct T-cell subsets with opposite effects on immune functions. While Th17 cells are a key effector in the immune response and play critical roles in the development of autoimmunity and inflammation, Treg cells orchestrate the overall immune respon...

journal_title：Immunology

authors： Liu C,Yang H,Shi W,Wang T,Ruan Q

更新日期：2018-12-01 00:00:00

abstract：:When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical...

journal_title：Immunology

authors： Marchal G,Milon G,Guénet JL

更新日期：1980-02-01 00:00:00

abstract：:The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with ...

journal_title：Immunology

authors： Lowy I,Bona C,Ciorbaru R,Chedid L

更新日期：1977-06-01 00:00:00

abstract：:Dendritic cells (DC) are powerful inducers of primary T-cell responses, but their role in secondary responses has not been extensively analysed. Here, we address the role of two DC subsets derived from human CD16(+) (16(+) mDC) or CD16(-) (16(-) mDC) monocytes on the reactivation of memory responses. CD4(+) CD45RA(-) ...

journal_title：Immunology

authors： Bajaña S,Herrera-González N,Narváez J,Torres-Aguilar H,Rivas-Carvalho A,Aguilar SR,Sánchez-Torres C

更新日期：2007-11-01 00:00:00

abstract：:Adoptive transfer of T-cells is a promising therapy for many cancers. To enhance tumour recognition by T-cells, chimeric antigen receptors (CARs) consisting of signalling domains fused to receptors that recognize tumour-associated antigens can be expressed in T-cells. While CAR T-cells have shown clinical success for ...

journal_title：Immunology

authors： Parriott G,Deal K,Crean S,Richardson E,Nylen E,Barber A

更新日期：2020-07-01 00:00:00

abstract：:In mice, the plasma cell (PC) niche in the bone marrow is close to the haematopoietic stem cell (HSC) niche. We investigated whether PCs can be mobilized into the peripheral blood (PB) in healthy donors receiving granulocyte colony-stimulating factor (G-CSF) for the induction of HSC mobilization into the PB. G-CSF inc...

journal_title：Immunology

authors： Caraux A,Perez-Andres M,Larroque M,Requirand G,Lu ZY,Kanouni T,Rossi JF,Orfao A,Klein B

更新日期：2011-02-01 00:00:00

abstract：:Osteopontin (OPN) is a secreted phosphoprotein found in body fluids (e.g. plasma, urine, milk) and in mineralized tissues. Its expression is increased in many transformed cells and in normal cells exposed to various cytokines. When stimulated with the inflammatory mediators lipopolysaccharide and interferon-gamma, mou...

journal_title：Immunology

authors： Rollo EE,Denhardt DT

更新日期：1996-08-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Although interleukin-21 (IL-21) potently activates and controls the differentiation of immune cells after stimulation in vitro, the role for this pleiotropic cytokine during in vivo infection remains poorly defined. Herein, the requirement for IL-21 in innate and adaptive host defence after Listeria monocytogenes infe...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Rowe JH,Way SS

更新日期：2010-10-01 00:00:00

abstract：:Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic ...

journal_title：Immunology

authors： Ravindran R,McSorley SJ

更新日期：2005-04-01 00:00:00

abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

journal_title：Immunology

authors： Brandtzaeg P

更新日期：1975-09-01 00:00:00

abstract：:Non-obese diabetic (NOD) mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) as a consequence of autoimmune aggression of beta cells of the endocrine pancreas by T cells. T lymphocytes of NOD mice are resistant to apoptosis induced by glucocorticoids, or by starving or DNA-damaging treatments, a feat...

journal_title：Immunology

authors： Martins TC,Aguas AP

更新日期：1998-11-01 00:00:00

abstract：:In order to examine the mechanism of specific immunity in the lung, the distribution of Ia antigens and T lymphocyte populations was determined using immunoperoxidase-staining of cryostat sections of lungs from specific pathogen-free rats. BALT was found to be divided into three regions of lymphoid tissue. The central...

journal_title：Immunology

authors： Simecka JW,Davis JK,Cassell GH

更新日期：1986-01-01 00:00:00

abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...

journal_title：Immunology

authors： Zevering Y,Khamboonruang C,Good MF

更新日期：1998-07-01 00:00:00

abstract：:Chloroquine treatment of antigen-presenting cells (APC) was explored as a tool to investigate the processing pathway for major histocompatibility complex (MHC) class II-restricted presentation of the endogenous secreted hen egg lysozyme (HEL) and transmembrane measles virus haemagglutinin (HA). A 72-hr pretreatment of...

journal_title：Immunology

authors： Lombard-Platlet S,Bertolino P,Deng H,Gerlier D,Rabourdin-Combe C

更新日期：1993-12-01 00:00:00

abstract：:The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditions which regulate the death pathway under normal circumstances are s...

journal_title：Immunology

authors： Walker LS,McLeod JD,Boulougouris G,Patel YI,Ellwood CN,Hall ND,Sansom DM

更新日期：1999-12-01 00:00:00

abstract：:An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. maj...

journal_title：Immunology

authors： Sakai T,Hisaeda H,Nakano Y,Ishikawa H,Maekawa Y,Ishii K,Nitta Y,Miyazaki J,Himeno K

更新日期：2000-04-01 00:00:00

abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...

journal_title：Immunology

authors： Sanderson CJ,Strath M

更新日期：1985-02-01 00:00:00

abstract：:The properties of IgA and IgG anti-gliadin antibodies from the serum of patients with coeliac disease have been compared. The antibodies were quantified by ELISA using microtitre plates coated with crude gliadin fractions. Their specificity was confirmed by immunoblotting. Heat-treated sera containing IgA antibodies s...

journal_title：Immunology

authors： Stewart WW,Kerr MA

更新日期：1991-08-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:To further investigate the immunomodulatory effects of dietary lipids, rats were fed on a low-fat diet or on high-fat diets that contained hydrogenated coconut, olive, safflower, evening primrose or fish oil as the principal fat source. The fish oil diet decreased the level of expression of CD2, CD11a, CD18 and CD44 o...

journal_title：Immunology

authors： Sanderson P,Calder PC

更新日期：1998-05-01 00:00:00

abstract：:Injection of heat-killed Escherichia coli into rats results in massive loss of IgM + ve, IgD - ve B cells from the marginal zones of their spleen within 4 hr. This is matched by a concomitant increase of cells with this phenotype in the splenic follicles. The marginal zone remains depleted and the follicles distended ...

journal_title：Immunology

authors： Gray D,Kumararatne DS,Lortan J,Khan M,MacLennan IC

更新日期：1984-08-01 00:00:00

abstract：:With an increase in the importance of umbilical cord blood (CB) as an alternative source of haematopoietic progenitors for allogenic transplantation, donor lymphocyte infusion (DLI) with donor CB-derived activated CD4(+) T cells in the unrelated CB transplantation setting is expected to be of increased usefulness as a...

journal_title：Immunology

authors： Miyagawa Y,Kiyokawa N,Ochiai N,Imadome K,Horiuchi Y,Onda K,Yajima M,Nakamura H,Katagiri YU,Okita H,Morio T,Shimizu N,Fujimoto J,Fujiwara S

更新日期：2009-11-01 00:00:00

abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...

journal_title：Immunology

authors： Bodhankar S,Vandenbark AA,Offner H

更新日期：2012-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of th...

journal_title：Immunology

authors： Crotzer VL,Glosson N,Zhou D,Nishino I,Blum JS

更新日期：2010-11-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...

journal_title：Immunology

authors： Kudo F,Ikutani M,Seki Y,Otsubo T,Kawamura YI,Dohi T,Oshima K,Hattori M,Nakae S,Takatsu K,Takaki S

更新日期：2016-01-01 00:00:00

abstract：:Differences in the in vivo net growth rate of Salmonella typhimurium C5 during the first week of infection in different mouse strains are controlled by a single autosomal gene. In lethally irradiated mice repopulated with semi-allogeneic bone marrow, the early net growth rate shows the phenotype of the donor of the bo...

journal_title：Immunology

authors： Hormaeche CE

更新日期：1979-06-01 00:00:00