Abstract：
:When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical in +/+ and Wf/Wf primed mice. At site of local transfer of +/+ sensitized cells and antigen, the recruitment of monocytes was identical in +/+ and Wf/Wf mice. In contrast, the number of blood cells able to transfer a DTH reaction was decreased by a factor 40 in Wf/Wf primed mice compared to +/+ ones. This decreased number of sensitized cells in blood of Wf/Wf mice revealed a specific defective circulation of Wf/Wf DTH mediating cells whatever the genotypes (+/+ or Wf/Wf) of recipients used to measure this property of circulation.
journal_name
Immunologyjournal_title
Immunologyauthors
Marchal G,Milon G,Guénet JLsubject
Has Abstractpub_date
1980-02-01 00:00:00pages
269-74issue
2eissn
0019-2805issn
1365-2567journal_volume
39pub_type
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