The influence of cyclophosphamide and 6-mercaptopurine on the IgG1 and IgG2 immune response in guinea-pigs.

abstract：:This study examines the expression of mRNA for the Th2 cytokine, interleukin-4 (IL-4). Peripheral blood mononuclear cells from deer infected with Mycobacterium bovis or vaccinated with live or killed M. bovis bacillus Calmette-Guérin (BCG) were cultured with mycobacterial antigens. IL-4 mRNA production was assayed usi...

journal_title：Immunology

authors： Hook S,Griffin F,Mackintosh C,Buchan G

更新日期：1996-06-01 00:00:00

abstract：:Thymocytes expressing self-reactive T-cell receptors (TCR) are eliminated in the thymus through a TCR-mediated signal. This cell death signal (negative selection) generates nuclear morphological change and DNA fragmentation in thymocytes. However, the pathway leading to DNA fragmentation of thymocytes following TCR en...

journal_title：Immunology

authors： Nagata T,Kishi H,Liu QL,Matsuda T,Imanaka T,Tsukada K,Kang D,Muraguchi A

更新日期：2002-04-01 00:00:00

abstract：:Contact sensitization by epicutaneous application of picryl chloride causes in mice a significant reduction of the antibody responses to immunogenic TNP-conjugates. This split unresponsiveness is along-lasting. It was found that hapten applied on the skin became attached to the serum proteins and the transfer of such ...

journal_title：Immunology

authors： Rózycka D,Ptak W

更新日期：1978-08-01 00:00:00

abstract：:Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...

journal_title：Immunology

authors： Asherson GL,Mayhew B,Perera MA

更新日期：1979-05-01 00:00:00

abstract：:Human β-defensin 3 (hBD-3) activates antigen-presenting cells through Toll-like receptors (TLRs) 1/2. Several TLR1/2 agonists have been identified but little is known about how they might differentially affect cellular activation. We compared the effects of hBD-3 with those of another TLR1/2 agonist, Pam(3) CSK(4) , i...

journal_title：Immunology

authors： Funderburg NT,Jadlowsky JK,Lederman MM,Feng Z,Weinberg A,Sieg SF

更新日期：2011-10-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:The output and immunoglobulin class of antibody-containing cells (ACC) in lymph from different regions of adult sheep has been compared following intraperitoneal or subcutaneous injection of ovalbumin in Freund's complete adjuvant (FCA). Intraperitoneal injection of antigen in FCA elicited no response at all in poplit...

journal_title：Immunology

authors： Beh KJ,Lascelles AK

更新日期：1981-04-01 00:00:00

abstract：:Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...

journal_title：Immunology

authors： Rönnberg E,Johnzon CF,Calounova G,Garcia Faroldi G,Grujic M,Hartmann K,Roers A,Guss B,Lundequist A,Pejler G

更新日期：2014-10-01 00:00:00

abstract：:The effector CD8(+) T cells recognize major histocompatibility complex (MHC) class I binding altered self-peptides expressed in tumour cells. Although the requirement for CD4(+) T helper type 1 (Th1) cells in regulating CD8(+) T cells has been documented, their target epitopes and functional impact in antitumour respo...

journal_title：Immunology

authors： Kikuchi T,Uehara S,Ariga H,Tokunaga T,Kariyone A,Tamura T,Takatsu K

更新日期：2006-01-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:Within the lesions of inflammatory myopathies, muscle fibres and invading mononuclear cells express Fas and Fas ligand (FasL), respectively. However, the roles of the Fas/FasL interaction in the pathogenesis of inflammatory myopathies are not fully understood. In the present study, we investigated the roles of proinfl...

journal_title：Immunology

authors： Kondo M,Murakawa Y,Harashima N,Kobayashi S,Yamaguchi S,Harada M

更新日期：2009-09-01 00:00:00

abstract：:This paper uses B-lymphocyte cloning methods to quantify the effects of anti-mu chain antibody on immature and mature B cells. Nude mouse spleen lymphocytes were incubated with various concentrations of sheep anti-mouse mu chain antibody for times varying from 10 min to 24 h. They were then washed and plated in the ag...

journal_title：Immunology

authors： Nossal GJ,Pike BL,Battye FL

更新日期：1979-05-01 00:00:00

abstract：:LacZ (Gal)-reactive immune cells were transferred into athymic nu/nu mice inoculated with Gal-expressing syngeneic tumour cells (ESbL-Gal) in order to study tumour-protective T-cell memory. This transfer prevented tumour outgrowth in recipients and resulted in the persistence of a high frequency of Gal-specific CD8(+)...

journal_title：Immunology

authors： Mahnke YD,Schwendemann J,Beckhove P,Schirrmacher V

更新日期：2005-07-01 00:00:00

abstract：:Suramin, a polyanionic and polycyclic compound, was initially used for the treatment of trypanosomiasis and onchocerciasis. In the last decade, it has been used in therapy of cancer and acquired immune deficiency syndrome (AIDS). The influence of suramin on the expression of various markers by human mononuclear phagoc...

journal_title：Immunology

authors： Schiller C,Spittler A,Willheim M,Szépfalusi Z,Agis H,Köller M,Peterlik M,Boltz-Nitulescu G

更新日期：1994-04-01 00:00:00

abstract：:Factor B-like activity associated with human peripheral blood lymphocytes was first described by Halbwachs & Lachmann (1976), who employed a functional assay. In this present study, clones of B cells from patients with chronic lymphatic leukaemia (CLL) and lymphoblastoid 'Raji' cells were used. The surface of these ce...

journal_title：Immunology

authors： Woo P,Lachmann PJ

更新日期：1981-11-01 00:00:00

abstract：:Radiation chimaeras, prepared from NIH (rapid-responder) mice or from the F1 progeny of a cross between H-2 compatible B10.G (slow-responder) and NIH mice, were tested for their ability to respond to infection with the intestinal nematode parasite Trichinella spiralis. Mice reconstituted with bone marrow (BM) from NIH...

journal_title：Immunology

authors： Wakelin D,Donachie AM

更新日期：1981-08-01 00:00:00

abstract：:Cyclophosphamide was used to assess the role of suppressor cells in the contact sensitivity reaction. A single painting with 300 microgram and 30 microgram oxazolone produced poor contact sensitivity reactions (ear swelling). Cyclophosphamide (200 mg/kg) 2 days before painting increased the response to the lower doses...

journal_title：Immunology

authors： Asherson GL,Perera MA,Thomas WR

更新日期：1979-03-01 00:00:00

abstract：:Degradation of the extracellular matrix plays an important role in rheumatoid articular destruction. Rheumatoid synovial fibroblasts secrete a large amount of matrix-degrading metalloproteinases (MMPs), which initiate tissue damage by proteolytic degradation of collagens and proteoglycans. Cytokines, such as interleuk...

journal_title：Immunology

authors： Migita K,Eguchi K,Kawabe Y,Ichinose Y,Tsukada T,Aoyagi T,Nakamura H,Nagataki S

更新日期：1996-12-01 00:00:00

abstract：:We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the Ly49A receptor. Affinity chromatography using peptides corresponding to the N-terminal 18 amino acids of Ly49A allowed the recovery of a number of proteins that bound preferentially to the ty...

journal_title：Immunology

authors： Daws MR,Eriksson M,Oberg L,Ullén A,Sentman CL

更新日期：1999-08-01 00:00:00

abstract：:Lymphocyte migration into inflammatory sites involves a change from a spherical, non-motile phenotype to an irregular, constantly shape-changing, motile phenotype. We have previously shown that lymphocytes are maintained in the non-motile state by the constitutive activity of protein kinase C (PKC). In this paper we h...

journal_title：Immunology

authors： Thorp KM,Verschueren H,De Baetselier P,Southern C,Matthews N

更新日期：1996-03-01 00:00:00

abstract：:T-cell mediated immunity (CMI) is crucial for protection against genital chlamydial infection in mice. To define the underlying molecular mechanism for this protection, several T-cell clones generated against the Chlamydia trachomatis agent of mouse pneumonitis (MoPn) were analysed in an in vitro model of the mucosal ...

journal_title：Immunology

authors： Igietseme JU

更新日期：1996-01-01 00:00:00

abstract：:Chlamydiae are a major cause of infertility and preventable blindness and there is currently no effective vaccine in humans or rodents against these organisms. We have previously shown that a peptide of 12 amino acids (termed TINKP) from a conserved region of the major outer membrane protein (MOMP) of Chlamydia tracho...

journal_title：Immunology

authors： Knight SC,Iqball S,Woods C,Stagg A,Ward ME,Tuffrey M

更新日期：1995-05-01 00:00:00

abstract：:Rat mast cells with the properties of mucosal mast cells (MMC) proliferate in cultures of haemopoietic tissue in the presence of conditioned medium (CM) from antigen- or mitogen-activated T lymphocytes. The present study shows that recombinant rat interleukin-3 (rIL-3) both stimulated the development of MMC from bone ...

journal_title：Immunology

authors： Haig DM,McMenamin C,Redmond J,Brown D,Young IG,Cohen SD,Hapel AJ

更新日期：1988-10-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytoplasmic CTLA-4 (cCTLA-4)...

journal_title：Immunology

authors： Karabon L,Kosmaczewska A,Bilinska M,Pawlak E,Ciszak L,Jedynak A,Jonkisz A,Noga L,Pokryszko-Dragan A,Koszewicz M,Frydecka I

更新日期：2009-09-01 00:00:00

abstract：:The influence of changes of the cation-transporting activity of the membrane Na,K ATP-ase of human peripheral blood lymphocytes on their ability to form 'early' and 'late' rosettes with SRBC was investigated. It was shown that inhibition of the Na,K ATP-ase-dependent cation transport through the lymphocyte membrane by...

journal_title：Immunology

authors： Witkowski J

更新日期：1985-06-01 00:00:00

abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

journal_title：Immunology

authors： Pedersen AE,Jungersen MB,Pedersen CD

更新日期：2011-06-01 00:00:00

abstract：:Mouse models and a recent vaccine trial have indicated the importance of T-cell immunity to the circumsporozoite protein (CSP) of malaria sporozoites. One of the major impediments for the development of a CSP-based vaccine is that human T-cell epitopes, identified on the CSP, span regions of significant point mutation...

journal_title：Immunology

authors： Zevering Y,Khamboonruang C,Good MF

更新日期：1998-07-01 00:00:00

abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...

journal_title：Immunology

authors： Jiang H,Lint TF,Gewurz H

更新日期：1991-12-01 00:00:00

abstract：:Adoptive transfer of anti-Listeria resistance by Listeria-immune spleen T cells was markedly reduced by pretreatment of the cells with monoclonal anti-Lyt 2.2 and complement (Lyt 2+C); pretreatment of cells with monoclonal anti-L3T4 and complement (L3T4+C) had a lesser effect on their ability to transfer resistance. L...

journal_title：Immunology

authors： Czuprynski CJ,Brown JF

更新日期：1987-02-01 00:00:00