Abstract：
:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the controls compared to the patients, the differences were not significant. Most individuals (65%) produced antibody of the IgG1 subclass with little or no IgG4 antibody, but in the remainder antibody was either predominantly IgG4 (29%) or equally distributed between the IgG1 and IgG4 subclasses (6%). Antibody affinity was significantly lower in both patients and controls producing IgG4 antibodies compared to those with a predominantly IgG1 response, and antibody affinity increased with the amount of IgG1 antibody present. These results provide preliminary evidence of an association between low antibody affinity and the IgG4 subclass in man.
journal_name
Immunologyjournal_title
Immunologyauthors
Devey ME,Bleasdale KM,French MA,Harrison Gsubject
Has Abstractpub_date
1985-07-01 00:00:00pages
565-7issue
3eissn
0019-2805issn
1365-2567journal_volume
55pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied t...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2567.1997.00325.x
更新日期：1997-09-01 00:00:00
abstract：:Free malarial merozoites isolated from in vitro cultures of P. knowlesi and emulsified with Freund's complete (FCA) or incomplete (FIA) adjuvant were used to vaccinate twelve Rhesus monkeys against the uniformly lethal infection caused by P. knowlesi. Initial challenge of six monkeys with the same parasite variant as ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to maintain immunotolerance and suppress the antigen-specific or antigen-non-specific T-cell responses, but their role in chronic hepatitis B (CHB) infection in humans has not been well characterized. In this study, we analysed the frequency and ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02691.x
更新日期：2008-01-01 00:00:00
abstract：:The effect of disodium cromoglycate (DSCG) upon human immunoglobulin (Ig) isotypes and IgG subclasses production by purified B cells was studied. DSCG enhanced IgM, IgG1, IgG2, IgG3, IgG4 and IgA production in a dose-dependent fashion, while DSCG failed to induce IgE production at any concentrations tested by purified...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Spleen lymphocytes from C4-deficient (C4D) and Albany strains of guinea-pigs, 1-7 days, 3-6 and 12-16 months old, genetically related to inbred strains 13 and 2 respectively, were analysed in terms of their expression of cell surface markers, allogenic and T- and B-cell mitogenic responses, and interleukin-1 (IL-1) an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:The pathology of the spleen, lymph nodes and thymus of C57L/J mice, infected intraperitoneally with 20 and 100 cysts of Echinococcus multilocularis is described at 2, 4, 8 and 12 weeks postinfection (p.i.). For the first 8 weeks, growth of the larval cyst mass (LCM) was slow and blastogenesis in T-dependent areas of b...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：:Interleukin-3 activity is produced by T cells at an early phase after antigenic stimulation, and its quantitation provides a sensitive and non-destructive method for assaying T-cell activation. It can be detected before increased uptake of [3H]thymidine into DNA occurs, and is more sensitive than measuring [3H]thymidi...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03194.x
更新日期：2010-03-01 00:00:00
abstract：:We have developed a thyroglobulin-specific haemolytic plaque assay and investigated potential sites of autoantibody synthesis in good and poor responder strains of rats immunized with thyroglobulin and in rats subjected to thymectomy and sub-lethal irradiation which subsequently develop thyroiditis spontaneously. The ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2002.01526.x
更新日期：2002-12-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12350
更新日期：2014-12-01 00:00:00
abstract：:The role of the monocyte in human cytomegalovirus (HCMV)-induced immunosuppression was examined by assessing the ability of the virus to directly suppress various monocyte accessory cell functions. Both patient-derived and laboratory-adapted strains of HCMV were capable of impairing antigen-presenting functions of pur...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02763.x
更新日期：2008-06-01 00:00:00
abstract：:Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2005.02140.x
更新日期：2005-04-01 00:00:00
abstract：:The activation of guinea-pig eosinophils was studied by measuring the production of superoxide anion (O2-) and the secretion of eosinophil peroxidase (EPO). Phorbol myristate acetate (PMA), calcium ionophore, plasma-activated zymosan, concanavalin A and recombinant human anaphylatoxin C5a induced the release of varyin...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immu...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03069.x
更新日期：2009-05-01 00:00:00
abstract：:Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), enables antigen recognition and mediates appropriate immune responses. Distinct subsets of human DCs have been...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12252
更新日期：2014-06-01 00:00:00
abstract：:The Ager assay was adapted to a porcine lymphocyte-rat high endothelial cell (HEC) system. Using this in vitro assay, the role of porcine CD44 in lymphocyte binding to HEC was examined. The results show that the presence of soluble CD44 molecules did not inhibit the binding of porcine lymphocytes to the cultured rat H...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:Release of immunoglobulin-binding factors was induced from cultured human lymphoblastoid cells in a serum-free environment by incubation at 37 degrees. RPMI-8866 cells expressing Fc receptors for IgE (Fc epsilon R) and Daudi cells expressing Fc receptors for IgG (Fc gamma R) released IgE- and IgG-binding factors, resp...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Isolated normal human peripheral neutrophils became cytotoxic to chicken red blood cells (CRBC) in the presence of phytohaemagglutinin (PHA) and concanavalin A (Con A), a phenomenon which we have termed lectin-dependent neutrophilmediated cytotoxicity (LDNMC). Substantial cytotoxicity could be demonstrated by 1 h of i...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：:After a primary infection of congenitally athymic nu/nu mice with Strongyloides ratti, worms were not expelled and the number of intestinal mucosal mast cells (MMC) remained at a low level. When S. ratti-infected nu/nu mice were treated by repetitive injections of semi-purified IL-3 from Day 5 to Day 10 post-infection...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.13232
更新日期：2020-09-01 00:00:00
abstract：:Immunoregulatory CD4(-) CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12064
更新日期：2013-05-01 00:00:00
abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12234
更新日期：2014-05-01 00:00:00
abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer (NK)-cell-mediated killing. This has been explained by either (1) the target interference model, or (2) the effector inhibition mod...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
