Abstract：
:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further patients had a low C1q and three a low C3 unassociated with any other complement abnormality. No association with any particular IgG subclass or obvious clinical abnormality existed in association with hypocomplementaemia.
journal_name
Immunologyjournal_title
Immunologyauthors
Naish PF,Collins C,Barratt Jsubject
Has Abstractpub_date
1977-10-01 00:00:00pages
517-21issue
4eissn
0019-2805issn
1365-2567journal_volume
33pub_type
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