The immunology of experimental liver transplantation in the rat.

abstract：:Goats were immunized with membrane fractions of the L5178Y tumour syngenic to DBA/2 mice. IgG fractions of this antiserum were made tumour specific by repeated in vitro and in vivo absorptions with normal cells and concentrated by adsorption to and elution from tumour cells. In vivo studies indicated that the accumula...

journal_title：Immunology

authors： Froese G,Berczi I,Israels LG

更新日期：1982-02-01 00:00:00

abstract：:The biological effects of three thymosin fraction 5 polypeptides, designated as beta 10, beta 4, and alpha 1 were tested in the MLR of mouse splenocytes, lymph node cells and thymocytes against syngeneic or allogeneic stimulators. It was found that all three polypeptides, after in vivo and in vitro treatment of the re...

journal_title：Immunology

authors： Baxevanis CN,Perez S,Kokkinopoulos D,Papamichail M

更新日期：1985-04-01 00:00:00

abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...

journal_title：Immunology

authors： Walker W,Rotondo D

更新日期：2004-03-01 00:00:00

abstract：:The human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain comprises at least four polypeptides. One of these is expressed as a membrane-bound subunit and has been designated as CD74. We investigated the expression of CD74 on B- and T-cell types utilizing monoclonal antibodies (mAb) speci...

journal_title：Immunology

authors： Wilson KM,Labeta MO,Pawelec G,Fernandez N

更新日期：1993-06-01 00:00:00

abstract：:CD40/CD154 interaction is essential for both humoral and cellular immune response. We investigated whether this interaction could be altered in patients with kidney failure who are known to present an impaired immune response. To that aim, we measured the levels of the soluble form of CD40 (sCD40), which is known to i...

journal_title：Immunology

authors： Contin C,Pitard V,Delmas Y,Pelletier N,Defrance T,Moreau JF,Merville P,Déchanet-Merville J

更新日期：2003-09-01 00:00:00

abstract：:Marginal zone (MZ) B cells are positioned within the spleen to capture blood-borne antigen and immune complexes and deliver them to follicular dendritic cells in the B-cell follicles. We show that within the spleens of aged mice antigen capture by MZ B cells, and their ability to shuttle between the follicle and MZ, w...

journal_title：Immunology

authors： Turner VM,Mabbott NA

更新日期：2017-07-01 00:00:00

abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...

journal_title：Immunology

authors： Zevering Y,Khamboonruang C,Good MF

更新日期：1998-07-01 00:00:00

abstract：:This study reports the expression and functional characterization of the rat analogue of the human complement regulatory molecule CD59. We here describe the expression in chinese hamster ovary (CHO) cells of rat CD59 and a modified rat CD59 in which an N-glycosylation site at Asn-16 has been deleted by point mutation....

journal_title：Immunology

authors： Rushmere NK,Tomlinson S,Morgan BP

更新日期：1997-04-01 00:00:00

abstract：:The cloning and production of a human anti-rhesus (Rh) D monoclonal antibody (mAb) using the baculovirus-insect cell expression system is described. This monoclonal recombinant antibody R.D7C2 derived from a human parental IgM lambda immunoglobulin was obtained after immortalization of lymphocytes by Epstein-Barr viru...

journal_title：Immunology

authors： Edelman L,Margaritte C,Chaabihi H,Monchâtre E,Blanchard D,Cardona A,Morin F,Dumas G,Petres S,Kaczorek M

更新日期：1997-05-01 00:00:00

abstract：:The chemokine receptor CCR7 is crucial for migration of mature dendritic cells (DC) directed toward secondary lymphoid organs; however, there is little knowledge about the function of the homeostatic chemokine receptor CXCR4 in DC and its contribution to directional migration of DC during inflammation. By comparing th...

journal_title：Immunology

authors： Humrich JY,Humrich JH,Averbeck M,Thumann P,Termeer C,Kämpgen E,Schuler G,Jenne L

更新日期：2006-02-01 00:00:00

abstract：:Lipoprotein was isolated from tumour cells by sonication and ultracentrifugal flotation on KBr gradients. It contained H-2 antigen detectable by antibody binding and induced a primary or secondary cell-mediated cytotoxic response in vitro which was H-2 specific. In a syngeneic model only a secondary cell-mediated resp...

journal_title：Immunology

authors： Dennert G

更新日期：1979-12-01 00:00:00

abstract：:Rapid expulsion of the nematode Trichinella spiralis from immune rats is associated with an increase in volume of intestinal exudate and the presence of large numbers of tissue mucosal mast cells (MMC) and eosinophils. We have measured the concentrations of leukotrienes (LT) C4 (LTC4) and B4 (LTB4) in gut perfusates a...

journal_title：Immunology

authors： Moqbel R,Wakelin D,MacDonald AJ,King SJ,Grencis RK,Kay AB

更新日期：1987-03-01 00:00:00

abstract：:Gammadelta T cells are unique, and their localization at sites of infection is considered critical in immune defence. We demonstrate the accumulation of gammadelta T cells in rat regional popliteal lymph nodes (PLNi) starting 2 days after inoculation of cytomegalovirus (CMV) into the footpad. Early-appearance PLNi gam...

journal_title：Immunology

authors： Dyugovskaya L,Hirsh M,Ginsburg H

更新日期：2003-02-01 00:00:00

abstract：:The immunoglobulin content of porcine nasal, tracheal and bronchio-alveolar secretions was determined. IgA was the predominant immunoglobulin in nasal and tracheal secretions, there being no significant difference (P greater than 0.01) between their IgA:IgG ratios of 2.7:1 and 2.4:1, respectively. In contrast, IgG was...

journal_title：Immunology

authors： Morgan KL,Hussein AM,Newby TJ,Bourne FJ

更新日期：1980-11-01 00:00:00

abstract：:Several cloned, non-leukaemic mouse haemopoietic cell lines are believed to be uniquely dependent on interleukin-3 (IL-3) for their survival. All of these lines require the addition of WEHI-3B cell-conditioned medium for their growth. We have examined the growth requirements of four IL-3-dependent cell lines and found...

journal_title：Immunology

authors： Carron JA,Marshall-Clarke S

更新日期：1986-08-01 00:00:00

abstract：:CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and...

journal_title：Immunology

authors： Piercy J,Petrova S,Tchilian EZ,Beverley PC

更新日期：2006-06-01 00:00:00

abstract：:A subpopulation of human peripheral blood natural killer (NK) cells, defined by sedimentation at Percoll high buoyant densities (P greater than 1.0635-1.0640 g/ml) and unresponsiveness to interleukin-2 (IL-2), contained two distinct populations based on the intensity of CD16 (FcR gamma III) expression, namely CD16dim ...

journal_title：Immunology

authors： Warren HS,Skipsey LJ

更新日期：1991-01-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...

journal_title：Immunology

authors： Rückert R,Brandt K,Ernst M,Marienfeld K,Csernok E,Metzler C,Budagian V,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2009-01-01 00:00:00

abstract：:Dogs with immunoglobulin E (IgE) allergy for ragweed that are sensitized by intrapulmonary exposure to ragweed can be used to study the pulmonary immune response that is important in allergic asthma. Using this model, we tested the hypothesis that T lymphocytes are activated locally in the airways shortly after allerg...

journal_title：Immunology

authors： Out TA,Wang SZ,Rudolph K,Bice DE

更新日期：2002-04-01 00:00:00

abstract：:A fully humanized anti-CD4 antibody was studied for its effects on resting and activated CD4 T cells. Whereas the antibody was poorly lytic, it induced dramatic down-modulation of CD4 expression on both types of cell. In order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for Fc...

journal_title：Immunology

authors： Bartholomew M,Brett S,Barber K,Rossman C,Crowe S,Tite J

更新日期：1995-05-01 00:00:00

abstract：:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the contr...

journal_title：Immunology

authors： Devey ME,Bleasdale KM,French MA,Harrison G

更新日期：1985-07-01 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:To date, the most potent mucosal vaccine adjuvants to be identified have been bacterial toxins. The present data demonstrate that the type 2 ribosome-inactivating protein (type 2 RIP), mistletoe lectin I (ML-I) is a strong mucosal adjuvant of plant origin. A number of plant lectins were investigated as intranasal (i.n...

journal_title：Immunology

authors： Lavelle EC,Grant G,Pusztai A,Pfüller U,O'Hagan DT

更新日期：2001-01-01 00:00:00

abstract：:The influence of the thymus and the possible requirement for surface immunoglobulin expression for the development of K and NK activity were assessed in rats. This species was chosen in preference to mice as they show good levels of K-cell activity. Studies were carried out in athymic (rnu/rnu) rats some of which were...

journal_title：Immunology

authors： Chassoux D,Kolb JP,Bazin H,MacLennan IC

更新日期：1983-11-01 00:00:00

abstract：:Canine cutaneous histiocytoma is a benign epidermal neoplasm of Langerhans cell origin, which usually displays spontaneous regression. Based on the degree of lymphocytic infiltration, 30 histiocytomas were classified into four groups representing different stages of tumour regression. To elucidate further the mechanis...

journal_title：Immunology

authors： Kaim U,Moritz A,Failing K,Baumgärtner W

更新日期：2006-08-01 00:00:00

abstract：:It is believed that self-reactive forbidden T-cell clones are generated by 'failure' of the pathway of T-cell differentiation in the thymus, if it is disturbed. We examined how such forbidden clones are generated under immunosuppressive conditions. Mice were treated with an injection of deoxyspergualin, FK506, or cycl...

journal_title：Immunology

authors： Moroda T,Kawachi Y,Iiai T,Tsukahara A,Suzuki S,Tada T,Watanabe H,Hatakeyama K,Abo T

更新日期：1997-05-01 00:00:00

abstract：:A suppressive B-cell factor (SBF)-producing hybridoma termed TS-4.44 was established by fusion of B cells which possessed receptors for the Fc portion of IgG (FcR gamma + B cells) and thymidine kinase defective fibroblasts, 3T3-4E cells. The biological properties of hybridoma-produced SBF (Hyb-SBF) are almost the same...

journal_title：Immunology

authors： Suzuki T,Miyama-Inaba M,Masuda T,Uchino H,Ishii K

更新日期：1983-12-01 00:00:00

abstract：:Intestinal inflammatory disease or infection often results in the loss of the epithelial layer as a result mainly of the action of proteases, including the leucocyte serine proteinases (neutrophil elastase), lysosomal cathepsins and the matrix metalloproteinases from recruited inflammatory cells. Previous studies have...

journal_title：Immunology

authors： Miller TL,McGee DW

更新日期：2002-01-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...

journal_title：Immunology

authors： Delgoffe GM,Powell JD

更新日期：2009-08-01 00:00:00