Abstract：
:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the allografted rabbit stimulated with cells from the allograft donor occurred on days 3 to 4 of culture and by day 6 the MLR response was down to control levels. This accelerated response by the allograft-sensitized cells was specific to stimulator cells from the allograft donor as stimulator cells from a third party rabbit induced a normal MLR response by these cells, that is, an optimal response on days 5 to 7 of culture. No evidence of cytotoxic cells was obtained in cultures of cells from allograft-sensitized rabbits. The implications of these results are discussed.
journal_name
Immunologyjournal_title
Immunologyauthors
Milthorp P,Belanger R,Richter Mkeywords:
subject
Has Abstractpub_date
1979-01-01 00:00:00pages
25-31issue
1eissn
0019-2805issn
1365-2567journal_volume
36pub_type
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