Rat IL-3 stimulates the growth of rat mucosal mast cells in culture.

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:The mouse T-cell tumours E1-4 and WEHI-22 produce an immunoglobulin (TCT Ig) which suppresses the antibody response to T- dependent antigens in vitro while having no effect on responses to T-independent antigens. TCT Ig also augments IgG responses to both kinds of antigen. TCT Ig appears to be a new class of mouse Ig ...

journal_title：Immunology

authors： Boylston AW,Watson SR,Anderson RL

更新日期：1976-11-01 00:00:00

abstract：:Chlamydiae are a major cause of infertility and preventable blindness and there is currently no effective vaccine in humans or rodents against these organisms. We have previously shown that a peptide of 12 amino acids (termed TINKP) from a conserved region of the major outer membrane protein (MOMP) of Chlamydia tracho...

journal_title：Immunology

authors： Knight SC,Iqball S,Woods C,Stagg A,Ward ME,Tuffrey M

更新日期：1995-05-01 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) of infectious bovine rhinotracheitis (IBR)-infected bovine kidney cells (MDBK) by neutrophils was demonstrated. Neutrophils from bovine and sheep mammary exudate and peripheral blood, and also from human peripheral blood, were all active in the presence of anti-IBR ...

journal_title：Immunology

authors： Thorne KJ,Norman JM,Haydock SF,Lammas DA,Duffus PH

更新日期：1984-10-01 00:00:00

abstract：:Mast cell secretory granules contain unique tryptic and chymotryptic serine proteases that differ between species and tissues. Direct comparison of these proteases in single-cell types has been hindered by the difficulty of obtaining adequate numbers of pure mast cells. In this study, we were able to compare tryptic a...

journal_title：Immunology

authors： Caughey GH,Lazarus SC,Viro NF,Gold WM,Nadel JA

更新日期：1988-02-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiation from the DN to DP...

journal_title：Immunology

authors： Wong WF,Nakazato M,Watanabe T,Kohu K,Ogata T,Yoshida N,Sotomaru Y,Ito M,Araki K,Telfer J,Fukumoto M,Suzuki D,Sato T,Hozumi K,Habu S,Satake M

更新日期：2010-06-01 00:00:00

abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

journal_title：Immunology

authors： Sivakumar PV,Foster DC,Clegg CH

更新日期：2004-06-01 00:00:00

abstract：:The numbers of murine hepatocytes and Kupffer cells with receptors for human polymeric (pIgA) or monomeric IgA (mIgA) were determined by rosette formation with immunobeads coated with human pIgA or mIgA. About 63% of hepatocytes were found to express receptors for pIgA. Receptors for mIgA were also found in a signific...

journal_title：Immunology

authors： Sancho J,Gonzalez E,Egido J

更新日期：1986-01-01 00:00:00

abstract：:The isolation and characterization of a new eosinophil-derived protein, eosinophil protein X (EPX) is here described. The purified EPX is a highly basic glycoprotein and shows one band on sodium dodecyl sulphate polyacrylamide gel electrophoresis and on agarose electrophoresis. The molecular weight of the unreduced pr...

journal_title：Immunology

authors： Peterson CG,Venge P

更新日期：1983-09-01 00:00:00

abstract：:Typhoid fever is a persistent infection caused by host-adapted Salmonella strains adept at circumventing immune-mediated host defences. Given the importance of T cells in protection, the culling of activated CD4+ T cells after primary infection has been proposed as a potential immune evasion strategy used by this path...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Mysz MA,Nanton MR,Rowe JH,Aguilera MN,Way SS

更新日期：2011-12-01 00:00:00

abstract：:Murine spleen cells were analysed for their capacity to lyse 51Cr-labelled antibody-sensitized erythrocytes and a human lymphoma cell line. Incubation of spleen cells with iron powder followed by removal of iron-containing cells with a magnet significantly decreased the lytic capacity of the remaining cells against er...

journal_title：Immunology

authors： Lamon EW,Pollok BA,Walia AS,Fuson EW,Williams B

更新日期：1981-08-01 00:00:00

abstract：:Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with diseas...

journal_title：Immunology

authors： Lundqvist S,Modvig S,Fischer EA,Frederiksen JL,Degn M

更新日期：2019-03-01 00:00:00

abstract：:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...

journal_title：Immunology

authors： Kruger M,Coorevits L,De Wit TP,Casteels-Van Daele M,Van De Winkel JG,Ceuppens JL

更新日期：1996-01-01 00:00:00

abstract：:Repetitive stimulation of naïve T cells by immature splenic dendritic cells (DC) can result in the differentiation of T-cell lines with regulatory properties. In the present study we identified a population of DC in the mucosae that exhibit the plasmacytoid phenotype, secrete interferon-alpha (IFN-alpha) following sti...

journal_title：Immunology

authors： Bilsborough J,George TC,Norment A,Viney JL

更新日期：2003-04-01 00:00:00

abstract：:A decrease in the number of dendritic cells (DCs) is a major cause of post-sepsis immunosuppression and opportunistic infection and is closely associated with poor prognosis. Increasing the number of DCs to replenish their numbers post sepsis can improve the condition. This therapeutic approach could improve recovery ...

journal_title：Immunology

authors： Wang HW,Yang W,Gao L,Kang JR,Qin JJ,Liu YP,Lu JY

更新日期：2015-05-01 00:00:00

abstract：:In mice, the plasma cell (PC) niche in the bone marrow is close to the haematopoietic stem cell (HSC) niche. We investigated whether PCs can be mobilized into the peripheral blood (PB) in healthy donors receiving granulocyte colony-stimulating factor (G-CSF) for the induction of HSC mobilization into the PB. G-CSF inc...

journal_title：Immunology

authors： Caraux A,Perez-Andres M,Larroque M,Requirand G,Lu ZY,Kanouni T,Rossi JF,Orfao A,Klein B

更新日期：2011-02-01 00:00:00

abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...

journal_title：Immunology

authors： Magro AM

更新日期：1980-03-01 00:00:00

abstract：:The generation of effective immunity requires that antigen-specific T cells are activated, clonally expanded and ultimately eliminated by apoptosis. The involvement of CD95-mediated apoptosis in T-cell elimination is well established, but the conditions which regulate the death pathway under normal circumstances are s...

journal_title：Immunology

authors： Walker LS,McLeod JD,Boulougouris G,Patel YI,Ellwood CN,Hall ND,Sansom DM

更新日期：1999-12-01 00:00:00

abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...

journal_title：Immunology

authors： Ianaro A,O'Donnell CA,Di Rosa M,Liew FY

更新日期：1994-07-01 00:00:00

abstract：:The effect on murine immunoglobulin G (IgG) glycosylation of altering IgG production in vivo was assessed in interleukin (IL)-6 transgenic and CD4 knockout mice. C57BL/6 mice carrying the IL-6 transgene showed increased levels of circulating IgG. This was associated with decreased levels of galactose on the IgG oligos...

journal_title：Immunology

authors： Jeddi P,Keusch J,Lydyard PM,Bodman-Smith KB,Chesnutt MS,Wofsy D,Hirota H,Taga T,Delves PJ

更新日期：1999-11-01 00:00:00

abstract：:Expression of Fc gamma receptors on human placental trophoblast was investigated by immunostaining and immunoblotting using a panel of Fc gamma receptor monoclonal antibodies (mAb). Fc gamma receptors typical of other cell types were not detected on syncytiotrophoblast in term placentae when transplacental IgG transpo...

journal_title：Immunology

authors： Wainwright SD,Holmes CH

更新日期：1993-11-01 00:00:00

abstract：:Endothelial cell activation antigens may play important roles in immune responses and in inflammation. This report describes the identification and characterization of a monoclonal antibody, named EAA-B, which reacts specifically with human umbilical vein endothelial (HUVE) cells pre-treated with tumour necrosis facto...

journal_title：Immunology

authors： To SS,Magoulas T,Nicholson E,Schrieber L

更新日期：1992-08-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:The biological effects of three thymosin fraction 5 polypeptides, designated as beta 10, beta 4, and alpha 1 were tested in the MLR of mouse splenocytes, lymph node cells and thymocytes against syngeneic or allogeneic stimulators. It was found that all three polypeptides, after in vivo and in vitro treatment of the re...

journal_title：Immunology

authors： Baxevanis CN,Perez S,Kokkinopoulos D,Papamichail M

更新日期：1985-04-01 00:00:00

abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...

journal_title：Immunology

authors： Sminia T,Delemarre F,Janse EM

更新日期：1983-09-01 00:00:00

abstract：:T lymphocytes and macrophages (M phi) have been seen to accumulate at sites of lesions in blood vessel walls, suggesting that these cells may contribute to the pathogenesis of inflammatory reactions. Tumour necrosis factor-alpha (TNF-alpha), a cytokine produced by both M phi and T lymphocytes, plays a major role in in...

journal_title：Immunology

authors： Hershkoviz R,Gilat D,Miron S,Mekori YA,Aderka D,Wallach D,Vlodavsky I,Cohen IR,Lider O

更新日期：1993-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important pattern recognition molecules that activate the nuclear factor (NF)-kappaB pathway leading to the production of antimicrobial immune mediators. As keratinocytes represent the first barrier against exogenous pathogens in human skin, we investigated their complete functional TLR1...

journal_title：Immunology

authors： Köllisch G,Kalali BN,Voelcker V,Wallich R,Behrendt H,Ring J,Bauer S,Jakob T,Mempel M,Ollert M

更新日期：2005-04-01 00:00:00

abstract：:The response of peripheral blood mononuclear cells to pokeweed mitogen (PWM) stimulation was investigated with combined light (LM) and scanning electron microscopy (SEM). The DNA content of the nucleus of a cell (measured by fluorescence) was compared directly with the diameter and morphological features (by SEM). It ...

journal_title：Immunology

authors： Wouters CH,van der Weij JP,Koper GJ,Daems WT,de Vries E,Ploem JS

更新日期：1986-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...

journal_title：Immunology

authors： Fattal I,Shental N,Molad Y,Gabrielli A,Pokroy-Shapira E,Oren S,Livneh A,Langevitz P,Pauzner R,Sarig O,Gafter U,Domany E,Cohen IR

更新日期：2014-02-01 00:00:00